Browsing Research publications by Author "Pugh, W.J."
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The application of discriminant analysis and Machine Learning methods as tools to identify and classify compounds with potential as transdermal enhancers
Moss, Gary; Shah, A.J.; Adams, R.G.; Davey, N.; Sun, Y.; Wilkinson, S.C.; Pugh, W.J. (2012-01-23)Discriminant analysis (DA) has previously been shown to allow the proposal of simple guidelines for the classification of 73 chemical enhancers of percutaneous absorption. Pugh et al. employed DA to classify such enhancers ... -
Design, synthesis and characterisation of captopril prodrugs for enhanced percutaneous absorption
Moss, G.P.; Gullick, D.R.; Alexander, C.; Ingram, M.J.; Smart, J.D.; Pugh, W.J. (2006)Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for transdermal delivery. We were therefore interested in designing ... -
Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers
Pugh, W.J.; Wong, R.; Falson, F.; Michniak, B.B.; Moss, G.P. (2005)Structure-activity relationships were sought for 73 enhancers of hydrocortisone permeation from propylene glycol across hairless mouse skin. Enhancers had chain lengths (CC) from 0 to 16 carbon atoms, 1 to 8 H-bonding atoms ... -
Metabolism of captopril carboxyl ester derivatives for percutaneous absorption
Gullick, D.R.; Ingram, M.J.; Pugh, W.J.; Cox, P.A.; Gard, P.; Smart, J.D.; Moss, G.P. (2009)To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare ...