Browsing Research publications by Author "Extracellular Vesicle Research Unit"
Now showing items 81-100 of 151
-
Methods of Sentinel Lymph Node Detection and Management in Urinary Bladder Cancer—A Narrative Review
Sinha, Ankit; West, Alexander; Hayes, John; Teoh, Jeremy; Decaestecker, Karel; Vasdev, Nikhil (2022-02-23)Introduction: Detection of lymph node status in bladder cancer significantly impacts clinical decisions regarding its management. There is a wide range of detection modalities for this task, including lymphoscintigraphy, ... -
Micro throttle pump employing displacement amplification in an elastomeric substrate
Johnston, I. D.; Tracey, M.C.; Davis, J. B.; Tan, C. K. L. (2005-10)We report a micro throttle pump (MTP) with enhanced throttling resulting from beneficial deformation of its elastomer substrate. In the MTP reported, this has doubled the effective deflection of the piezo electric (PZT) ... -
Microfluidic solid phase suspension transport with an elastomer-based, single piezo-actuator, micro throttle pump
Johnston, I. D.; Tracey, M.C.; Davis, J. B.; Tan, C. K. L. (2005)We report a Micro Throttle Pump (MTP) which has been shown to pump 5 mm diameter polystyrene beads at a concentration of 4.5 x 10(7) beads ml(-1). This new MTP design is constructed in a straightforward manner and actuated ... -
Microfluidics based microcytometer: interfacing microfluidics with macrofluidics
Tracey, M.C.; Johnston, I.D.; Greenaway, R.; Sutton, N.; Doetzel, W.A. (Springer Nature, 1998) -
A microfluidics-based instrument for cytomechanical studies of blood
Tracey, M.C.; Sutton, N.; Johnston, I.D.; Doetzel, W.A. (Institute of Electrical and Electronics Engineers (IEEE), 2000) -
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Inal, Jameel (2018-11-23)The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of ... -
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review
Bassin, Jatinder; Dimitriadi, Maria; Cook, Michael T.; Abelha, Thais Fedatto; Calvo-Castro, Jesus (2022-12-27)Abstract: The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. ... -
Modelling a permanent magnet synchronous motor in FEniCSx for parallel high-performance simulations
McDonagh, James; Palumbo, Nunzio; Cherukunnath, Neeraj; Dimov, Nikolay; Yousif, Nada (2022-07-01)There are concerns that the extreme requirements of heavy-duty vehicles and aviation will see them left behind in the electrification of the transport sector, becoming the most significant emitters of greenhouse gases. ... -
Molecular basis for DarT ADP-ribosylation of a DNA base
Schuller, Marion; Butler, Rachel; Ariza, Antonio; Tromans-Coia, Callum; Jankevicius, Gytis; Claridge, Tim; Kendall, Sharon; Goh, Shan; Stewart, Graham; Ahel, Ivan (2021-08-26)ADP-ribosyltransferases use NAD+ to catalyse substrate ADP-ribosylation1, and thereby regulate cellular pathways or contribute to toxin-mediated pathogenicity of bacteria2–4. Reversible ADP-ribosylation has traditionally ... -
Multi-Channel Patterning of Antibodies on a Sensor Surface for Simultaneous Detection of Pathogens and Toxins
Davies, M. J.; McDonnell, M.B.; Johnston, I.D.; Perkins, E.A.; Tracey, M.C. (2010)This poster describes the development of a micro-engineered, PDMS/PMMA composite patterning device for the flow immobilisation of up to 16 separate antibody stripes on a single sensor chip surface. Results for a preliminary ... -
Multicenter Evaluation of Neoadjuvant and Induction Gemcitabine-Carboplatin versus Gemcitabine-Cisplatin Followed by Radical Cystectomy for Muscle-Invasive Bladder Cancer
Einerhand, Sarah MH; Black, Anna J; Zargar, Homayoun; Fairey, Adrian S.; Dinney, Colin P; Mir, Maria C; Krabbe, Laura-Maria; Cookson, Michael S.; Jacobson, Niels-Erik; Montgomery, Jeffrey S; Vasdev, Nikhil; Yu, Evan Y; Xylinas, Evanguelos; Kassouf, Wassim; Dall’Era, Marc A.; Sridhar, Srikala S.; McGrath, Jonathan S; Aning, Jonathan; Shariat, Shahrokh F; Wright, Jonathan L.; Thorpe, Andrew C.; Morgan, Todd M; Holzbeierlein, Jeff M.; Bivalacqua, Trinity J; North, Scott; Barocas, Daniel A.; Lotan, Yair; Grivas, Petros; Garcia, Jorge A; Stephenson, Andrew J; Shah, Jay B; Daneshmand, Simak; Zargar-Shoshtari, Kamran; Spiess, P. E.; van Rhijn, Bas W; Black, Peter C.; Mertens, L. S. (2022-09-28)PurposeCisplatin-based chemotherapy followed by radical cystectomy (RC) is recommended in patients with muscle-invasive bladder cancer (MIBC). However, up to 50% of patients are cisplatin-ineligible. The aim of this study ... -
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis
Riessland, Markus; Kaczmarek, Anna; Schneider, Svenja; Swoboda, Kathryn J; Löhr, Heiko; Bradler, Cathleen; Grysko, Vanessa; Dimitriadi, Maria; Hosseinibarkooie, Seyyedmohsen; Torres-Benito, Laura; Peters, Miriam; Upadhyay, Aaradhita; Biglari, Nasim; Kröber, Sandra; Hölker, Irmgard; Garbes, Lutz; Gilissen, Christian; Hoischen, Alexander; Nürnberg, Gudrun; Nürnberg, Peter; Walter, Michael; Rigo, Frank; Bennett, C Frank; Kye, Min Jeong; Hart, Anne C; Hammerschmidt, Matthias; Kloppenburg, Peter; Wirth, Brunhilde (2017-02-02)Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal genetic childhood motor neuron disease. SMN1 encodes SMN, a ubiquitous housekeeping protein, which makes the primarily motor neuron-specific ... -
Neurovascular structure-adjacent frozen-section examination robotic-assisted radical prostatectomy: outcomes from 500 consecutive cases in the UK
Noel, Jonathan; Spencer, Neil; Lodia, Siya; Karim, Seiver; Taneja, Surina; Moghanchizadeh, Darius; Nayak, Arvind; Tamhankar, Ashwin; Angra, Seema; Swamy, Rajiv; Agarwal, Samita; Narula, Ashish; Lane, Tim; Adshead, Jim; Vasdev, Nikhil (2021-10-30)The purpose is to report the United Kingdom’s largest single-centre experience of robotically assisted laparoscopic radical prostatectomies (RALP), using the neurovascular structure-adjacent frozen-section (NeuroSAFE) ... -
A new landscape of host–protozoa interactions involving the extracellular vesicles world
Gavinho, Bruno; Rossi, Izadora; Evans-Osses, Ingrid; Inal, Jameel; Ramirez, Marcel Ivan (2018-10-01)Extracellular vesicles (EVs) are released by a wide number of cells including blood cells, immune system cells, tumour cells, adult and embryonic stem cells. EVs are a heterogeneous group of vesicles (~30–1000 nm) including ... -
A North-West London Experience of the Impact of Treatment Related Toxicity on Clinical Outcomes of Elderly Patients with Germ Cell Tumors
Sharma, Anand; Morrison, Laura; Milic, Marina; Ghose, Aruni; Gogbashian, Andrew; Vasdev, Nikhil; Agarwal, Samita; Pullar, Ben; Rustin, Gordon (2022-10-11)Simple Summary: Germ cell testicular cancer is seen in men aged 15–35. Incidence of this cancer in the elderly aged > 45 is less than 10%. The aim of our retrospective study is to understand the treatment-related toxicity ... -
Novel gene loci associated with susceptibility or cryptic quantitative resistance to Pyrenopeziza brassicae in Brassica napus
Fell, Heather; Muthayil Ali, Ajisa; Wells, Rachel; Mitrousia, Georgia K.; Woolfenden, Hugh; Schoonbeek, Henk-jan; Fitt, Bruce D. L.; Ridout, Christopher J.; Stotz, Henrik U. (2023-03-23)Key message Quantitative disease resistance (QDR) controls the association of the light leaf spot pathogen with Brassica napus; four QDR loci that were in linkage disequilibrium and eight gene expression markers were ... -
A Novel Instrument for Studying the Flow Behaviour of Erythrocytes through Microchannels Simulating Human
Sutton, N.; Tracey, M.C.; Johnston, I.D.; Greenaway, R.; Rampling, M.W. (1997)A novel instrument has been developed to study the microrheology of erythrocytes as they flow through channels of dimensions similar to human blood capillaries. The channels are produced in silicon substrates using ... -
The Novel Phages phiCD5763 and phiCD2955 Represent Two Groups of Big Plasmidial Siphoviridae Phages of Clostridium difficile
Ramírez-Vargas, Gabriel; Goh, Shan; Rodríguez, César (2018-01-22)Until recently, Clostridium difficile phages were limited to Myoviruses and Siphoviruses of medium genome length (32–57 kb). Here we report the finding of phiCD5763, a Siphovirus with a large extrachromosomal circular ... -
Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
Tape, Christopher J.; Ling, Stephanie; Dimitriadi, Maria; McMahon, Kelly M.; Worboys, Jonathan D.; Leong, Hui Sun; Norrie, Ida C.; Miller, Crispin J.; Poulogiannis, George; Lauffenburger, Douglas A.; Jørgensen, Claus (2016-05-05)Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific ... -
The Oncological and Functional Prognostic Value of Unconventional Histology of Prostate Cancer in Localized Disease Treated with Robotic Radical Prostatectomy: An International Multicenter 5-Year Cohort Study
Leung, David; Castellani, Daniele; Nicoletti, Rossella; Vives Dilme, Roser; Mereno Sierra, Jesus; Serni, Sergio; Franzese, Carmine; Chiacchio, Giuseppe; Galosi, Andrea Benedetto; Mazzucchelli, Roberta; Palagonia, Erika; Dell'Oglio, Paolo; Galfano, Antonio; Bocciardi, Aldo Massimo; Zhao, Xue; Ng, Chi Fai; Lee, Hsiang-Ying; Sakamoto, Shinichi; Vasdev, Nikhil; Rivas, Juan Gomez; Campi, Riccardo; Teoh, Jeremy Yuen-Chun (2024-06-01)BACKGROUND AND OBJECTIVE: The impact of prostate cancer of unconventional histology (UH) on oncological and functional outcomes after robot-assisted radical prostatectomy (RARP) and adjuvant radiotherapy (aRT) receipt is ...