Browsing Research publications by Author "Martin, G. P."
Now showing items 1-4 of 4
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The effect of aerodynamic particle size and solid state disorder on salmeterol xinafoate deposition from pressurised metered dose and dry powder inhaler formulations
Jaffari, S.; Sandhu, G.; Martin, G. P.; Forbes, B.; Collins, E.; Murnane, D. (2013-08)The production of active pharmaceutical ingredients (APIs) generally consists of crystallisation followed by a comminution process which provides limited control over particle size and energises particle surfaces. Both ... -
Effect of propylene glycol on in vitro membrane transport of ionized diclofenac diethylamine from saturated binary cosolvent mixtures
Benaouda, F.; Martin, G. P.; Jones, Stuart. A.; Brown, Marc (2008-09)For saturated formulations, where thermodynamic activity () is equal to 1, the flux of the permeant through a membrane should theoretically be constant irrespective of the delivery vehicle (Higuchi 1960). Although some ... -
Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments
Traynor, M.J.; Brown, Marc; Pannala, A.; Beck, P.; Martin, G. P. (2008)Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the ... -
Investigation of a reverse-phase high performance liquid chromatography (RP-HPLC) method for a weakly basic drug
Murnane, D.; Martin, G. P.; Marriott, C. (2005-09)Formulation development of combination drug products requires the availability of a rapid analytical method with low limits of detection, for the high-throughput analysis of the large number of samples generated. Salmeterol ...