- UHRA Home
- Browsing by Author
Browsing by Author "Centre for Health Services and Clinical Research"
Now showing items 301-320 of 1038
-
Energy metabolism, body composition, and urea generation rate in hemodialysis patients
Sridharan, Sivakumar; Vilar, Enric; Berdeprado, Jocelyn; Farrington, Ken (2013-10-01)Hemodialysis (HD) adequacy is currently assessed using normalized urea clearance (Kt/V), although scaling based on Watson volume (V) may disadvantage women and men with low body weight. Alternative scaling factors such as ... -
Epidemiological Challenges in the Study of Behavioral Addictions: a Call for High Standard Methodologies
Rumpf, Hans Jürgen; Brandt, Dominique; Demetrovics, Zsolt; Billieux, Joël; Carragher, Natacha; Brand, Matthias; Bowden-Jones, Henrietta; Rahimi-Movaghar, Afarin; Assanangkornchai, Sawitri; Glavak-Tkalic, Renata; Borges, Guilherme; Lee, Hae Kook; Rehbein, Florian; Fineberg, Naomi; Mann, Karl; Potenza, Marc; Stein, Dan J.; Higuchi, Susumu; King, Daniel; Saunders, John B.; Poznyak, Vladimir (2019-06-27)The 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) categorizes gambling disorder in the section on substance-related and addictive disorders, and the 11th revision of the International ... -
Erdafitinib in BCG-treated high risk non-muscle invasive bladder cancer
Catto, James W.F.; Tran, Ben; Roupret, Morgan; Gschwend, Juergen E.; Loriot, Yohann; Nishiyama, Hiroyuki; Redorta, Joan P.; Daneshmand, Siamak; Hussain, Syed A.; Cutuli, Hernan J; Procopio, Giuseppe; Guadalupi, Valentina; Vasdev, Nikhil; Naini, Vahid; Crow, Lauren; Triantos, Spyros; Baig, Mahadi; Steinberg, Gary D. (2024-01-30)Background: Treatment options are limited for patients with high-risk non-muscle-invasive bladder cancer (NMIBC) with disease recurrence after bacillus Calmette–Guérin (BCG) treatment and who are ineligible for/refuse ... -
Establishing a clinical phenotype for cachexia in end stage kidney disease - study protocol
Reid, Joanne; Noble, Helen R; Adamson, Gary; Davenport, Andrew; Farrington, Ken; Fouque, Denis; Kalantar-Zadeh, Kamyar; Mallett, John; McKeaveney, C; Porter, S; Seres, David S; Shields, Joanne; Slee, Adrian; Witham, Miles D; Maxwell, Alexander P (2018-02-13)BACKGROUND: Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some ... -
Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compounds
Najib, Omaima N.; Martin, Gary P; Kirton, Stewart; Sallam, Al-Sayed; Murnane, Darragh (2016-06-15)The diffusion process through a non-porous barrier membrane depends on the properties of the drug, vehicle and membrane. The aim of the current study was to investigate whether a series of oily vehicles might have the ... -
Establishing the values for patient engagement (PE) in health-related quality of life (HRQoL) research: an international, multiple-stakeholder perspective
Haywood, Kirstie; Lyddiatt, Anne; Brace-McDonnell, Samantha J.; Staniszewska, Sophie; Salek, Mir-Saeed Shayegan (2016-12-08)PurposeActive patient engagement is increasingly viewed as essential to ensuring that patient-driven perspectives are considered throughout the research process. However, guidance for patient engagement (PE) in HRQoL ... -
Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: A Pandora Box to Explain Prognostic Differences
Kim, Hyun Kuk; Tantry, Udaya S.; Park, Hyun-Woong; Geisler, Tobias; Gorog, Diana; Gurbel, Paul A; Jeong, Young-Hoon (2021-03-01)Arterial and venous atherothrombotic events are finely regulated processes involving acomplex interplay between vulnerable blood, vulnerable vessel, and blood stasis.Vulnerable blood (‘thrombogenicity’) comprises complex ... -
Evaluating academic answers generated using ChatGPT
Fergus, Suzanne; Botha, Michelle; Ostovar, Mehrnoosh (2023-04-11)The integration of technology in education has become ever more prioritized since the COVID-19 pandemic. Chat Generative Pre-Trained Transformer (ChatGPT) is an artificial intelligence technology that generates conversational ... -
Evaluating alignment between Canadian Common Drug Review reimbursement recommendations and provincial drug plan listing decisions : an exploratory study
Allen, Nicola; Walker, Stuart R; Liberti, Lawrence; Sehgal, Chander; Salek, M Sam (2016-12-27)BACKGROUND: The CADTH Common Drug Review was established in 2002 to prepare national health technology assessment reports to guide listing decisions for 18 participating drug plans. The aim of this study was to compare the ... -
Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): Study protocol for a randomized controlled trial
Casarin, Annalisa; McAuley, D.F; Alce, T.M.; Zhao, Xiao B; Ely, E.W.; Jackson, J.C; McDowell, C; Agus, A; Murphy, L; Page, Valerie J (2015-05-16)Abstract Background The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The ... -
Evaluating health visitors’ existing knowledge of Down syndrome and the effect of a training workshop
Mengoni, Silvana; Redman, Sandra (2019-03-01)Children with Down syndrome are at an increased risk of health and development issues in early childhood, therefore monitoring their development and identifying health conditions as early as possible is critical. Health ... -
Evaluating Quality of Decision-Making Processes in Medicines' Development, Regulatory Review, and Health Technology Assessment : A Systematic Review of the Literature.
Bujar, M; McAuslane, N; Walker, S; Salek, Mir-Saeed Shayegan (2017-04-10)Introduction: Although pharmaceutical companies, regulatory authorities, and health technology assessment (HTA) agencies have been increasingly using decision-making frameworks, it is not certain whether these enable better ... -
Evaluation of a clinical pharmacy programme Japan-UK collaboration
Umaru, Nikkie; Kostrzewski, Andrzej; Echizen, Hirotoshi; Akazawa, Manabu; Aslanpour, Zoe; Dhillon, Soraya (2016-08-28)The development of Clinical Pharmacy in the United Kingdom (UK) has been established since the 1980's. The concept of pharmaceutical care has developed over the past 30 years and more recently the pharmacists role in ... -
Evaluation of a Whole System Approach to Diet and Healthy Weight in the East of Scotland: Study Protocol
Breslin, Gavin; Wills, Wendy; Bartington, Suzanne; Bontoft, Charis; Fakoya, Olujoke; Freethy, Imogen; Garcia Iglesias, Jaime; Howlett, Neil; Jones, Julia; Lebcir, Reda M.; Lloyd, Nigel; Newby, Katie; Smeeton, Nigel; Wagner, Adam; Wellings, Amander; Wellsted, David; Brown, Katherine (2022-03-24)Obesity is a global epidemic affecting all age groups, populations and income levels across continents. The causes of obesity are complex and are routed in health behaviours, environmental factors, government policy and ... -
Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): : a randomised, double-blind, placebo-controlled trial
Page, Valerie; Casarin, Annalisa; Ely, E.W; Zhao, Xiao B.; McDowell, Cliona; Murphy, Lynn; McAuley , Daniel F. (2017-07-19)Summary Background Delirium in critically ill patients is associated with poor clinical outcomes. Neuroinflammation might be an important mechanism in the pathogenesis of delirium, and since simvastatin has anti-inflammatory ... -
Evaluation of the Effectiveness and Efficiency of the East African Community Joint Assessment Procedure by Member Countries: The Way Forward
Ngum, Nancy; Mashingia, Jane; Ndomondo-Sigonda, Margareth; Walker, Stuart; Salek, Sam (2022-07-05)Background: For almost a decade, the East African Community has implemented the Medicines Regulatory Harmonization (EAC-MRH) programme among its member states to harmonise technical requirements and standards for medical ... -
Evaluation of the effectiveness and efficiency of the East African community joint assessment procedure by pharmaceutical companies: Opportunities for improvement
Ngum, Nancy; Mashingia, Jane; Ndomondo-Sigonda, Margareth; Walker, Stuart; Salek, Sam (2022-11-03)Background: A 2021 study to determine the viewpoints among the seven member countries regarding the effectiveness (i.e., achieving the intended outcomes) and efficiency (i.e., achieving the intended outcomes in timely ... -
An evaluation of the five rights antibiotic safety before and during COVID-19 at an NHS Foundation Trust in the United Kingdom
Elshenawy, Rasha Abdelsalam; Umaru, Nkiruka; Aslanpour, Zoe (2024-03-01)Introduction Antimicrobial Resistance (AMR) poses a significant global health threat, with AMR-related deaths projected to reach 10 million annually by 2050. The COVID-19 pandemic has further exacerbated this crisis. This ... -
Evaluation of the Good Review Practices of Countries Participating in the Southern African Development Community: Alignment and Strategies for Moving Forward
Sithole, Tariro; Mahlangu, Gugu; Capote, Velma; Sitoie, Tania; Shifotoka, Saren; Gaeseb, Johannes; Padayachee, Silverani; Sehloho, Tohlang; Khea, Akida; Fimbo, Adam; Munkombwe, Zuma; Mwale, Bernice; Salek, Sam; Walker, Stuart (2021-08-27)Introduction: National medicines regulatory agencies are faced with challenges including limited resources and technical capacity, resulting in countries collaborating and sharing resources to improve efficiency of the ... -
Evaluation of the move to remote delivery of drug and alcohol services during the COVID-19 pandemic: A study protocol
Lloyd, Nigel; Wills, Wendy; Bartington, Suzanne; Bontoft, Charis; Breslin, Gavin; Fakoya, Olujoke; Freethy, Imogen; Garcia-Iglesias, Jaime; Howlett, Neil; Jones, Julia; Newby, Katie; Smeeton, Nigel; Wagner, Adam; Wellings, Amander; Wellsted, David; Brown, Katherine (2022-07-31)Background: Substance misuse is a significant global health concern. In the UK, the prevalence of substance misuse has increased over the past decade and the number of alcohol and drug related deaths are increasing. ...