UH Research Archive: Recent submissions
Now showing items 9701-9720 of 11146
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A potential anti-implantation and spermicidal strategy : Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity
(2006)We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to ... -
Design, synthesis and characterisation of captopril prodrugs for enhanced percutaneous absorption
(2006)Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for transdermal delivery. We were therefore interested in designing ... -
Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers
(2005)Structure-activity relationships were sought for 73 enhancers of hydrocortisone permeation from propylene glycol across hairless mouse skin. Enhancers had chain lengths (CC) from 0 to 16 carbon atoms, 1 to 8 H-bonding atoms ... -
A Personalised Assessment Programme in Engineering Education
(2010-09-22)The number of students entering higher education has grown considerably during the last decade. High student numbers and the attendant large class sizes present significant challenges for teachers. Such challenges include ... -
Recovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatography
(2010-09)Ion exchange chelation chromatography is an effective means to extract metals from coordination complexes and biological samples; however there is a lack of data to verify the nature of metal complexes that can be successfully ... -
A History of Doughty's Hospital, Norwich, 1687-2009
(University of Hertfordshire Press, 2010)Doughty’s Hospital, an almshouse in Norwich, was founded by a bequest in the will of William Doughty in 1687 and continues to thrive to this day. In this detailed history, the Hospital itself is contextualised within the ... -
Re-Thinking the Extended Mind: Moving Beyond the Machinery
(2010-09-15)Proponents of the Extended Mind Thesis (EMT) argue that the mind literally extends into the world because mental states literally extend into the world. But the arguments presented in favour of these claims are compatible ... -
Senior Selection Interviewing: From Individual Skill and Intuition to Habitus and Practice
(2010-09-15)Research into choosing individuals to fill positions at or near board level in organisations is scarce; however we know that interviewing is the dominant selection practice. The research into selection interviewing at ... -
Differential Effect of Helicobacter pylori Eradication on Time-Trends in Brady/Hypokinesia and Rigidity in Idiopathic Parkinsonism
(2010)Background: We examine the effect of eradicating Helicobacter in idiopathic parkinsonism (IP). Marked deterioration, where eradication-therapy failed, prompted an interim report in the first 20 probands to reach de-blinding. ... -
The Experience of Policymaking in Healthcare: The Interaction of Policy Formulation and Frontline Staff Practice
(2010-09-15)My research focuses on the experience of policy development and implementation. It draws on my involvement in a government policy taskforce, the development of an organisation’s strategy to the taskforce’s recommendations ... -
Firm Performance and Institutional Context: A Theoretical Exploration With Evidence From the Italian Cooperative Sector
(2010-09-15)This thesis examines the relationship between institutional context and firm performance, from both a theoretical and empirical perspective. The aim is to engage with the debate seeking to explain the observed diversity ... -
An international collaboration for the development of a research training course in an emergent academic discipline
(2010)In professional areas such as the creative and performing arts and design, the academic model of research has not been clearly articulated. This means that often the values held in advanced professional practice run counter ... -
Incontinence in women prisoners: an exploration of the issues
(2010)Aim. This paper is a report of a study exploring the extent and management of bladder and bowel problems in order to inform the provision and practice of prison nursing services and health care services in women’s prisons. ... -
Techniques to Assess Volume Status and Haemodynamic Stability in Patients on Haemodialysis
(2010-09-06)Volume overload is a common feature in patients on haemodialysis (HD). This contributes significantly to the cardiovascular disease burden seen in these patients. Clinical assessments of the volume state are often inaccurate. ... -
Beliefs About the Causes of Mental Illness and Attitudes Towards Seeking Help: A Study of British Jewry
(2010-09-03)Existing research and anecdotal accounts have consistently reported that Jewish people are positively inclined to seek treatment for mental health problems, including making use of psychiatric services and psychotherapy. ... -
Paths, Players, Places: Towards an Understanding of Mazes and Spaces in Videogames
(2010-08-25)This thesis contributes to the field of academic game studies by reworking and updating the established theories of Espen Aarseth, Janet Murray and Marie-Laure Ryan in understanding the path in videogames. It also draws ... -
Ice Crystal Classification Using Two Dimensional Light Scattering Patterns
(2010-08-23)An investigation is presented into methods of characterising cirrus ice crystals from in-situ light scattering data. A database of scattering patterns from modelled crystals was created using the Ray Tracing with Diffraction ... -
Studies of Depression and Illness Representations in End-Stage Renal Disease
(2010-08-20)Depression is a substantial psychopathology encountered in the dialysis population yet its association with potentially modifiable psychological antecedents are not well known. Of these potential antecedents, individual’s ... -
Textual Shakespeare: Writing and the Word
(University of Hertfordshire Press, 2003)'Textual Shakespeare' reassesses the Bard as a writer in the light of the late twentieth century 'revolution' in bibliography and textual studies. Reviewing recent debates in textual theory and practice, I conclude that ...