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Browsing University of Hertfordshire by Author "Meadows, H.J."
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Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1
Hayes, P.; Meadows, H.J.; Gunthorpe, M.J.; Harries, M.; Duckworth, M.; Cairns, W.; Harrison, D. C.; Ellington, K.; Prinjha, R.; Barton, A.; Medhurst, A.D.; Smith, G.D.; Topp, S.; Sanger, G.; Jenkins, O.; Benham, C.D.; Gloger, I.; Clarke, C. E.; Murdock, P.; Terrett, J.; Randall, A. D.; Gloger, I. S.; Davis, J. B. (2000-11-01)Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we ... -
Cloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channel
Meadows, H.J.; Benham, C.D.; Cairns, W.; Gloger, I.; Jennings, C.; Medhurst, A.D.; Murdock, P.; Chapman, C.G. (2000)We have cloned human TREK-1, one of the newly emerging mammalian family of 2-P domain potassium channels. The channel has 411 amino acids with a 41-amino-acid extension at the C-terminus when compared with the cloned mouse ... -
Mutation of Histidine 286 of the human P2X4 receptor leads to loss of pH sensitivity
Clarke, C.; Benham, C.D.; Bridges, A.; Sanger, G.; George, A. R.; Meadows, H.J. (2000) -
SB 205384 slows the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum
Meadows, H.J.; Harries, M.; Thompson, M.; Benham, C.D. (1997)4-Amino-7-hydroxy-2-methyl-5,6,7,8,-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid, but-2-ynyl ester (SB-205384) and other γ-aminobutyric acidA (GABAA) receptor modulators were tested for their effects on ... -
SB 205384: A GABA-A receptor modulator with novel mechanism of action that shows subunit selectivity
Meadows, H.J.; Blackburn, T.B.; Pritchett, D.; Benham, C.D. (1998)