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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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2-oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis
Patel, Jessal; Bourne, Lucie E; Thakur, Shori; Farrington, Kenneth; Gorog, Diana; Orriss, Isabel R; Baydoun, Anwar (2020-09-12)Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ... -
3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
Iravani, Mahmoud M.; Jackson, M. J.; Kuoppamaki, M.; Smith, L. A.; Jenner, P. (2003-10-08)Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis ... -
3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor
Iravani, Mahmoud M.; Haddon, C. O.; Rose, S.; Jenner, P. (2006-01-05)The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation ... -
[3H]2-(2-Benzofuranyl)-2-imidazoline : a new selective high affinity radioligand for the study of rabbit brain imidazoline I2 receptors
Lione, Lisa; Nutt, D.J.; Hudson, A.L. (1996-05)This is the first study characterising the binding of the new imidazoline I2 receptor selective radioligand [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) to rabbit brain membranes. [3H]2-BFI binding was found to be saturable ... -
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
Murphy, K. P. S. J.; Carter, R. J.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J.; Lione, Lisa (2000-07-01)Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease ... -
Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model
Baines, Simon D.; O'Connor, Rachel; Saxton, Katie; Freeman, Jane; Wilcox, M. H. (2009)Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with ... -
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, Mahmoud M.; Leung, Clement C. M.; Sadeghian, Mona; Haddon, C. O.; Rose, Sarah; Jenner, P. (2005-07)Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposed human and in non-human ... -
Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction : role of altered serotonin metabolism
Keating, Christopher; Beyak, M.; Foley, S.; Singh, G.; Marsden, C.; Spiller, R.; Grundy, D. (2008-09)Visceral hypersensitivity is an important clinical feature associated with irritable bowel syndrome which in some patients has been linked to prior infection. Here we employ an animal model in which transient infection ... -
Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
El Mohsen, M. M. A.; Iravani, Mahmoud M.; Spencer, J. P. E.; Rose, S.; Fahim, A. T.; Motawi, T. M. K.; Ismail, N. A. F.; Jenner, P. (2005-10-21)The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation ... -
Ageing and gastrointestinal sensory function : altered colonic mechanosensory and chemosensory function in the aged mouse
Keating, Christopher; Grundy, David (2015)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood (1). A feature of ageing is impaired sensory perception, including a diminished sensory response to inflammatory ... -
Ageing and Gastrointestinal Sensory Function : The Enteric Nervous System
Keating, Christopher; Grundy, David (2016-07-06)Over the past few decades a combination of electrophysiological, morphological and molecular approaches has enabled the different populations of vagal and spinal afferents that innervate the bowel to be characterized. The ... -
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse.
Keating, Christopher; Nochi, Linda; Yu, Yang; Donovan, Jemma; Grundy, D (2016-08-14)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood. Here we investigated the effect of age upon gastrointestinal sensory signalling pathways in order to address the ... -
Alpha7 nicotinic receptor- mediated reduction of L-DOPA-induced dyskinesia in 6OHDA rat model of Parkinson’s Disease
Malekizadeh, Yasaman; Hassankhani, Kiana; Kingslake, Alice; Annett, Lucy; Shoaib, Mohammed; Iravani, Mahmoud (SAGE Publications, 2023-04-26)Introduction: In Parkinson’s Disease (PD) induction of involuntary movements (AIMs) or dyskinesia, after long-term L-DOPA therapy is a major problem. Evidence shows that nicotine can protect against nigrostriatal damage ... -
Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia
Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Lione, Lisa; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2017-05-17)Bladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and ... -
Analysis of 'legal high' substances and common adulterants using handheld spectroscopic techniques
Assi, Sulaf; Guirguis, Amira; Halsey, S.; Fergus, S.; Stair, J. L. (2015-01)The identification of 'legal highs' is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniques to be on-site, rapid ... -
Analysis of biofilm production and expression of adhesion structures of circulating Clostridioides difficile strains from Mexico
Adrian Martinez-Melendez, Adrian; Morfin-Otero, Rayo; Villarreal-Trevino, Licet; Baines, Simon; Camacho-Ortiz, Adrian; Garza-Gonzalez, Elvira (2021-03-10)Introduction Clostridioides difficile biofilms are believed to protect the pathogen from antibiotics, in addition to potentially contributing to recurrent infections. Methodology: Biofilm production of 102 C. difficile ... -
Analysis of SIGLEC12 expression, IMMUNOMODULATION and prognostic value in RENAL cancer using multiomic databases
Ogbodo, Amobichukwu K.; Mustafov, Denis; Arora, Mohit; Lambrou, George I.; Braoudaki, Maria; Siddiqui, Shoib (2024-01-30)Siglecs belong to a family of immune regulatory receptors predominantly found on hematopoietic cells. They interact with Sia, resulting in the activation or inhibition of the immune response. Previous reports have suggested ... -
Anopheles stephensi Dox-A2 shares common ancestry with genes from distant groups of eukaryotes encoding a 26S proteasome subunit and is in a conserved gene cluster
Garvey, C. F.; Malcolm, Colin (2000-06)The sequence of a cloned Anopheles stephensi gene showed 72% inferred amino acid identity with Drosophila melanogaster Dox-A2 and 93% with its putative ortholog in Anopheles gambiae. Dox-A2 is the reported but herein ... -
Anthracene based compounds and their uses
School of Life and Medical Sciences; Natural Product Chemistry and Drug Design; Centre for Research into Topical Drug Delivery and Toxicology; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Rossiter, Sharon; Kirton, Stewart; Camara, Ramatoulie (2016-11-17)