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Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists
(2001-08-20)
The preparation and biological evaluation of a series of indolopiperidine CCR2B receptor antagonists possessing a conformationally restricted C-5 linker chain in combination with a restricted piperidine ring are described. ...
Sex inequalities in ischaemic heart disease in primary care - Inhouse clinics may help better to manage patients with heart disease
(2001-08-18)
We read Hippisley-Cox's study showing sex inequalities in secondary prevention of ischaemic heart disease in general practice.1 We have just completed an audit of 167 of our patients with ischaemic heart disease (practice ...
Chronobiological variations of indomethacin pharmacokinetic parameters in sheep
(2001-08)
A two-phase study to investigate the influence of administration time on pharmacokinetics of indomethacin in sheep was performed. In phase I, 12 animals were allocated to four groups, each corresponding to a different time: ...
Fructosamine concentration and resistance to natural, predominantly Teladorsagia circumcincta infection
(2001-08)
Fructosamine con cent rations reflect protein status and because infection with Teladorsagia circumcineta can induce a relative protein deficiency, we examined the usefulness of fructosamine concentrations as markers of ...
Dopamine induces hyperpolarization of locust salivary gland acinar cells via D1-like receptors.
(2001-07)
The effect of dopamine on the salivary gland acinar cells of the locust was examined using conventional intracellular recording techniques. Application of dopamine induced a reversible, dose-dependent hyperpolarization of ...
Evidence for a Supermassive Black Hole in the S0 Galaxy NGC 3245
(2001-07-01)
The S0 galaxy NGC 3245 contains a circumnuclear disk of ionized gas and dust with a radius of 1.1" (110 pc), making it an ideal target for dynamical studies with the Hubble Space Telescope (HST). We have obtained spectra ...
Two New Planets from the Anglo-Australian Planet Search
(2001-07)
Precise Doppler measurements from the Anglo-Australian Telescope (AAT) UCLES spectrometer reveal periodic Keplerian velocity variations in the stars HD 160691 and HD 27442. HD 160691 has a period of 743 days, a semiamplitude ...