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Browsing University of Hertfordshire by Author "Hasenoehrl, R."
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The CB1 cannabinoid receptor antagonist AM251 blocks amphetamine-induced behavioural sensitization together with monoamine changes in the mouse nucleus accumbens and hippocampus
Thiemann, G.; Di Marzo, V.; Molleman, A.; Hasenoehrl, R. (2007)Endogenous cannabinoids modulate the activity of dopamine reward pathways and may play a role in the development of behavioural sensitization to psychostimulants. Here, we investigated the effects of the CB1 cannabinoid ... -
Comparison of intra-accumbens injection of histamine with histamine H1-receptor antagonist chlorpheniramine in effects on reinforcement and memory parameters
Hasenoehrl, R.; Kuhlen, A.; Frisch, C.; Brandao, M.L.; Galosi, R.; Huston, J.P. (2001)Histaminergic neurons are located exclusively in the tuberomammillary nuclei (TM) of the hypothalamus from where they project to many regions of the brain including the basal ganglia. Earlier experiments led to the hypothesis ... -
Comparison of neurokinin SP with diazepam in effects on memory and fear parameters in the elevated T-maze free exploration paradigm
Echeverry, M.B.; Hasenoehrl, R.; Huston, J.P.; Tomaz, C. (2001)The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear ... -
Contralateral increase in thigmotactic scanning following unilateral cryogenic barrel-cortex lesion in mice
Luhmann, H.J.; Huston, J.P.; Hasenoehrl, R. (2005)Adult C57BL/6 mice received uni- or bilateral cryogenic or sham-lesions over the barrel field and their exploratory behaviour was assessed in an open field between 1 and 7 days post-lesion. Bilateral cortical lesions ... -
Effects of chronic intraventricular infusion of heparin glycosaminoglycan on learning and brain acetylcholine parameters in aged rats
Jezek, K.; Schulz, D.; De Souza Silva, M.A.; Muller, H.W.; Huston, J.P.; Hasenoehrl, R. (2003)We reported previously that the glycosaminoglycan heparin (HP) has the facility to improve learning in adult rodents when administered into the nucleus basalis of the ventral pallidum. Here we gauged the effects of chronic ... -
Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava)
Thompson, R.; Ruch, W.; Hasenoehrl, R. (2004) -
Enhanced conditioned inhibitory avoidance by a combined extract of zingiber officinale and ginkgo biloba
Topic, B.; Hasenoehrl, R.; Hacker, R.; Huston, J.P. (2002) -
Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat
Topic, B.; Tani, E.; Tsiakitzis, K.; Kourounakis, P.N.; Dere, E.; Hasenoehrl, R.; Hacker, R.; Mattern, C.M.; Huston, J.P. (2002)Here we assessed the effects of i.g. administration of Zingicomb (ZC), a mixture of zingiber officinale and ginkgo biloba extracts, on learning and memory, and on indicators of oxidative stress in aged rats. Effects of ZC ... -
Facilitation of learning and modulation of frontal cortex acetylcholine by ventral pallidal injection of heparin glucosaminoglycan
De Souza Silva, M.A.; Jezek, K.; Weth, K.; Muller, H.W.; Huston, J.P.; Brandao, M.L.; Hasenoehrl, R. (2002)We examined the effects of heparin on learning and frontal cortex acetylcholine parameters following injection of the glucosaminoglycan into the ventral pallidum. In Experiment 1, possible mnemoactive effects of intrapallidal ... -
The genetic versus pharmacological invalidation of the cannabinoid CB1 receptor results in differential effects on non-associative memory and forebrain monoamine concentrations in mice
Thiemann, G.; Fletcher, Ben; Ledent, C.; Molleman, A.; Hasenoehrl, R. (2007) -
Hyperanxiety produced by periaqueductal gray injection of chondroitin sulphate glycosaminoglycan
De Araujo, J.; Hasenoehrl, R.; Huston, J.P.; Brandao, M.L. (2001)We examined the effects of chondroitin sulphate C (CSC) on fear and anxiety parameters following injection of the glycosaminoglycan into the dorsal periaqueductal gray. Rats with chronically implanted cannulae were ... -
Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A and alpha-adrenoceptor binding in hippocampus
Topic, B.; Willuhn, I.; Palomero-Gallagher, N.; Zilles, K.; Huston, J.P.; Hasenoehrl, R. (2007) -
Learning deficits in aged rats related to decrease in extracellular volume and loss of diffusion anisotropy in hippocampus
Syková, E.; Mazel, T.; Hasenoehrl, R.; Harvey, A.R.; Simonová, Z.; Mulders, W.; Huston, J.P. (2002) -
Repeated treatment with cholecystokinin octapeptide improves maze performance in aged Fischer 344 rats
Voits, M.; Hasenoehrl, R.; Huston, J.P.; Fink, H. (2001)Previous studies have shown that sulfated cholecystokinin octapeptide (CCK-8S) can improve learning in adult rodents when administered systemically or into the central nucleus of amygdala. Here we analyzed the effect of ... -
The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization
Thiemann, G.; van der Stelt, M.; Petrosino, S.; Molleman, A.; Di Marzo, V.; Hasenoehrl, R. (2008)Cannabinoid receptors and their endogenous ligands (endocannabinoids) have been implicated in cocaine and amphetamine reward. Their role in psychostimulant-induced behavioural sensitization still has to be determined. The ...