| dc.contributor.author | Xu, L. | |
| dc.contributor.author | Zhao, J. | |
| dc.contributor.author | Liu, S. | |
| dc.contributor.author | Zhang, T. | |
| dc.contributor.author | Ren, Guogang | |
| dc.contributor.author | Yang, Z. | |
| dc.date.accessioned | 2011-10-20T12:01:06Z | |
| dc.date.available | 2011-10-20T12:01:06Z | |
| dc.date.issued | 2008 | |
| dc.identifier.citation | Xu , L , Zhao , J , Liu , S , Zhang , T , Ren , G & Yang , Z 2008 , ' Effects of nano CuO on hippocampal neurons and differentiated PC12 cells ' , Acta Biophysica Sinica , vol. 24 , no. 2 , pp. 123-128 . < http://www.cjb.org.cn/ > | |
| dc.identifier.issn | 1000-6737 | |
| dc.identifier.other | ORCID: /0000-0001-8865-1526/work/32373285 | |
| dc.identifier.uri | http://hdl.handle.net/2299/6741 | |
| dc.description | Original article can be found at: http://www.cjb.org.cn/ Copyright Biophysical Society of China [Full text of this article is not available in the UHRA] | |
| dc.description.abstract | The effects of nanoparticles of CuO on delayed rectifier potassium current (Ik) were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus by using the whole-cell patch-clamp techniques and the effects on differentiated PC12 cell viability were studied with MTT assay. Nanoparticles of CuO mainly inhibited Ik in the concentration of 5×10－5 g/mL. Nanoparticles of CuO didn't shift the steady-state activation curve of Ik but negatively shift the inactivation curve of Ik. Nanoparticles of CuO (5×10－4, 5×10－5 and 5×10－6 g/mL) induced differentiated PC12 cells damage with dose-and time-dependent manner. | en |
| dc.format.extent | 6 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Acta Biophysica Sinica | |
| dc.subject | nanomaterial | |
| dc.subject | delayed rectifier potassium | |
| dc.subject | hippocampal neurons | |
| dc.subject | PC12 | |
| dc.subject | biological effects | |
| dc.title | Effects of nano CuO on hippocampal neurons and differentiated PC12 cells | en |
| dc.contributor.institution | Materials and Structures | |
| dc.contributor.institution | School of Physics, Engineering & Computer Science | |
| dc.contributor.institution | Department of Engineering and Technology | |
| dc.contributor.institution | Centre for Engineering Research | |
| dc.contributor.institution | BioEngineering | |
| dc.description.status | Peer reviewed | |
| dc.identifier.url | http://www.cjb.org.cn/ | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
