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dc.contributor.authorZhao, Yanjun
dc.contributor.authorKhengar, Raj
dc.contributor.authorTraynor, M.J.
dc.contributor.authorBarata, Pedro
dc.contributor.authorBrown, Marc
dc.contributor.authorJones, Stuart
dc.identifier.citationZhao , Y , Khengar , R , Traynor , M J , Barata , P , Brown , M & Jones , S 2012 , ' Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits ' , AAPS PharmSciTech , vol. 14 , no. 2 , pp. 218-224 .
dc.identifier.otherPURE: 737909
dc.identifier.otherPURE UUID: 4aa0e6db-8646-4131-8e87-d69c61a1c792
dc.identifier.otherScopus: 84862819895
dc.identifier.otherORCID: /0000-0001-7332-0011/work/32634798
dc.description.abstractThe intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK).en
dc.relation.ispartofAAPS PharmSciTech
dc.titlePharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbitsen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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