Research publications: Recent submissions
Now showing items 1701-1720 of 9764
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Ig isotype switching in B lymphocytes : The effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma
(1991)The murine B cell lymphoma CH12.LX, which bears cell surface IgM specific for the phosphatidyl choline epitope of sheep red blood cells, is capable of spontaneous isotype switching in vitro. Switching to IgG3, IgG1, IgG2b, ... -
Involvement of the Sp3 transcription factor in induction of p21(Cip1/WAF1) in keratinocyte differentiation
(1997-01-25)The cyclin-dependent kinase inhibitor p21 is induced in several in vitro terminal differentiation systems as well as in differentiating tissues in vivo. To determine the mechanism responsible for p21 induction during ... -
Ig isotype switching in B lymphocytes : A method for estimating isotype switch frequency in cloned B cell lymphomas
(1989)We have developed a method for enumerating the frequency of Ig isotype switching in clones of B cells. The method adapts Poisson statistics to analyze the distribution of amounts of switched isotype produced by multiple ... -
E-cadherin expression can alter the specificity of gap junction formation
(1997-12-01)Specificity of gap junction formation produces communication compartments, groups of cells joined to each other by gap junctions (homologous communication) but more rarely to cells in adjacent compartments (heterologous ... -
Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation : Implications for the self-renewal of cutaneous epithelia
(1999-08-01)Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. ... -
Association between mouse nude gene expression and the initiation of epithelial terminal differentiation
(1999-04-15)Loss-of-function mutations in Whn (Hfh 11), a winged-helix/forkhead transcription factor, result in the nude mouse phenotype. To determine the whn expression pattern during development, we utilized mice in which a β- ... -
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation : Contrasting roles of FOXN1 and Akt
(2004-08-15)The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated ... -
β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
(2005-07-01)Using K14ΔNβ-cateninER transgenic mice, we show that short-term, low-level β-catenin activation stimulates de novo hair follicle formation from sebaceous glands and interfollicular epidermis, while only sustained, high-level ... -
Distinct epidermal stem cell compartments are maintained by independent niche microenvironments
(2006-09-01)The mammalian epidermis is a stratified, multilayered epithelium, consisting of the interfollicular epidermis and associated appendages, which extend into the dermis and include hair follicles, sebaceous glands, and sweat ... -
Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged : results from two UK inception cohorts
(2014-04-28)To assess whether there have been any secular changes in orthopedic interventions in patients with rheumatoid arthritis (RA) since 1986, as examined in 2 early rheumatoid arthritis (RA) inception cohorts with up to 25 years ... -
Understanding consumer evaluations of personalised nutrition services in terms of the privacy calculus : A qualitative study
(2014-06)Background: Personalised nutrition (PN) may provide major health benefits to consumers. A potential barrier to the uptake of PN is consumers' reluctance to disclose sensitive information upon which PN is based. This study ... -
Angel Among the Ruins : Group exhibition, Neue berliner Räume, Berlin
(Neue Berliner Räume, 2014-06)Curated by Ronit Eden for exhibition June 2014 “Angel Among the Ruins” brings together a group of international artists dealing with the very existence of the ruin as a social and political statement. In the exhibited art ... -
Hybrid Energies and Mutant Forms : the confessions of a pedagogical misfit
(2014-06)Offering a reflective narrative on the transformative effects of finding yourself ‘teaching in the wrong subject area’, this paper shows how sustained exploration of the shadowy realms between subject disciplines can bring ... -
Anna and the Tower : Multi Screen Video Installation
(Toronto International Film Festival, 2014-09-04)"Anna and the Tower" is a multi screen video installation co-commission with Toronto International Film Festival and the Goethe. "Anna and the Tower" is a fable of isolation and imaginative affect. Conflating documentary ... -
Anna and the Tower : Solo Exhibition, Toronto International Film Festival
(Toronto International Film Festival, 2014-09-04)"Anna and the Tower" is a co-commision with the Toronto International Film Festival and the Goethe Institute for exhibition as part of the 2014 International Festival. "Anna and the Tower" is a fable of isolation and ... -
L' avenir (Looking Forward) : Montreal Biennale 2014
(Montreal Biennale, 2014-10-21)"L’avenir (Looking Forward)" which will take place between October 21, 2014 and January 4, 2015. "Anna and the Tower : Multi Screen Video Installation" has been selected for exhibition as part of the Biennale. Curated by ... -
Design and baseline characteristics of the Food4Me study : a web-based randomised controlled trial of personalised nutrition in seven European countries
(2015-01-10)Improving lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing well-being. However, realising this ... -
Food hygiene challenges in older people : Intergenerational learning as a health asset
(WIT Press, 2013-05-28)Older people are more at risk of contracting foodborne infections; however the majority remain well despite the physical, social and cognitive challenges of older age. Future healthcare strategies targeting older people ...