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Browsing University of Hertfordshire by Author "Jones, S. A."
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Biocompatible polymer blends : Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)
Jones, S. A.; Martin, G P; Royall, P.G.; Brown, Marc (2005-12-05)Blending is a very effective method for manufacturing new polymeric materials; however, the process used to combine two polymers can influence the physicochemical properties of the final product. As such, the aim of this ... -
Characterization of latent heat-releasing phase change materials for dermal therapies
Wood, D.G.; Brown, Marc; Jones, S. A.; Murnane, D. (2011-04-28)Phase change materials (PCMs) have been developed as heat storage solutions, particularly for the supply of “green” energy. One interesting use of PCMs is long-term energy storage, in which a phase transition is triggered ... -
Controlling the disposition of gallium complexes in human skin using iontophoresis
Staff, K.; Jones, S. A.; Brown, Marc (2010-06) -
Dermal and transdermal drug delivery systems : Current and future prospects
Brown, Marc; Martin, Gary P.; Jones, S. A.; Akomeah, F. K. (2006)The protective function of human skin imposes physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have adequate lipophilicity and ... -
Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents
Traynor, M.J.; Turner, R. B.; Evans, C.R.G.; Khengar, R. H.; Jones, S. A.; Brown, Marc (2010-06)Objectives The aim of this study was to demonstrate the effect of a novel permeation enhancer system using two existing marketed nail lacquers and the delivery of terbinafine through human nail samples in vitro. Methods ... -
Effect of a novel penetration enhancer system on the ungual permeation of antifungal agents
Griffith, H. M. T.; Traynor, M.J.; Turner, R. B.; Evans, C. R. G.; Khengar, R. H.; Jones, S. A.; Brown, Marc (2010-06) -
The effect of complex coordination on gallium determination using ion chromatography
Staff, K.; Brown, Marc; Jones, S. A.; Friden, P. (2008-09)Interest in the therapeutic use of gallium is increasing due to the discovery of its effectiveness as an anti-tumour and anti-microbial agent (Bernstein 1998). However, gallium strongly coordinates with many organic and ... -
The effect of temperature on the diffusion of lidocaine base
Wood, D. G.; Brown, Marc; Jones, S. A. (2008-09)The inherent barrier properties of the skin present a major problem for the transdermal delivery of drugs. Due to the selectively permeable nature of the skin compounds need to be relatively lipophilic with a molecular ... -
Human Nail Plate Modifications Induced by Onychomycosis : Implications for Topical Therapy
Baraldi, A.; Jones, S. A.; Guesné, S.; Traynor, M.J.; McAuley, W. J.; Brown, Marc; Murdan, S. (2015-05-01)Conclusions: Onchomycotic nails presented a thicker but more porous barrier, and its eroded intracellular matrix rendered the tissue more permeable to topically applied chemicals when an aqueous vehicle was used.Purpose: ... -
In situ self assembly of soft diclofenac loaded microparticles in superstructured fluids
Benaouda, F.; Bachoo, Z.; Brown, Marc; Martin, Gary P; Jones, S. A. (2013-09)This study investigated how the in situ construction and payload delivery from soft diclofenac loaded hydroxypropylmethylcellulose (HPMC) coated microparticles was influenced by the superstructure of the cosolvent in which ... -
An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates
McAuley, W. J.; Jones, S. A.; Traynor, M.J.; Guesné, S.; Murdan, S.; Brown, Marc (2016-05)The treatment of onychomycosis remains problematic even though there are several potent antifungal agents available for patient use. The aim of this investigation was to understand if the structural modifications that arise ... -
Ionised Salbutamol Transport in the Presence of Counterions
Patel, A.; Page, C. P.; Brown, Marc; Jones, S. A. (2010-10) -
Manipulation of beclomethasone-hydrofluoroalkane interactions using biocompatible macromolecules
Jones, S. A.; Martin, G P; Brown, Marc (2006-05)The aim of this work was to physically stabilise beclomethasone dipropionate biocompatible polymers in order to allow the efficient delivery of the steroid to the airways from a pressurised metered dose inhaler (pMDI). BDP ... -
Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers
Khengar, R. H.; Jones, S. A.; Turner, R. B.; Forbes, B.; Brown, Marc (2007-12)Introduction. Targeting drug treatment to fungal infections that reside within or below the nail plate is problematic due to the highly restrictive barrier of the human nail. To optimise topical formulations for ungual ... -
Novel strategy for enhancing transdermal drug delivery
Wood, D. G.; Brown, Marc; Jones, S. A. (2010-06) -
Overcoming the nail barrier : A systematic investigation of ungual chemical penetration enhancement
Brown, Marc; Khengar, Rajeshree H.; Turner, Rob B.; Forbes, B.; Traynor, M.J.; Evans, C.R.G.; Jones, S. A. (2009-03-31)This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration ... -
Pharmaceutical foams : are they the answer to the dilemma of topical nanoparticles?
Zhao, Y.; Brown, Marc; Jones, S. A. (2010)Nanoparticulate systems have the potential to improve topical drug delivery because of their capacity to enhance drug loading and dissolution, protect chemically unstable therapeutic agents, and improve product aesthetics. ... -
Recovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatography
Staff, K.; Brown, Marc; Hider, R. C.; Kong, X. L.; Friden, P.; Jones, S. A. (2010-09)Ion exchange chelation chromatography is an effective means to extract metals from coordination complexes and biological samples; however there is a lack of data to verify the nature of metal complexes that can be successfully ... -
The topical delivery of benzoyl peroxide using elegant dynamic hydrofluoroalkane foams
Zhao, Y.; Brown, Marc; Jones, S. A. (2010)Formulating benzoyl peroxide (BPO) in an effective topical product is challenging due to its poor water solubility and chemical instability, but delivering BPO using elegant foams is an attractive solution to this problem. ... -
Transiently supersaturated solutions from the dissolution of amorphous powders for topical drug delivery
Palmer, I. A.; Jones, S. A.; Murnane, D.; Traynor, M.J.; Moss, Gary; Brown, Marc (2010-06)The aim of this study was to prepare amorphous forms of clotrimazole to determine whether increasing the rate and extent of dissolution of clotrimazole would result in supersaturated solutions capable of increasing the ...