| dc.contributor.author | Zhao, Yanjun | |
| dc.contributor.author | Khengar, Raj | |
| dc.contributor.author | Traynor, M.J. | |
| dc.contributor.author | Barata, Pedro | |
| dc.contributor.author | Brown, Marc | |
| dc.contributor.author | Jones, Stuart | |
| dc.date.accessioned | 2013-01-14T09:29:05Z | |
| dc.date.available | 2013-01-14T09:29:05Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Zhao , Y , Khengar , R , Traynor , M J , Barata , P , Brown , M & Jones , S 2012 , ' Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits ' , AAPS PharmSciTech , vol. 14 , no. 2 , pp. 218-224 . https://doi.org/10.1208/s12248-012-9325-x | |
| dc.identifier.issn | 1522-1059 | |
| dc.identifier.other | PURE: 737909 | |
| dc.identifier.other | PURE UUID: 4aa0e6db-8646-4131-8e87-d69c61a1c792 | |
| dc.identifier.other | Scopus: 84862819895 | |
| dc.identifier.other | ORCID: /0000-0001-7332-0011/work/32634798 | |
| dc.identifier.uri | http://hdl.handle.net/2299/9602 | |
| dc.description.abstract | The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK). | en |
| dc.language.iso | eng | |
| dc.relation.ispartof | AAPS PharmSciTech | |
| dc.title | Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits | en |
| dc.contributor.institution | Health & Human Sciences Research Institute | |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.contributor.institution | Department of Pharmacy | |
| dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
| dc.contributor.institution | Toxicology | |
| dc.contributor.institution | Pharmaceutics | |
| dc.contributor.institution | Nanopharmaceutics | |
| dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
| dc.contributor.institution | Skin and Nail Group | |
| dc.contributor.institution | Airway Group | |
| dc.contributor.institution | Bioadhesive Drug Delivery Group | |
| dc.description.status | Peer reviewed | |
| dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84862819895&partnerID=8YFLogxK | |
| rioxxterms.versionofrecord | https://doi.org/10.1208/s12248-012-9325-x | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
