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Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis
(2020-04-15)
Poloxamer 407 (polox407) is widely studied as thermogelling polymer, transitioning to a gel state when warmed Polox407 forms weak hydrogels with rapid dissolution in excess solvent. This study reports the development of ...
Is non-chlamydial non-gonococcal urethritis associated with significant clinical complications in men? A systematic review
(2020-03-20)
Background: It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by Chlamydia trachomatis. Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, ...
Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro.
(2020-03-13)
Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies. There is limited understanding if this response ...
Priming Older Adults and People with Mild to Moderate Alzheimer’s Disease Problem-solving with False Memories
(2020-02-04)
In two experiments we investigated whether older adult controls (OACs) and people with mild and moderate Alzheimer’s disease (AD) benefit from false memory priming effects in subsequent problem-solving tasks. In addition, ...
The permeability of human eyelid skin to topically applied lidocaine
(2020-02-01)
This work investigated the permeability of lidocaine across human eyelid skin and compared this with published data for abdominal skin to understand the characteristics of this type of skin and whether topical anaesthesia ...
Do automated digital health behaviour change interventions have a positive effect on self-efficacy? A systematic review and meta-analysis
(2020-01-20)
Self-efficacy is an important determinant of health behaviour. Digital interventions are a potentially acceptable and cost-effective way of delivering programmes of health behaviour change at scale. Whether behaviour change ...
Fathers’ experiences of caring for an adult child with psychosis: A qualitative study
(2020-01-20)
Previous research exploring parental experiences of caring has highlighted both the rewarding nature and associated difficulties with this role. Within these studies the majority of parents have been mothers, resulting in ...
ICTV Virus Taxonomy Profile: Chrysoviridae
(2020-01-20)
Members of the family Chrysoviridae are isometric, non-enveloped viruses with segmented, linear, dsRNA genomes. There are 3–7 genomic segments, each of which is individually encapsidated. Chrysoviruses infect fungi, plants ...
'New/Designer Benzodiazepines': an analysis of the literature and psychonauts’ trip reports
(2020-01-10)
Background: NPS belonging to the benzodiazepine (BZD) class, e.g., ‘legal/designer BZDs’/‘research chemicals’, have recently emerged on the drug (mainly online/virtual) market. Objective: Whilst certain NPS belonging to ...
'New/Designer Benzodiazepines': an analysis of the literature and psychonauts’ trip reports
(2020-01-10)
Background: NPS belonging to the benzodiazepine (BZD) class, e.g., ‘legal/designer BZDs’/‘research chemicals’, have recently emerged on the drug (mainly online/virtual) market. Objective: Whilst certain NPS belonging to ...