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PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation
(2021-12-17)
Background: Phosphoinositide-3-kinase-delta (PI3Kδ) inhibition is a promising therapeutic approach for inflammatory conditions due to its role in leucocyte proliferation, migration and activation. However, the effect of ...
Multi-disciplinary team-based simulation training in acute care settings: a systematic review of the impact on team performance
(2021-12-16)
Background: Teamwork plays an essential role in providing quality health care and ensuring good outcomes and safe practices in any health care system. This has been demonstrated in several studies in emergency care where ...
An Analog of the Feigin-Frenkel homomorphism for double loop algebras
(2021-12-15)
We prove the existence of a homomorphism of vertex algebras, from the vacuum Verma module over the loop algebra of an untwisted affine algebra, whose construction is analogous to that of the Feigin-Frenkel homomorphism ...
Efficacy and safety of the second in-hospital dose of tranexamic acid after receiving the prehospital dose: double-blind randomized controlled clinical trial in a level 1 trauma center
(2021-12-15)
Abstract: Background: Prehospital administration of tranexamic acid (TXA) to injured patients is increasing worldwide. However, optimal TXA dose and need of a second infusion on hospital arrival remain undetermined. We ...
GTC/CanariCam Deep Mid-infrared Imaging Survey of Northern Stars within 5 pc
(2021-12-15)
In this work we present the results of a direct imaging survey for brown dwarf companions around the nearest stars at the mid-infrared 10 micron range (λ c = 8.7 μm, Δλ = 1.1 μm) using the CanariCam instrument on the 10.4 ...
The nonlocal, local and mixed forms of the SPH method
(2021-12-15)
From its early days the SPH method has been criticised for its shortcomings namely tensile instability and consistency. Without thorough understanding of the method attempts were made to make the classical SPH method ...
Future Trends and Aging Analysis of Battery Energy Storage Systems for Electric Vehicles
(2021-12-14)
The increase of electric vehicles (EVs), environmental concerns, energy preservation, battery selection, and characteristics have demonstrated the headway of EV development. It is known that the battery units require special ...