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dc.contributor.authorZhao, Yanjun
dc.contributor.authorKhengar, Raj
dc.contributor.authorTraynor, M.J.
dc.contributor.authorBarata, Pedro
dc.contributor.authorBrown, Marc
dc.contributor.authorJones, Stuart
dc.date.accessioned2013-01-14T09:29:05Z
dc.date.available2013-01-14T09:29:05Z
dc.date.issued2012
dc.identifier.citationZhao , Y , Khengar , R , Traynor , M J , Barata , P , Brown , M & Jones , S 2012 , ' Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits ' , AAPS PharmSciTech , vol. 14 , no. 2 , pp. 218-224 . https://doi.org/10.1208/s12248-012-9325-x
dc.identifier.issn1522-1059
dc.identifier.otherPURE: 737909
dc.identifier.otherPURE UUID: 4aa0e6db-8646-4131-8e87-d69c61a1c792
dc.identifier.otherScopus: 84862819895
dc.identifier.otherORCID: /0000-0001-7332-0011/work/32634798
dc.identifier.urihttp://hdl.handle.net/2299/9602
dc.description.abstractThe intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK).en
dc.language.isoeng
dc.relation.ispartofAAPS PharmSciTech
dc.titlePharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbitsen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionToxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84862819895&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2012
rioxxterms.versionofrecordhttps://doi.org/10.1208/s12248-012-9325-x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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