Browsing Research publications by Author "Pharmacology and Clinical Science Research"
Now showing items 21-40 of 107
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Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease
Ateh, D. D.; Hussain, I. K.; Mustafa, A. H.; Price, K. M.; Gulati, R.; Nickols, C. D.; Bird, M. M.; Greensmith, L.; Hafezparast, M.; Fisher, E. M. C.; Baker, C. S.; Martin, J. E. (2008-02)The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions. Here, the distribution of complex subunits in human central nervous ... -
The ‘EDHF’ Antagonist 14, 15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Vessels
MacKenzie, Louise Susan; Falck, John R.; Mitchell, Jane A. (2004-07)There is now overwhelming evidence for Epoxyeicosatrienoic acids (EETs) as endothelial derived hyperpolarising factor (EDHF). Most recently, a number of pharmacological tools have been developed for the study of EETs in ... -
The effects of 2,3-butanedione monoxime (BDM) on the force-velocity relation in single muscle fibres of the frog
Sun, Y-B.; Lou, Fang; Edman, K.A.P. (1995-04)The effects of 2,3-butanedione monoxime (BDM) on the force-velocity relation were studied in single fibres from the anterior tibialis muscle of Rana temporaria (2.2 microns sarcomere length, temperature 1.9-2.4 degrees C). ... -
Effects of Apamin and Charybdtoxin on Endothelium Independent Vasodilatation : Implications in the study of EDHF
MacKenzie, Louise Susan; Carrier, M.J.; Mitchell, J.A. (2005-12)Endothelial derived hyperpolarizing factor (EDHF), together with endothelial derived NO and prostacyclin represent the major endogenous vasodilator hormone pathways (Coleman et al, 2004). Since the chemical nature of EDHF ... -
Efficient Assessments : the Assessment Comparator a tool to calculate efficiency
Gormley-Fleming, Elizabeth; Lou, Fang (2013) -
Elastic energy storage and release in white muscle from dogfish scyliorhinus canicula
Lou, Fang; Curtin, N.A.; Woledge, R.C. (1999-01)The production of work by the contractile component (CC) and the storage and release of work in the elastic structures that act in series (the series elastic component, SEC) with the contractile component were measured ... -
Endotoxin detection in end-stage kidney disease
Wong, Jonathan; Jeraj, Hassan; Vilar, Enric; Viljoen, Adie; Farrington, Kenneth (2015-01-01)Aims: Endotoxin detection assays are not validated for use in end-stage kidney disease (ESKD). We investigated the accuracy and precision of the kinetic turbidimetric Limulus amoebocyte lysate (LAL) assay to detect endotoxin ... -
The Energetic Cost of Activation of White Muscle Fibres from the Dogfish Scyliophinus Canicula
Lou, Fang; Curtin, N.A.; Woledge, R.C. (1997)The energetic cost of activation was measured during an isometric tetanus of white muscle fibres from the dogfish Scyliorhinus canicula. The total heat production by the fibres was taken as a measure of the total energetic ... -
Evidence of improved fluid management in patients receiving haemodialysis following a self-affirmation theory based intervention : a randomised controlled trial
Wileman, Vari; Chilcot, Joseph; Armitage, Christopher J.; Farrington, Ken; Wellsted, D.; Norton, Sam; Davenport, Andrew; Franklin, Gail; Da Silva Gane, Maria; Horne, Robert; Almond, Mike (2016-01-02)Objective Haemodialysis patients are at risk of serious health complications, yet treatment non-adherence remains high. Warnings about health-risks associated with non-adherence may trigger defensive reactions. We studied ... -
Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Zloh, Mire; Perez Diaz, Noelia; Tang, Leslie; Patel, Pryank; MacKenzie, Louise Susan (2016-02-01)Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen ... -
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sarah; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-02-17)BACKGROUND: Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased ... -
Evidence That Self-Affirmation Improves Phosphate Control in Hemodialysis Patients : A Pilot Cluster Randomized Controlled Trial
Wileman, Vari; Farrington, Ken; Chilcot, Joseph; Norton, Sam; Wellsted, D.; Almond, Michael K.; Davenport, Andrew; Franklin, Gail; Gane, Maria Da Silva; Armitage, Christopher J. (2014-10)Hemodialysis patients are at risk of serious health complications, yet treatment non-adherence remains high. -
Exploring the views of patients not on the transplant waiting list : a qualitative study
Lawrence, Chris; Sharma, Shivani; Da Silva Gane, M.; Fletcher, Ben; Farrington, Ken (2013-06)Background: Not all patients are suitable for kidney transplantation; however, little is known about the views and attitudes of patients who are not on the waiting list for transplantation. Objective: This study aimed to ... -
The factor structure of the revised illness perception questionnaire (IPQ-R) in end-stage renal disease patients
Chilcot, Joseph; Norton, Sam; Wellsted, D.; Farrington, Ken (2012)The purpose of this study was to examine the factor structure of the Revised Illness Perceptions Questionnaire (IPQ-R) in a sample of 374 end-stage renal disease (ESRD) patients. A confirmatory factor analysis of the IPQ-R, ... -
Fukutin-related protein alters the deposition of laminin in the eye and brain
Ackroyd, M.R.; Whitmore, C.; Prior, S.; Kaluarachchi, M.; Nikolic, M.; Mayer, U.; Muntoni, F.; Brown, S.C. (2011-09-07)Mutations in fukutin-related protein (FKRP) are responsible for acommongroup of muscular dystrophies ranging from adult onset limb girdle muscular dystrophies to severe congenital forms with associated structural brain ... -
G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein product
Dhayan, Hansraj; Baydoun, A. R.; Kukol, A. (2014-10-15)G-quadruplexes are higher-order nucleic acid structures formed of square-planar arrangements of four guanine bases held together by Hoogsteen-type hydrogen bonds. Stacks of guanine tetrads are stabilised by intercalating ... -
Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential
Gorog, Diana; Yamamoto, J.; Inoue, N.; Otsui, K.; Ishii, H. (2014-05)BACKGROUND: Detection of both thrombosis and bleeding risk are essential in clinical cardiology. Thrombin generated by activated platelets and from the extrinsic coagulation pathway is the major determinant of thrombogenesis ... -
Haptoglobin beta chain isoforms in the plasma and peritoneal fluid of women with endometriosis
Ferrero, Simone; Gillott, David John; Remorgida, Valentino; Anserini, Paola; Price, Karen; Ragni, Nicola; Grudzinskas, Jurgis Gediminas (2005-05)To estimate the expression of haptoglobin (Hp) beta chain isoforms in the peritoneal fluid (PF) and plasma (PL) of women with and without endometriosis. -
Harnessing the benefits of PPARβ/δ agonists
MacKenzie, Louise Susan; Lione, Lisa (2013-12)Lipid mediators have complex effects on the cell; one of the key transcriptional factors that moderate proliferation and inflammatory effects is PPARβ/δ. Following highly successful clinical trials using the PPARβ/δ agonists ... -
Heat production and oxygen consumption during metabolic recovery of white muscle fibres from the dogfish Scyliorhinus canicula
Lou, Fang; van Der Laarse, W. J.; Curtin, N.A.; Woledge, R.C. (2000-04)Oxygen consumption and heat production were measured during contraction and recovery of isolated, white muscle fibres from dogfish (Scyliorhinus canicula) at 19 degrees C. The contraction period consisted of 20 isometric ...