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Effects of nano CuO on hippocampal neurons and differentiated PC12 cells

dc.contributor.authorXu, L.
dc.contributor.authorZhao, J.
dc.contributor.authorLiu, S.
dc.contributor.authorZhang, T.
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Z.
dc.date.accessioned2011-10-20T12:01:06Z
dc.date.available2011-10-20T12:01:06Z
dc.date.issued2008
dc.identifier.citationXu , L , Zhao , J , Liu , S , Zhang , T , Ren , G & Yang , Z 2008 , ' Effects of nano CuO on hippocampal neurons and differentiated PC12 cells ' , Acta Biophysica Sinica , vol. 24 , no. 2 , pp. 123-128 . < http://www.cjb.org.cn/ >
dc.identifier.issn1000-6737
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373285
dc.identifier.urihttp://hdl.handle.net/2299/6741
dc.descriptionOriginal article can be found at: http://www.cjb.org.cn/ Copyright Biophysical Society of China [Full text of this article is not available in the UHRA]
dc.description.abstractThe effects of nanoparticles of CuO on delayed rectifier potassium current (Ik) were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus by using the whole-cell patch-clamp techniques and the effects on differentiated PC12 cell viability were studied with MTT assay. Nanoparticles of CuO mainly inhibited Ik in the concentration of 5×10－5 g/mL. Nanoparticles of CuO didn't shift the steady-state activation curve of Ik but negatively shift the inactivation curve of Ik. Nanoparticles of CuO (5×10－4, 5×10－5 and 5×10－6 g/mL) induced differentiated PC12 cells damage with dose-and time-dependent manner.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofActa Biophysica Sinica
dc.subjectnanomaterial
dc.subjectdelayed rectifier potassium
dc.subjecthippocampal neurons
dc.subjectPC12
dc.subjectbiological effects
dc.titleEffects of nano CuO on hippocampal neurons and differentiated PC12 cellsen
dc.contributor.institutionMaterials and Structures
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionBioEngineering
dc.contributor.institutionCentre for Future Societies Research
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.cjb.org.cn/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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