Browsing Research publications by Author "Extracellular Vesicle Research Unit"

Now showing items 61-80 of 151

    • Impact of frozen section on long-term outcomes in robotic-assisted laparoscopic prostatectomy  

      Kinnear, Ned; Cotter Fonseca, Paul; Ogbechie, Catherine; Adam, Sana; Haidar, Omar; Jinaraj, Aromal; O’Callaghan, Michael; Agarwal, Samita; Lane, Timothy; Vasdev, Nikhil; Adshead, James (2024-07-03)
      Objectives: To compare 1‐year functional and 5‐year oncological outcomes of men undergoing robot‐assisted laparoscopic prostatectomy (RALP) with neurovascular structure‐adjacent frozen‐section examination (NeuroSAFE) with ...

    • Impact of Maximal Transurethral Resection on Pathological Outcomes at Cystectomy in a Large, Multi-institutional Cohort 

      Kirk, Peter S.; Lotan, Yair; Zargar, Homayoun; Zargar, Kamran; Fairey, Adrian S; Dinney, Colin P; Mir, Maria C; Krabbe, Laura-Maria; Cookson, Michael S; Jacobson, Niels-Erik; Montgomery, Jeffrey S; Vasdev, Nikhil; Yu, Evan Y; Xylinas, Evanguelos; Kassouf, Wassim; Dall'Era, Marc A; Sridhar, Srikala S.; McGrath, Jonathan S; Aning, Jonathan; Shariat, Shahrokh F; Thorpe, Andrew C.; Morgan, Todd M; Holzbeierlein, Jeff M; Bivalacqua, Trinity J; North, Scott; Barocas, Daniel A; Grivas, Petros; Garcia, Jorge A; Stephenson, Andrew J; Shah, Jay B; Daneshmand, Siamek; Spiess, Philippe E; van Rhijn, Bas WG; Black, Peter C.; Wright, Jonathan L. (2023-05-01)
      Purpose: While the presence of residual disease at the time of radical cystectomy for bladder cancer is an established prognostic indicator, controversy remains regarding the importance of maximal transurethral resection ...

    • Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer 

      D'Andrea, David; Black, Peter C.; Zargar, Homayoun; Zargar-Shoshtari, Kamran; Zehetmayer, Sonja; Fairey, Adrian S.; Mertens, Laura S.; Dinney, Colin P.; Mir, Maria C.; Krabbe, Laura Maria; Cookson, Michael S.; Jacobsen, Niels Erik; Montgomery, Jeffrey S.; Vasdev, Nikhil; Yu, Evan Y.; Xylinas, Evanguelos; Campain, Nicholas J.; Kassouf, Wassim; Dall'Era, Marc A.; Seah, Jo An; Ercole, Cesar E.; Horenblas, Simon; Sridhar, Srikala S.; McGrath, John S.; Aning, Jonathan; Wright, Jonathan L.; Thorpe, Andrew C.; Morgan, Todd M.; Holzbeierlein, Jeffrey M.; Bivalacqua, Trinity J.; North, Scott; Barocas, Daniel A.; Lotan, Yair; Grivas, Petros; Stephenson, Andrew J.; Shah, Jay B.; van Rhijn, Bas W.; Daneshmand, Siamak; Spiess, Philippe E.; Shariat, Shahrokh F. (2020-02-11)
      Objective: To assess the effect of patient's sex on response to neoadjuvant chemotherapy (NAC) in patients with clinically nonmetastatic muscle-invasive bladder cancer (MIBC). Methods: Complete pathologic response, defined ...

    • The increasing indications of FDG-PET/CT in the staging and management of Invasive Bladder Cancer 

      Omorphos, Nicolas Pavlos; Ghose, Aruni; Hayes, John; Kandala, Abhinav; Dasgupta, Prokar; Sharma, Anand; Vasdev, Nikhil (2022-10-30)
      The management of locally advanced muscle invasive bladder cancer (MIBC) often necessitates neo-adjuvant chemotherapy (NAC) to eliminate any micro-metastatic disease prior to definitive radical cystectomy (RC) and pelvic ...

    • Increasing pumping efficiency in a micro throttle pump by enhancing displacement amplification in an elastomeric substrate 

      Fujiwara, T.; Johnston, I.D.; Tracey, M.C.; Tan, C.K.L (2010)
      Fluid transport is accomplished in a micro throttle pump (MTP) by alternating deformation of a micro channel cast into a polydimethylsiloxane (PDMS) elastomeric substrate. The active deformation is achieved using a bimorph ...

    • An induced population of Trypanosoma cruzi epimastigotes more resistant to complement lysis promotes a phenotype with greater differentiation, invasiveness, and release of extracellular vesicles 

      Rossi , Izadora Volpato; Nunes, Maria Alice Ferreira; Sabatke, Bruna; Ribas , Hennrique Taborda; Winnischofer , Sheila Maria Brochado; Ramos, Augusto Savio Peixoto; Ramirez, Marcel Ivan; Inal, Jameel (2022-12-14)
      Introduction: Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi, which uses blood-feeding triatomine bugs as a vector to finally infect mammalian hosts. Upon entering the host, the parasite needs ...

    • Influence of Elevated Temperatures on Resistance Against Phoma Stem Canker in Oilseed Rape 

      Noel, Katherine; Qi, Aiming; Gajula, Lakshmi; Huang, Yongju; Fitt, Bruce; Stotz, Henrik (2022-03-02)
      Cultivar resistance is an important tool in controlling pathogen-related diseases in agricultural crops. As temperatures increase due to global warming, temperatureresilient disease resistance will play an important role ...

    • Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion 

      Vergari, Elisa; Knudsen, Jakob G; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J B; Chibalina, Margarita V; Gribble, Fiona M; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J G; Spiliotis, Ioannis I; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M; Rorsman, Patrik (2019-01-11)
      Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels ...

    • Interactions in the Brassica napus-Pyrenopeziza brassicae pathosystem and sources of resistance to P. brassicae (light leaf spot) 

      Karandeni Dewage, Chinthani Shanika; Qi, Aiming; Stotz, Henrik U.; Huang, Yongju; Fitt, Bruce D. L. (2021-08-24)
      Pyrenopeziza brassicae, cause of light leaf spot (LLS), is an important pathogen of oilseed rape and vegetable brassicas and has a wide geographic distribution. Exploitation of host resistance remains the most sustainable ...

    • Intravesical Chemohyperthermia vs. Bacillus Calmette-Guerin Instillation for Intermediate- and High-Risk Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis 

      Zhao, Hongda; Chan, Vinson Wai-Shun; Castellani, Daniele; Chan, Erica On-Ting; Ong, William Lay Keat; Peng, Qiang; Moschini, Marco; Krajewski, Wojciech; Pradere, Benjamin; Ng, Chi-Fai; Enikeev, Dmitry; Vasdev, Nikhil; Ekin, Gokhan; Sousa, Alejandro; Leon, Juan; Guerrero-Ramos, Felix; Tan, Wei-Shen; Kelly, John; Shariat, Shahrokh F.; Witjes, J. Alfred; Teoh, Jeremy Yuen-Chun (2021-11-23)
      Background: The efficacy of intravesical chemotherapy maintenance for patients with non-muscle invasive bladder cancer (NMIBC) is inferior compared to intravesical bacillus Calmette–Guerin (BCG). How intravesical ...

    • Is the digital rectal exam any good as a prostate cancer screening test? 

      Kirby, Mike; Merriel, Sam; Olajide, Oluwabunmi; Norman, Alexander; Vasdev, Nikhil; Hanchanale, Vishwanath; Cain, Michelle; Wilkinson, Malcom; Stephens, Harley; Victor, Debbie; Kinnaird, William; Tree, Alison; Challapalli, Amarnath; Rylance, Amy (2024-02-29)
      There is no shortage of references in popular culture to the prostate examination, with many a laugh built on the punchline of the finger up the bum. Interestingly, while cervical, breast, or bowel screening share barriers ...

    • Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy 

      De Sousa, Karina P.; Rossi, Izadora; Abdullahi, Mahamed; Ramirez, Marcel Ivan; Stratton, Dan; Inal, Jameel Malhador (2023-01-13)
      Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer nanoparticles secreted by most cells. EVs are regarded as important mediators of intercellular communication in both prokaryotic and ...

    • A laboratory-based evaluation of tube blocking and microbial risks associated with one blended enteral feed recipe 

      Madden, Angela; Baines, Simon; Bothwell, Simone; Chen, Elise; Goh, Shan; Jerome, Lee; Sommariva-Nagle, Cara; Szychta, Malgorzata (2019-10-01)
      Background: Concerns associated with blended enteral feeds include the risk of blocked tubes and microbial contamination, although the available evidence is limited. The present laboratory-based investigation aimed to ...

    • Leptosphaeria maculans isolates with variations in AvrLm1 and AvrLm4 effector genes induce differences in defence responses but not in resistance phenotypes in cultivars carrying the Rlm7 gene 

      Stotz, Henrik Uwe; Ali, Ajisa Muthayil; de Lope, Lucia Robado; Rafi, Mohammed Sajid; Mitrousia, Georgia Konstantinou; Huang, Yong‐Ju; Fitt, Bruce David Ledger (2023-03-28)
      BACKGROUND The phoma stem canker pathogen Leptosphaeria maculans is one of the most widespread and devastating pathogens of oilseed rape (Brassica napus) in the world. Pathogen colonization is stopped by an interaction of ...

    • Major urological cancer surgery for patients is safe and surgical training should be encouraged during the COVID-19 pandemic : A multi-centre analysis of 30-day outcomes 

      Tan, Wei Shen; Arianayagam, Ranjan; Khetrapal, Pramit; Rowe, Edward; Kearley, Samantha; Mahrous, Ahmed; Pal, Raj; Fowler, William; Heer, Rakesh; Elajnaf, Mohamed; Douglas-Moore, Jayne; Griffiths, TR Leyshon; Voss, James; Wilby, Daniel; Al Kadhi, Omar; Noel, Jonathan; Vasdev, Nikhil; McKay, Alastair; Ahmad, Imran; Abu-Nayla, Islam; Lamb, Benjamin; Hill, George T; Narahari, Krishna; Kynaston, Howard; Yousuf, Arzu; Kusuma, Venkata RM; Cresswell, Joanne; Cooke, Pete; Chakravarti, Aniruddha; Barod, Ravi; Bex, Axel; Kelly, John D (2021-03)
      COVID-19 has resulted in the deferral of major surgery for genitourinary (GU) cancers with the exception of cancers with a high risk of progression. We report outcomes for major GU cancer operations, namely radical ...

    • The Management of Symptomatic Hydronephrosis in Pregnancy 

      Hosny, Mohannad; Chan, Kimberley; Ibrahim, Mohamed; Sharma, Vishali; Vasdev, Nikhil (2024-01-11)
      The aim of this article is to provide a literature review on the management of symptomatic physiological hydronephrosis in pregnancy and compare different modalities of intervention when needed. In this review, we conducted ...

    • Management of Urolithiasis in Pregnancy 

      Chan, Kimberley; El-Taji, Omar; Patel, Amit; Bycroft, John; Lim, Chou Phay; Vasdev, Nikhil (2023-03-01)
      Urolithiasis is the most common cause of nonobstetric abdominal pain, resulting in 1.7 admissions per 1000 deliveries. Urolithiasis most commonly occurs in the second and third trimesters, with an incidence between 1:125 ...

    • Mapping of quantitative trait loci for agronomic and morpho-physiological traits under drought environments in spring barley (Hordeum vulgare L.) 

      Sayed, Haitham; Al-Yassin, Adnan; Ceccarelli, Salvatore; Grando, Stefania; Stotz, Henrik; Fitt, Bruce; Baum, Michael (2024-06-03)
      Barley production is severely affected by drought caused by the unpredictable Mediterranean weather patterns, which include uneven rainfall and extreme temperatures. This leads to a decrease in crop yield. However, to ...

    • Membrane vesicles of Clostridioides difficile and other Clostridial species 

      Goh, Shan; Inal, Jameel (Springer Nature, 2024-01-05)
      Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. Membrane vesicles ...

    • Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury 

      Sisa, Claudia; Kholia, Sharad; Naylor, Jordan; Herrera Sanchez, Maria Beatriz; Bruno, Stefania; Deregibus, Maria Chaiara; Camussi, Giovanni; Inal, Jameel; Lange, Sigrun; Hristova, Mariya (2019-03-19)
      Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need ...