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Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
El Mohsen, M. M. A.; Iravani, Mahmoud M.; Spencer, J. P. E.; Rose, S.; Fahim, A. T.; Motawi, T. M. K.; Ismail, N. A. F.; Jenner, P. (2005-10-21)The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation ... -
Ageing and gastrointestinal sensory function : altered colonic mechanosensory and chemosensory function in the aged mouse
Keating, Christopher; Grundy, David (2015)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood (1). A feature of ageing is impaired sensory perception, including a diminished sensory response to inflammatory ... -
Ageing and Gastrointestinal Sensory Function : The Enteric Nervous System
Keating, Christopher; Grundy, David (2016-07-06)Over the past few decades a combination of electrophysiological, morphological and molecular approaches has enabled the different populations of vagal and spinal afferents that innervate the bowel to be characterized. The ... -
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse.
Keating, Christopher; Nochi, Linda; Yu, Yang; Donovan, Jemma; Grundy, D (2016-08-14)Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood. Here we investigated the effect of age upon gastrointestinal sensory signalling pathways in order to address the ... -
Alcohol/substance use and occupational/post-traumatic stress in paramedics
Hichisson, Andrew; Corkery, John (2020-10-02)Background: Paramedics work in high-pressure environments and experience traumatic events, which contribute to high levels of occupational and posttraumatic stress. Such stress can result in alcohol and substance misuse ... -
Allopurinol as a therapeutic option in cardiovascular disease
Okafor, Osita N; Farrington, K; Gorog, Diana A (2017-04-01)Epidemiological studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity also results in the formation of oxidative ... -
Alpha7 nicotinic receptor- mediated reduction of L-DOPA-induced dyskinesia in 6OHDA rat model of Parkinson’s Disease
Malekizadeh, Yasaman; Hassankhani, Kiana; Kingslake, Alice; Annett, Lucy; Shoaib, Mohammed; Iravani, Mahmoud (SAGE Publications, 2023-04-26)Introduction: In Parkinson’s Disease (PD) induction of involuntary movements (AIMs) or dyskinesia, after long-term L-DOPA therapy is a major problem. Evidence shows that nicotine can protect against nigrostriatal damage ... -
Alprazolam-related deaths in Scotland, 2004-2020
Corkery, John Martin; Guirguis, Amira; Chiappini, Stefania; Martinotti, Giovanni; Schifano, Fabrizio (2022-09-27)Background: The benzodiazepine drug alprazolam, a fast-acting tranquiliser, cannot be prescribed on the National Health Service in the United Kingdom. Illicit alprazolam supply and consumption have increased. Concern about ... -
Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia
Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Lione, Lisa; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2017-05-17)Bladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and ... -
Anabolic androgenic steroid abuse in the United Kingdom: An update
Mullen, Carrie; Whalley, Benjamin J; Schifano, Fabrizio; Baker, Julien S (2020-05)Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become recognised as potent image enhancement drugs. The primary goal of most abusers ... -
Analysis of 'legal high' substances and common adulterants using handheld spectroscopic techniques
Assi, Sulaf; Guirguis, Amira; Halsey, S.; Fergus, S.; Stair, J. L. (2015-01)The identification of 'legal highs' is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniques to be on-site, rapid ... -
An Analysis of Vascular Access Thrombosis Events From the Proactive IV irOn Therapy in hemodiALysis Patients Trial
PIVOTAL investigators and committees; Farrington, Kenneth (2022-08-01)Introduction: Treatment of anemia in dialysis patients has been associated with increased risk of vascular access thrombosis (VAT). Proactive IV irOn Therapy in hemodiALysis Patients (PIVOTAL) was a clinical trial of ... -
Angiotensin Converting Enzyme 2 may mediate disease severity in COVID-19
Gue, Ying X.; Kanji, Rahim; Gorog, Diana (2020-06-09)Identification of vulnerability to severe coronavirus disease 2019 (COVID-19) is extremely important and might allow optimised shielding and easing of lockdown. The disease is attributed to the severe acute respiratory ... -
Anthracene based compounds and their uses
School of Life and Medical Sciences; Natural Product Chemistry and Drug Design; Centre for Research into Topical Drug Delivery and Toxicology; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Rossiter, Sharon; Kirton, Stewart; Camara, Ramatoulie (2016-11-17) -
Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis
Jolly, Elaine C; Clatworthy, Menna R; Lawrence, Christopher; Nathan, Paul D; Farrington, Ken (2009-04-28)Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, ... -
Antibiotic Prescribing: A Retrospective Study from One English National Health Service (NHS) Foundation Trusts Before And During The COVID-19 Pandemic.
Abdelsalam Elshenawy, Rasha; Umaru, Nikkie; Aslanpour, Zoe (2023-06-20)This research by Abdelsalam Elshenawy Rasha., investigates antibiotic prescribing practices before and during the COVID-19 pandemic at an English NHS Trust. It focuses on understanding the implications of Antimicrobial ... -
Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape
Ghose, Aruni; Lapitan, Patricia; Apte, Vedika; Ghosh, Adheesh; Kandala, Abhinav; Basu, Sreejana; Parkes, Jo; Shinde, Sayali D; Boussios, Stergios; Sharma, Anand; Das, Prantik; Vasdev, Nikhil; Rebuzzi, Sara E; Ürün, Yüksel; Kanesvaran, Ravindran; Maniam, Akash; Banna, Giuseppe L (2024-04-23)Purpose of Review Our review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody–drug conjugate (ADC) development, emphasising their transformative ... -
Anticoagulation for Percutaneous Ventricular Assist Device-Supported Cardiogenic Shock JACC Review Topic of the Week
Vandenbriele, Christophe; Arachchillage, Deepa J.; Frederiks, Pascal; Giustino, Gennaro; Gorog, Diana A.; Gramegna, Mario; Janssens, Stefan; Meyns, Bart; Polzin, Amin; Scandroglio, Mara; Schrage, Benedikt; Stone, Gregg W.; Tavazzi, Guido; Vanassche, Thomas; Vranckx, Pascal; Westermann, Dirk; Price, Susanna; Chieffo, Alaide (2022-05-17)Interest in the use of mechanical circulatory support for patients presenting with cardiogenic shock is growing rapidly. The Impella (Abiomed Inc), a microaxial, continuous-flow, short-term, ventricular assist device (VAD), ... -
Anticoagulation in the ICU: a future for contact pathway inhibition?
Van Edom, Charlotte J; Gorog, Diana; Vandenbriele, Christophe (2023-07-31)Bleeding and thrombotic complications are the main cause of morbidity and mortality in critically ill patients on the intensive care unit (ICU), receiving short-term percutaneous mechanical circulatory support (pMCS) by ... -
Antidepressant Usage in Haemodialysis Patients: Evidence of Sub-optimal Practice Patterns
Guirguis, Ayman; Almond, Michael; Chilcot, Joseph; Davenport, A.; Wellsted, David; Farrington, Kenneth (2020-06-01)Background: Depression is common in patients on haemodialysis and associated with adverse outcomes. Antidepressant use is widespread though evidence of efficacy is limited. Objectives: To study antidepressant management ...