UH Research Archive: Recent submissions
Now showing items 7361-7380 of 11145
-
Using an embedded reality approach to improve test reliability for NHPT tasks
(Institute of Electrical and Electronics Engineers (IEEE), 2011)Research into the use of haptic and virtual reality technologies has increased greatly over the past decade, in terms of both quality and quantity. Methods to utilise haptic and virtual technologies with currently existing ... -
Histogram based classification of tactile patterns on periodically distributed skin sensors for a humanoid robot
(Institute of Electrical and Electronics Engineers (IEEE), 2011)The main target of this work is to improve human-robot interaction capabilities, by adding a new modality of sense, touch, to KASPAR, a humanoid robot. Large scale distributed skin-like sensors are designed and integrated ... -
Effect of using varying negative examples in transcription factor binding site predictions
(2011)Identifying transcription factor binding sites computationally is a hard problem as it produces many false predictions. Combining the predictions from existing predictors can improve the overall predictions by using ... -
Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
(2012)The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and ... -
Sensor materials for the detection of proteases
(2009-03-15)The concept of generic and tunable sensor materials for the detection of proteases based on the thin film degradation of peptide cross-linked dextran hydrogels was explored. Hydrogel cross-links were formed via simple imine ... -
Emergence and identification of new products of designer drug products from the internet
(2011)Designer drugs represent a rapidly expanding phenomenon particularly facilitated by their Internet availability. These drugs are continuously emerging as analogues of controlled substances (amfetamine, aminoindane, cathinone, ... -
Prescribing errors in hospital inpatients : a three-centre study of their prevalence, types and causes
(2011)To compare the prevalence and causes of prescribing errors in newly written medication orders and how quickly they were rectified, in three NHS organisations. -
Failure Mode and Effects Analysis : views of hospital staff in the UK
(2012)To explore health care professionals' experiences and perceptions of Failure Mode and Effects Analysis (FMEA), a team-based, prospective risk analysis technique. -
Failure mode and effects analysis too little for too much?
(2012)Failure mode and effects analysis (FMEA) is a structured prospective risk assessment method that is widely used within healthcare. FMEA involves a multidisciplinary team mapping out a high-risk process of care, identifying ... -
Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin A2
(2010)Protein–protein interactions are increasingly of interest as targets in small-molecule drug discovery. The interaction between the Ca2+- and phospholipid-binding protein Annexin A2 and its binding partner S100A10 has been ... -
Is failure mode and effect analysis reliable?
(2009)To test the reliability of failure mode and effect analysis (FMEA) within a hospital setting in the United Kingdom. -
Developing an environmentally benign process for the production of microparticles : Amphiphilic crystallization
(2008-05)The production of microparticles for inhalation typically employs jet-milling which can be destructive to the solid-state properties of the particles. The objective of the current work was to develop a crystallization ... -
Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystals
(2008-10)Purpose. To investigate the aerosolization and behaviour of microparticles of salmeterol xinafoate (SX) and fluticasone propionate (FP) suspended in hydrofluoroalkane (HFA) propellant. Methods. Microcrystals of SX and FP ... -
Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy
(2009-11-05)Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to simultaneously follow the diffusion of model drugs and solvent across polydimethylsiloxane (silicone) membrane. Three model ... -
ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes
(2010-02)The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. ... -
Thermodynamic considerations of solvent/enhancer uptake into a model membrane
(2010-08-30)The aim of this study was to conduct a thermodynamic analysts of the uptake of solvents into a model membrane as a precursor to skin transport studies. The investigation was designed so that the methodology may be applied ... -
In situ and Ex situ analysis of salmeterol xinafoate microcrystal formation from poly(ethylene glycol) 400 - Water cosolvent mixtures
(2008-06)Salmeterol xinafoate (SX) crystallization was investigated under different conditions of stirring, antisolvent addition, and supersaturation to identify factors limiting particle growth to enable the production of respirable ... -
Delivery of Peptides to the Blood and Brain after Oral Uptake of Quaternary Ammonium Palmitoyl Glycol Chitosan Nanoparticles
(2012-06)The clinical development of therapeutic peptides has been restricted to peptides for non-CNS diseases and parenteral dosage forms due to the poor permeation of peptides across the gastrointestinal mucosa and the blood-brain ... -
A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine(5)-enkephalin, to the brain
(2012-06)The oral use of neuropeptides to treat brain disease is currently not possible because of a combination of poor oral absorption, short plasma half-lives and the blood-brain barrier. Here we demonstrate a strategy for ... -
In Silico Prediction of Aqueous Solubility Using Simple QSPR Models : The Importance of Phenol and Phenol-like Moieties
(2012-10-28)Recently the authors published a robust QSPR model of aqueous solubility which exploited the computationally derived molecular descriptor topographical polar surface area (TPSA) alongside experimentally determined melting ...