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Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
(2018-11-01)
First-generation immune checkpoint inhibitors, including anti-CTLA-4 and anti-programmed death 1 (anti-PD-1) antibodies, have led to major clinical progress, yet resistance frequently leads to treatment failure. Thus, new ...
A simulation tool for better management of retinal services
(2018-10-04)
Background: Advances in the management of retinal diseases have been fast-paced as new treatments become available, resulting in increasing numbers of patients receiving treatment in hospital retinal services. These patients ...
A novel method of non-clinical dispatch is associated with a higher rate of critical Helicopter Emergency Medical Service intervention
(2018-09-25)
Background - Helicopter Emergency Medical Services (HEMS) are a scarce resource that can provide advanced emergency medical care to unwell or injured patients. Accurate tasking of HEMS is required to incidents where advanced ...
In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails
(2018-09)
Background: Topical antifungal treatments for onychomycosis are applied to clean, unpolished nails for 48 weeks or longer. Patients often wish to mask their infection with nail polish yet there is no evidence to suggest ...
The future of robotic surgery
(2018-09-01)
For 20 years Intuitive Surgical’s da Vinci® system has held the monopoly in minimally invasive robotic surgery. Restrictive patenting, a well-developed marketing strategy and a high-quality product have protected the ...
Causes of ATtrition in CHIldren's NursinG (CATCHING): An exploratory mixed method study.
(2018-09)
Professional, financial and ethical reasons necessitate nursing improves its understanding of student attrition. Previous studies identify causes of attrition as multifactorial. However, few studies focus on children's ...
Sebomic identification of sex- and ethnicity-specific variations in residual skin surface components (RSSC) for bio-monitoring or forensic applications
(2018-08-21)
Background: “Residual skin surface components” (RSSC) is the collective term used for the superficial layer of sebum, residue of sweat, small quantities of intercellular lipids and components of natural moisturising factor ...
The impact of dementia on service use by individuals with a comorbid health condition: a comparison of two cross-sectional analyses conducted approximately ten-years apart
(2018-07-24)
Background The presence of concomitant medical conditions in people with dementia is common. Dementia may be related to differential use of health, social and informal care. Methods Data from two large UK population-based ...
Cognitive Behavioural Therapy for schizophrenia - outcomes for functioning, distress and quality of life : A meta-analysis
(2018-07-17)
Background: The effect of cognitive behavioural therapy for psychosis (CBTp) on the core symptoms of schizophrenia has proven contentious, with current meta-analyses finding at most only small effects. However, it has been ...
Work of the NHS England Youth Forum and its effect on health services.
(2018-07-11)
AIM: To examine the role of members of the NHS England Youth Forum (NHSEYF) and the strategies used to influence health service provision for children and young people. METHOD: An evaluative mixed-methods study was ...