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Browsing by Author "Farrington, Kenneth"
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Intravenous Iron in Patients Undergoing Maintenance Hemodialysis
Macdougall, Iain C; White, Claire; Anker, Stefan; Bhandari, Sunil; Farrington, Kenneth; Kalra, Philip; McMurray, John; Murray, Heather; Tomson, Charles; Wheeler, David; Winearls, Christopher; Ford, Ian (2018-10-26)BACKGROUND: Intravenous iron is a standard treatment for patients undergoing hemodialysis, but comparative data regarding clinically effective regimens are limited. METHODS: In a multicenter, open-label trial with blinded ... -
Is Endotoxemia in Stable Hemodialysis Patients an Artefact? : Limitations of the Limulus Amebocyte Lysate Assay and Role of (1→3)-β-D Glucan
Wong, Jonathan; Zhang, Yonglong; Patidar, Ashish; Vilar, Enric; Finkelman, Malcolm; Farrington, Kenneth (2016-10-20)BACKGROUND: Elevated blood endotoxin levels are frequently reported in the dialysis population and are strongly linked with inflammation, a major predictor of mortality. Virtually all studies have employed the Limulus ... -
Measuring patients' experience with renal services in the UK: development and validation of the Kidney PREM
Hawkins, Janine; Wellsted, David; Corps, Claire; Fluck, Richard; Gair, Rachel; Hall, Natalie; Busby, Amanda; Rider, Beth; Farrington, Kenneth; Sharma, Shivani; Van Der Veer, Sabine (2022-08-01)Background: Patient experience is a recognized aspect of quality of care for people with chronic kidney disease (CKD), but current patient-reported experience measures (PREMs) only focus on dialysis care. We developed and ... -
Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection
Wong, Jonathan; Kaja Kamal, Raja Mohammed; Vilar, Enric; Farrington, Kenneth (2017-01-02)Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and ... -
Non-adherence to immunosuppressants following renal transplantation: a protocol for a systematic review
Hucker, Abigail; Bunn, Frances; Carpenter, Lewis; Lawrence, Christopher; Farrington, Kenneth; Sharma, Shivani (2017-09-28)Abstract Introduction Adherence to immunosuppressant medication is essential for renal transplant recipients. This review aims to summarise what is known about non-adherence, with a view to providing comprehensive evidence ... -
Nutritional and Non-nutritional Strategies in Bodybuilding: Impact on Kidney Function
Tidmas, V; Brazier, Jon; Hawkins, Janine; Forbes, S; Bottoms, Lindsay; Farrington, Kenneth (2022-04-03)Bodybuilders routinely engage in many dietary and other practices purported to be harmful to kidney health. The development of acute kidney injury, focal segmental glomerular sclerosis (FSGS) and nephrocalcinosis may be ... -
Patient Reported Experience of Kidney Care in the UK 2019
Hawkins, Janine; Busby, Amanda; Wellsted, David; Farrington, Kenneth (UK Renal Registry / Kidney Care UK, 2020-01-01)We are pleased to present the 2019 Kidney Patient Reported Experience Measure report (Kidney PREM). Following the initial pilot in 2016, involving over 8,000 people living with kidney disease, participation has continued ... -
Patient Reported Experience of Kidney Care in the UK 2020
Busby, Amanda; Hawkins, Janine; Mackintosh, Lucy; Wellsted, David; Farrington, Kenneth (UK Renal Registry / Kidney Care UK, 2021-05-14)Headline findings in 2020 • Encouragingly, despite the global pandemic, patients continue to rate their Overall Experience of the service provided by their renal centre highly. • Patient reported experience of Support and ... -
Patient Reported Experience of Kidney Care in the UK 2021
Busby, Amanda; Hawkins, Janine; Flanagan, Rebecca-Leigh; Mackintosh, Lucy; Wellsted, David; Farrington, Kenneth (UK Kidney Association, 2022-06-20)Headline findings • 12,416 people with kidney disease, from all 68 treating centres in the UK, took part in Kidney PREM this year, largely online. • Overall experience of kidney care continues to be rated highly, with many ... -
Patient Reported Experience of Kidney Care in the UK 2022
Busby, Amanda; Mackintosh, Lucy; Flanagan, Rebecca-Leigh; Wellsted, David; Farrington, Kenneth (UK Renal Registry / Kidney Care UK, 2023-05-25)Executive Summary This is the seventh annual report of the national Kidney PREM which is a measure of kidney patients’ self-reported experience of the care they receive from kidney centres. It provides people living with ... -
Plasma Levels of Middle Molecules to Estimate Residual Kidney Function in Haemodialysis without Urine Collection
Vilar, Enric; Boltiador, Capella; Wong, Jonathan; Viljoen, Adie; Machado, Ashwini; Uthayakumar, Arani; Farrington, Kenneth (2015-12-02)BACKGROUND: Residual Kidney Function (RKF) is associated with survival benefits in haemodialysis (HD) but is difficult to measure without urine collection. Middle molecules such as Cystatin C and β2-microglobulin accumulate ... -
Predicting residual kidney function in hemodialysis patients using serum β-trace protein and β2-microglobulin
Wong, Jonathan; Sridharan, Sivakumar; Berdeprado, Jocelyn; Viljoen, Adie; Vilar Hall, Enric; Wellsted, David; Farrington, Kenneth (2016-02-16)Residual kidney function (RKF) contributes significant solute clearance in hemodialysis patients. Kidney Diseases Outcomes Quality Initiative (KDOQI) guidelines suggest that hemodialysis dose can be safely reduced in those ... -
Prevalence and outcomes of chronic liver disease in patients receiving dialysis: systematic review and meta-analysis
Swift, Oscar; Sharma, Shivani; Ramanarayanan, Sivaramakrishnan; Umar, Hamza; Laws, Keith; Vilar, Enric; Farrington, Kenneth (2021-11-18)Background Patients receiving dialysis for end-stage kidney disease (ESKD) commonly co-exhibit risk factors for hepatic impairment. This systematic review and meta-analysis aimed to quantify the co-existence of chronic ... -
Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL) : Study design and baseline data
Macdougall, Iain C.; White, Claire; Anker, Stefan D.; Bhandari, Sunil; Farrington, Kenneth; Kalra, Philip A.; McMurray, John J.V.; Murray, Heather; Steenkamp, Retha; Tomson, Charles R.V.; Wheeler, David C.; Winearls, Christopher G.; Ford, Ian (2018-11-01)Background: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. Methods: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis ... -
Removal and rebound kinetics of cystatin C in high-flux hemodialysis and hemodiafiltration
Vilar, Enric; Boltiador, Capella; Viljoen, Adie; Machado, Ashwini; Farrington, Kenneth (2014-07-07)BACKGROUND AND OBJECTIVES: Cystatin C is a 13.3 kD middle molecule of similar size to β2-microglobulin and a marker of GFR in CKD. This study aimed to determine cystatin C kinetics in hemodialysis to understand whether ... -
The role of natriuretic peptides in volume assessment and mortality prediction in Haemodialysis patients
Sivalingam, Murugan; Vilar, Enric; Mathavakkannan, Suresh; Farrington, Kenneth (2015-12-29)BACKGROUND: Maintaining optimal fluid balance is essential in haemodialysis (HD) patients but clinical evaluation remains problematic. Other technologies such as bioimpedance are emerging as valuable adjuncts. This study ... -
Scaling Hemodialysis Target Dose to Reflect Body Surface Area, Metabolic Activity, and Protein Catabolic Rate : A Prospective, Cross-sectional Study
Sridharan, Sivakumar; Vilar, Enric; Davenport, Andrew; Ashman, Neil; Almond, Michael; Banerjee, Anindya; Roberts, Justin; Farrington, Kenneth (2017-03-01)BACKGROUND: Women and small men treated by hemodialysis (HD) have reduced survival. This may be due to use of total-body water (V) as the normalizing factor for dialysis dosing. In this study, we explored the equivalent ... -
Self-reported depression symptoms in haemodialysis patients: Bi-factor structures of two common measures and their association with clinical factors
Farrington, Kenneth; Chilcot, Joseph; Almond, Michael; Guirguis, ayman; Friedli, karin; Day, Clara; Davenport, Andrew; Wellsted, David (2018-09)Objective: To validate the factor structure of two common self-report depression tools in a large sample of haemodialysis (HD) patients and to examine their demographic and clinical correlates, including urine output, ... -
Stability of biochemical analytes of end stage renal failure patients on renal replacement therapy for urea-kinetic modeling in the home dialysis setting
Kar, Sourjya; Vilar, Enric; Farrington, Kenneth (2013-12-06) -
Ultra-endurance Participation and Acute Kidney Injury: A Narrative Review
Tidmas, Victoria; Brazier, Jon; Bottoms, Lindsay; Muniz, Daniel; Desai, Terun; Hawkins, Janine; Sridharan, Sivakumar; Farrington, Kenneth (2022-12-15)Increasingly popular, ultra-endurance participation exposes athletes to extremely high levels of functional and structural damage. Ultra-endurance athletes commonly develop acute kidney in-jury (AKI) and other pathologies ...