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Cerebellar output controls generalized spike-and-wave discharge occurence
(2015-06-01)
Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation ...
Dendritic Morphology Predicts Pattern Recognition Performance in Multi-compartmental Model Neurons with and without Active Conductances
(2015-04-01)
In this paper we examine how a neuron’s dendritic morphology can affect its pattern recognition performance. We use two different algorithms to systematically explore the space of dendritic morphologies: an algorithm that ...
Combining machine learning and simulations of a morphologically realistic model to study modulation of neuronal activity in cerebellar nuclei
(2014-07-21)
Epileptic absence seizures are characterized by synchronized oscillatory activity in the cerebral cortex that can be recorded as so-called spike-and-wave discharges (SWDs) by electroencephalogram. Although the cerebral ...
Information theoretical analysis of differences in information transmission in cerebellar Purkinje cells across species
(2014-07)
The dendrite of the cerebellar Purkinje cell is one of the most complex structures in the mammalian brain, receiving more than 150,000 synaptic inputs. It is also one of the most extensively modelled neurons in the mammalian ...
Evolving spiking neural networks for temporal pattern recognition in the presence of noise
(MIT Press, 2014)
Nervous systems of biological organisms use temporal patterns of spikes to encode sensory input, but the mechanisms that underlie the recognition of such patterns are unclear. In the present work, we explore how networks ...
Synaptic plasticity and pattern recognition in cerebellar Purkinje cells
(Springer Nature, 2014)
Many theories of cerebellar learning assume that long-term depression (LTD) of synapses between parallel fibres (PFs) and Purkinje cells is the basis for pattern recognition in the cerebellum. Here we describe a series of ...