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Browsing University of Hertfordshire by Author "Li, Chan"
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Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin A2
Li, Chan; Reddy, Tummala Rama Krishna; Fischer, Peter M.; Dekker, Lodewijk V. (2010)Protein–protein interactions are increasingly of interest as targets in small-molecule drug discovery. The interaction between the Ca2+- and phospholipid-binding protein Annexin A2 and its binding partner S100A10 has been ... -
Design, Synthesis and SAR Exploration of Tri-substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction
Reddy, Tummala Rama Krishna; Li, Chan; Guo, Xiaoxia; Fischer, Peter; Dekker, Lodewijk (2014-10-01)Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain ... -
Patent: Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for the treatment of cancer and other diseases
Department of Pharmacy; School of Life and Medical Sciences; Health & Human Sciences Research Institute; Medicinal and Analytical Chemistry; Reddy, Tummala Rama Krishna; Li, Chan; Fischer, Peter M.; Dekker, Lodewijk V. (2011-08-04)This invention relates to compounds that are inhibitors of S100 protein binding interactions, such as, for example, the annexin A2-S100A10 protein binding interaction. More specifically, this invention concerns certain ... -
Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction : Potential anti-angiogenesis therapeutics
Reddy, Tummala Rama Krishna; Li, Chan; Guo, Xiaoxia; Fischer, Peter; Dekker, Lodewijk (2010)