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Self management interventions for type 2 diabetes in adult people with severe mental illness
(2016-04-27)
BACKGROUND: People with severe mental illness are twice as likely to develop type 2 diabetes as those without severe mental illness. Treatment guidelines for type 2 diabetes recommend that structured education should be ...
UK Renal Registry 18th Annual Report : Chapter 12 Epidemiology of Reported Infections amongst Patients Receiving Dialysis for Established Renal Failure in England 2013 to 2014: a Joint Report from Public Health England and the UK Renal Registry
(2016-04-19)
From 1st May 2013 to 30th April 2014 there were 35 episodes of Methicillin resistant Staphylococcus aureus (MRSA) bacteraemia in established renal failure patients on dialysis. This is now fairly stable year-on-year equating ...
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections
(2016-03-21)
Antibiotic-associated diarrhea (AAD) and Clostridium difficile infections (CDI) have been well studied for adult cases, but not as well in the pediatric population. Whether the disease process or response to treatments ...
Quality of Life and Physical Function in Older Patients on Dialysis : A Comparison of Assisted Peritoneal Dialysis with Hemodialysis
(2016-03-07)
BACKGROUND AND OBJECTIVES: In-center hemodialysis (HD) is often the default dialysis modality for older patients. Few centers use assisted peritoneal dialysis (PD), which enables treatment at home. This observational study ...
Comparison of energy estimates in chronic kidney disease using doubly-labelled water
(2016-01-27)
BACKGROUND: Total energy expenditure (TEE) is estimated in clinical practice as a combined measure of resting energy expenditure and physical activity level. Commonly available questionnaires to estimate physical activity ...
The role of natriuretic peptides in volume assessment and mortality prediction in Haemodialysis patients
(2015-12-29)
BACKGROUND: Maintaining optimal fluid balance is essential in haemodialysis (HD) patients but clinical evaluation remains problematic. Other technologies such as bioimpedance are emerging as valuable adjuncts. This study ...
Patterns of disease progression in type 2 and 3 SMA : Implications for clinical trials
(2015-12-03)
The aim of the study was to establish 12-month changes in the Hammersmith Functional motor scale in a large cohort of SMA patients, to identify patterns of disease progression and the effect of different variables. 268 ...
Plasma Levels of Middle Molecules to Estimate Residual Kidney Function in Haemodialysis without Urine Collection
(2015-12-02)
BACKGROUND: Residual Kidney Function (RKF) is associated with survival benefits in haemodialysis (HD) but is difficult to measure without urine collection. Middle molecules such as Cystatin C and β2-microglobulin accumulate ...
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
(2015-12-01)
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...
Selective reporting of results in guidelines
(2015-12)
Taylor and Perera argue persuasively that the 2014 National Institute for Health and Care Excellence (NICE) schizophrenia guideline promotes cognitive–behavioural therapy (CBT) and other psychosocial interventions beyond ...