Browsing Research publications by Author "Owen, D."
Now showing items 1-4 of 4
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Amyloid β-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures
Fonfria, E.; Marshall, I.C.B.; Boyfield, I.; Skaper, S.D.; Hughes, J.P.; Owen, D.; Zhang, W.; Miller, B.A.; Benham, C.D.; McNulty, S. (2005)Amyloid β-peptide (Aβ) is the main component of senile plaques which characterize Alzheimer's disease and may induce neuronal death through mechanisms which include oxidative stress. To date, the signalling pathways linking ... -
Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in organotypic hippocampal slices
Ray, A.; Owen, D.; Evans, M.L.; Davis, J.B.; Benham, C.D. (2000)We have explored the neuroprotective efficacy of the cell penetrant caspase inhibitor, Ac-YVAD-cmk, in a hippocampal slice model of neuronal cell death induced by oxygen and glucose deprivation. Organotypic hippocampal ... -
Characterization of the human HCN1 subunit and its inhibition by capsazepine
Gill, C.H.; Bates, S.A.; Owen, D.; Larkman, P.; Cairns, W.; Yusuf, S.; Murdock, P.; Strijbos, P.; Powell, A.; Benham, C.D.; Davies, C.H. (2004)The human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. ... -
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia
Fonfria, E.; Mattei, C.; Hill, K.; Brown, J.T.; Randall, A.D.; Benham, C.D.; Skaper, S.D.; Campbell, C.A.; Crook, B.; Murdoch, P.R.; Wilson, J.M.; Murio, F.P.; Owen, D.; Tilling, P.L.; McNulty, S. (2006)We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle ...