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Browsing University of Hertfordshire by Author "Kukol, Andreas"
Now showing items 1-13 of 13
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Combination of Ipsative and Sociomaterial Assessment Methodologies within University-Level Science Education
Kukol, Andreas (2024-09-05)This article presents a comprehensive exploration of ipsative and sociomaterial assessment methodologies, dissecting their theoretical frameworks, practical implementations, and the resultant effects on educational paradigms. ... -
Comparative modelling of the kinase IKK-beta and prediction of inhibitors
Kalia, Munishikha; Varsani, Poonam; Kukol, Andreas (2019-10-08) -
Development of lux-based biosensors in P. aeruginosa ATCC 9027 for preservative efficacy testing
Shah, Niksha; Kukol, Andreas; Naseby, David (2012) -
Evaluation of a novel virtual screening strategy using receptor decoy binding sites
Patel, Hershna; Kukol, Andreas (2016-08-23)Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets. This report shows the development and evaluation of a novel yet ... -
Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors
Patel, Hershna; Kukol, Andreas (2017-09-01)The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions ... -
Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae
Stotz, Henrik; Pascoe, Harvey; Parham, Haddadi; Fitt, Bruce; Mashanova, Alla; Kukol, Andreas; Larkan, Nicholas; Hossein, Borhan (2018-06-01)Genes coding for nucleotide-binding leucine-rich repeat (LRR) receptors (NLRs) control resistance against intracellular (cell-penetrating) pathogens. However, evidence for a role of genes coding for proteins with LRR domains ... -
Integrating molecular modelling methods to advance influenza A virus drug discovery
Patel, Hershna; Kukol, Andreas (2020-11-19)Since the discovery of the anti-influenza drugs Oseltamivir and Zanamivir using computer aided drug design methods, there have been significant applications of molecular modelling methodologies applied to influenza A virus ... -
L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes
Himes, Ryan D.; Smolin, Nikolai; Kukol, Andreas; Bossuyit, Julie; Beers, Donald M.; Robia, Seth L. (2016-11-08)To determine if mutations introduced into phospholemman (PLM) could increase the level of PLM–Na,K-ATPase (NKA) binding, we performed scanning mutagenesis of the transmembrane domain of PLM and measured Förster resonance ... -
MicroRNA-Dependent Mechanisms Underlying the Function of a β-Amino Carbonyl Compound in Glioblastoma Cells
Mustafov, Denis; Siddiqui, Shoib; Kukol, Andreas; Lambrou, George; Waseem, Shagufta; Ahmad, Irshad; Braoudaki, Maria (2024-07-23)Glioblastoma (GB) is an aggressive brain malignancy characterized by its invasive nature. Current treatment has limited effectiveness, resulting in poor patients’ prognoses. β-Amino carbonyl (β-AC) compounds have gained ... -
Molecular modeling of influenza A virus proteins
Patel, Hershna; Rapley, Ralph; Kukol, Andreas (2015-12-08) -
Prediction of ligands to universally conserved binding sites of the influenza A virus nuclear export protein
Patel, Hershna; Kukol, Andreas (2019-11-01)The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein sequences and molecular ... -
Recent discoveries of influenza A drug target sites to combat virus replication
Patel, Hershna; Kukol, Andreas (2016-06-09)Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential ... -
Regulation of the Cardiac Na+/K+ ATPase by Phospholemman
Dhayan, Hansraj; Kumar, Rajender; Kukol, Andreas (Springer Nature, 2016)