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The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics
(1993-01-01)
The adverse cost in free energy of restricting an internal bond rotation in the binding of the peptide ligands N-succinyl-D-alanine and N-fumaryl-D-alanine to the antibiotic Ristocetin A, has been estimated to be 3.7 ± 0.9 ...
Toward an estimation of binding constants in aqueous solution : Studies of associations of vancomycin group antibiotics
(1993-01-01)
An approach toward the estimation of binding constants for organic molecules in aqueous solution is presented, based upon a partitioning of the free energy of binding. Consideration is given to polar and hydrophobic ...
Rational design and binding of modified cell-wall peptides to vancomycin-group antibiotics : Factorising free energy contributions to binding
(1993-01-01)
Modified cell-wall peptides have been rationally designed and studied in a semi-quantitative approach to factorising free energy contributions in binding to vancomycin-group antibiotics in aqueous solution. Binding energies ...