Browsing Research publications by Author "Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit"
Now showing items 61-80 of 319
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Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ... -
Designer Benzodiazepines’ Activity on Opioid Receptors: A Docking Study
Catalani, Valeria; Botha, Michelle; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Schifano, Fabrizio (2022-09-22)BACKGROUND: Previous studies have reported that benzodiazepines (BZDs) seem to enhance euphoric and reinforcing properties of opioids in opioid users so that a direct effect on opioid receptors has been postulated, together ... -
Detection of Newly Emerging Psychoactive Substances Using Raman Spectroscopy and Chemometrics
Calvo-Castro, Jesus; Guirguis, Amira; Samaras, Eleftherios; Zloh, Mire; Kirton, Stewart; Stair, Jacqueline (2018-09-12)A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA) employing the largest dataset of NPS reference materials to date ... -
Detection of nitroaromatic vapours with diketopyrrolopyrrole thin films exploring the role of structural order and morphology on thin film properties and fluorescence quenching efficiency
Warzecha, Monika; Calvo-Castro, Jesus; Kennedy, Alan R.; Macpherson, Alisdair N.; Shankland, Kenneth; Shankland, Norman; McLean, Andrew J.; McHugh, Callum J. (2015-01-21)Sensitive optical detection of nitroaromatic vapours with diketopyrrolopyrrole thin films is reported for the first time and the impact of thin film crystal structure and morphology on fluorescence quenching behaviour demonstrated -
Determination of Cu2+ ions release rate from antimicrobial copper bearing stainless steel by joint analysis using ICP-OES and XPS
Ren, Ling; Chong, J.; Loya, Adil; Kang, Q.; Stair, Jacqueline; Nan, L.; Ren, Guogang (2015-08-30)Antibacterial Cu bearing stainless steels (CuSS) have been developed recently and their performance has attracted significant attention widely in biomedical, healthcare and environmental facilities in cross-disciplines. ... -
Dipendenze farmacologiche e comportamentali
Schifano, Fabrizio (Piccin Nuova Libraria, 2021-11-22) -
Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis
Hartzoulakis, B.; Rossiter, S.; Gill, H.; Steinke, E.; Gane, P.J.; Hurtado-Guerrero, R.; Leiper, J.M.; Vallance, P.; Murray-Rust, J.; Selwood, D.L. (2007) -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ... -
Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ... -
Dissociative experiences of compartmentalization are associated with food addiction symptoms: results from a cross‐sectional report
Carbone, Giuseppe Alessio; De Rossi, Elena; Prevete, Elisabeth; Tarsitani, Lorenzo; Corazza, Ornella; Massullo, Chiara; Farina, Benedetto; Pasquini, Massimo; Taddei, Ines; Biondi, Massimo; Imperatori, Claudio; Bersani, Francesco Saverio (2023-03-03)Purpose: Studies have shown significant associations of dissociative symptoms with both eating and addictive disorders; however, the different forms of dissociation have been relatively understudied in relation to food ... -
Dorsal Prefrontal Cortex Impairment in Methoxetamine-Induced Psychosis: an 18F-FDG PET/CT Case Study
Moccia, Lorenzo; Tofani, Anna; Mazza, Marianna; Covino, Marcello; Martinotti, Giovanni; Schifano, Fabrizio; Janiri, Luigi; Di Nicola, Marco (2019-05-27)Novel psychoactive substances (NPSs) have currently become a major public health concern because of relatively easy accessibility to these compounds and difficulty in identifying them with routine laboratory techniques. ... -
Drowning in Diversity? A systematic way of clustering a representative set of new psychoactive substances
Zloh, Mire; Samaras, Eleftherios; Calvo-Castro, Jesus; Guirguis, Amira; Stair, Jacqueline; Kirton, Stewart (2017-11-17)New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs, but are not subject to restriction or control with respect to ... -
The Dynamic Environment of Crypto Markets: The Lifespan of New Psychoactive Substances (NPS) and Vendors Selling NPS
Schifano, Fabrizio (2020-03-16)The Internet has played a major role in the distribution of New Psychoactive Substances (NPS), and crypto markets are increasingly used for the anonymous sale of drugs, including NPS. This study explores the availability ... -
The e-psychonaut drugs’ psychopharmacology
Schifano, Fabrizio; Chiappini, Stephania; Corkery, John Martin; Scherbaum, Norbert; Guirguis, Amira (2021-04-01)The focus here was on the pharmacological and clinical pharmacological issues pertaining to the vast range of drugs (e.g. synthetic cannabimimetics, synthetic opioids, novel stimulants, novel psychedelics, PCP/ketamine-like ... -
The e-psychonauts’ ‘Spiced’ World; assessment of the synthetic cannabinoids’ information available online
Zangani, Caroline; Schifano, Fabrizio; Napoletano, Flavia; Arillotta, Davide; Gilgar, Liam; Guirguis, Amira; Corkery, John Martin; Gambini, Orsola; Vento, Alessandro (2020-03-02)Background: A wide range of novel psychoactive substances (NPS) is regularly searched and discussed online by web-based drug enthusiasts (i.e. the e-psychonauts). Among NPS, the range of synthetic cannabinoids (SC; ‘Spice’) ... -
Editorial: Misuse and abuse of prescription drugs in custodial settings
Perani, Filippo; Chiappini, Stefania; Schifano, Fabrizio; Giorgetti, Arianna (2023-11-30) -
Editorial: Prescribing Psychotropics: Misuse, Abuse, Dependence, Withdrawal and Addiction
Chiappini, Stefania; Schifano, Fabrizio; Martinotti, Giovanni (2021-04-30) -
Editorial: Prescribing Psychotropics: Misuse, Abuse, Dependence, Withdrawal and Addiction-Volume II
Chiappini, Stephania; Schifano, Fabrizio; Martinotti, Giovanni (2022-10-18) -
Effects of fluorine substitution on the intermolecular interactions, energetics and packing behaviour of N-benzyl substituted diketopyrrolopyrroles
Calvo-Castro, Jesus; Morris, Graeme; Kennedy, Alan R.; McHugh, Callum J. (2016-04-06)Rationalizing the effects of molecular substitution in π-conjugated organic materials arising from well-defined intermolecular interactions, which can influence the formation of predefined packing motifs and control the ...