UH Research Archive: Recent submissions
Now showing items 7381-7400 of 11145
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De novo ligand design to partially flexible active sites : Application of the Reflex algorithm to carboxypeptidase A, acetylcholinesterase, and the estrogen receptor
(2008-02)Reflex is a recent algorithm in the de novo ligand design software, SkelGen, that allows the flexibility of amino acid side chains in a protein to be taken into account during the drug-design process. In this paper the ... -
Objective Structured Clinical Examinations (OSCEs) compared With traditional assessment methods
(2011)Objectives: To compare objective structured clinical examinations (OSCEs) and traditional assessment methods among recent pharmacy graduates. Methods: Individual student performance in OSCEs was compared with performance ... -
Lipid models for united-atom molecular dynamics simulations of proteins
(2009)United-atom force fields for molecular dynamics (MD) simulations provide a higher computational efficiency, especially in lipid membrane simulations, with little sacrifice in accuracy, when compared to all-atom force fields. ... -
Revisiting the General Solubility Equation : In Silico Prediction of Aqueous Solubility Incorporating the Effect of Topographical Polar Surface Area
(2012-02)The General Solubility Equation (GSE) is a QSPR model based on the melting point and log P of a chemical substance. It is used to predict the aqueous solubility of nonionizable chemical compounds. However, its reliance on ... -
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems
(2008-06)Dementia with Lewy bodies (DLB) accounts for 15-20% of the millions of people worldwide with dementia. In the current work we investigate the association between proteasome dysfunction and the development of cortical Lewy ... -
Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation
(2011-12)A significant proportion of patients with Parkinson's disease (PD) receiving dopamine replacement therapy in the form of levodopa develop dyskinesia that becomes a major complicating factor in treatment. Dyskinesia can ... -
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets
(2008-05)L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation ... -
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response
(2008-08)The D2/D3 dopamine receptor agonist pramipexole, protects against toxin-induced dopaminergic neuronal destruction but its mechanism of action is unknown. Inflammation following glial cell activation contributes to cell ... -
An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat
(2009-04)Systemic administration of the proteasomal inhibitor I (PSI) to rats was reported to cause progressive nigral dopaminergic neuronal loss but this is disputed. A major controversy centres over the use of manual counting of ... -
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
(2009-10)Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ... -
Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
(2010-12)Hyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed ... -
Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates.
(2012-09-29)A rat respiratory epithelial cell culture system for in vitro prediction of drug pulmonary absorption is currently lacking. Such a model may however enhance the understanding of interspecies differences in inhaled drug ... -
The effect of processing variables on structural and mechanical properties of supercritical CO2 foamed scaffolds for tissue engineering
(2012-01)The porous structure of a scaffold determines the ability of bone to regenerate within this environment. In situations where the scaffold is required to provide mechanical function, balance must be achieved between optimizing ... -
Electronic prescribing reduced prescribing errors in a pediatric renal outpatient clinic
(2008)To assess the effect of an electronic prescribing (EP) system on the incidence and type of prescribing errors and the number of error-free visits. -
The incidence and nature of prescribing and medication administration errors in paediatric inpatients
(2010)Objectives: To determine the incidence and nature of prescribing and medication administration errors in paediatric inpatients. Design: Prospective review of drug charts to identify prescribing errors and prospective ... -
Post-transcriptional divergence in the regulation of CAT-2A, CAT-2B and iNOS expression by dexamethasone in vascular smooth muscle cells
(2012)Upregulation of l-arginine transport by pro-inflammatory mediators is a widely reported phenomenon which accompanies the expression of the inducible nitric oxide synthase (iNOS) enzyme in various cells. Both processes ... -
Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis
(2008-01)Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise for cardiac repair. However, poor viability of transplanted MSCs within the ischemic heart has limited their therapeutic potential. Our previous ... -
Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway
(2009)Background and Objectives: Mesenchymal stem cells (MSC) are multipotent progenitor cells that are have found use in regenerative medicine. We have previously observed that aspirin, a widely used anti-inflammatory drug, ... -
Detection of Cardiac Signal Characteristic Point Using Log-Domain Wavelet Transform Circuits
(2008-10)To meet the requirement of low power consumption in biomedical implantable pacemaker applications, a novel method based on balanced log-domain wavelet transform (WT) circuits has been developed for detecting QRS complexes ...