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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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NPS detection in Prison: a Systematic Literature Review of Use, Drug Form, and Analytical Approaches
Stair, Jacqueline; Vaccaro, Giorgia; Guirguis, Amira; Kirton, Stewart; Massariol, Anna (2022-03-30)This paper presents a systematic literature review on the detection of new psychoactive substances (NPS) in prison settings. It includes the most frequently reported NPS classes, the routes and forms used for smuggling, ... -
Objective Structured Clinical Examinations (OSCEs) compared With traditional assessment methods
Kirton, Stewart Brian; Kravitz, Laura (2011)Objectives: To compare objective structured clinical examinations (OSCEs) and traditional assessment methods among recent pharmacy graduates. Methods: Individual student performance in OSCEs was compared with performance ... -
Occurrence and distribution of neuropeptide Y (NPY)-immunoreactive nerves in rat isolated anococcygeus, and the effect of NPY on the inhibitory transmission
Iravani, Mahmoud M.; McDermott, J. R.; Turner, J. D.; Zar, M. A. (1987-10) -
Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
Tape, Christopher J.; Ling, Stephanie; Dimitriadi, Maria; McMahon, Kelly M.; Worboys, Jonathan D.; Leong, Hui Sun; Norrie, Ida C.; Miller, Crispin J.; Poulogiannis, George; Lauffenburger, Douglas A.; Jørgensen, Claus (2016-05-05)Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific ... -
Ongoing developments in CCP4 for high-throughput structure determination
Winn, M.D.; Ashton, A.W.; Briggs, P.J.; Ballard, C.C.; Patel, Pryank (2002-11)Collaborative Computational Project Number 4 (CCP4) was established in 1979 to promote collaboration between UK groups writing software for protein crystallography. From these beginnings, CCP4 now distributes a large ... -
Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
Mensah, Rosemond; Kirton, Stewart; Cook, Michael T.; Styliari, Ioanna Danai; Hutter, Victoria; Chau, David (2019-09-26)The objective of this study was to identify, understand and generate a Taguchi orthogonal array model for the formation of 10–50 μm microparticles with applications in topical/ocular controlled drug delivery. Poly(lactic ... -
Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells
Youness, Rana Ahmed; Al-Mahallawi, Abdulaziz Mohsen; Mahmoud, Farah Haytham; Atta, Hind; Braoudaki, Maria; Fahmy, Sherif Ashraf (2023-03-15)This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. ... -
An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology
Bading-Taika, Bayissi; Bouckandou, M; De Souza, Alain; Bourobou Bourobou, H.P.; MacKenzie, Louise; Lione, Lisa (2018-04-24)Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary ... -
Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro
Goh, Shan; Loeffler, Anette; Lloyd, David H; Nair, Sean P; Good, Liam (2015-11-11)BACKGROUND: Antibiotic resistance genes can be targeted by antisense agents, which can reduce their expression and thus restore cellular susceptibility to existing antibiotics. Antisense inhibitors can be gene and pathogen ... -
P2X 7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome
Keating, Christopher; Pelegrin, P.; Martínez, C.M.; Grundy, D. (2011-08-01)The ATP-gated P2X7 receptor (P2X7R) was shown to be an important mediator of inflammation and inflammatory pain through its regulation of IL-1β processing and release. Trichinella spiralis-infected mice develop a ... -
Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria
Passmore, Ian J; Letertre, Marine P M; Preston, Mark D; Bianconi, Irene; Harrison, Mark A; Nasher, Fauzy; Kaur, Harparkash; Hong, Huynh A; Baines, Simon D; Cutting, Simon M; Swann, Jonathan R; Wren, Brendan W; Dawson, Lisa F (2018-09-12)Clostridium difficile is a Gram-positive spore-forming anaerobe and a major cause of antibiotic-associated diarrhoea. Disruption of the commensal microbiota, such as through treatment with broad-spectrum antibiotics, is a ... -
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation
Gupta, Amit; Anjomani-Virmouni, Sara; Koundouros, Nikos; Dimitriadi, Maria; Choo-Wing, Rayman; Valle, Adamo; Zheng, Yuxiang; Chiu, Yu-Hsin; Agnihotri, Sameer; Zadeh, Gelareh; Asara, John M; Anastasiou, Dimitrios; Arends, Mark J; Cantley, Lewis C; Poulogiannis, George (2017-03-16)PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all ... -
Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains
Goh, Shan; Hussain, Haitham; Chang, Barbara J; Emmett, Warren; Riley, Thomas V; Mullany, Peter (2013-11-19)UNLABELLED: In this work, we show that Clostridium difficile phage ϕC2 transduces erm(B), which confers erythromycin resistance, from a donor to a recipient strain at a frequency of 10(-6) per PFU. The transductants were ... -
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology
Elemam, Noha M.; Mekky, Radwa Y.; Rashid, Gowhar; Braoudaki, Maria; Youness, Rana A. (2024-01-08)The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion ... -
Phenomenon of new drugs on the Internet : the case of ketamine derivative methoxetamine
Corazza, Ornella; Schifano, Fabrizio; Simonato, Pierluigi; Fergus, Suzanne; Assi, Sulaf; Stair, Jacqueline; Corkery, John; Trincas, Giuseppina; Deluca, Paolo; Davey, Zoe; Blaszko, Ursula; Demetrovics, Zsolt; Moskalewicz, Jacek; Enea, Aurora; di Melchiorre, Giuditta; Mervo, Barbara; Di Furia, Lucia; Farre, Magi; Flesland, Liv; Pasinetti, Manuela; Pezzolesi, Cinzia; Pisarska, Agnieszka; Shapiro, Harry; Siemann, Holger; Skutle, Arvid; Enea, Aurora; di Melchiorre, Giuditta; Sferrazza, Elias; Torrens, Marta; van der Kreeft, Peer; Zummo, Daniela; Scherbaum, Norbert (2012)On the basis of the material available both in the scientific literature and on the web, this paper aims to provide a pharmacological, chemical and behavioural overview of the novel compound methoxetamine. This is a ... -
Phospholemman Transmembrane Structure Reveals Potential Interactions with Na+/K+-ATPase
Beevers, A.J.; Kukol, A. (2007) -
Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch
Patel, Pryank; Prescott, Gerald R.; Burgoyne, Robert D; Lian, Lu-Yun; Morgan, Alan (2016-07-21)Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 chaperone family that localizes to neuronal synaptic vesicles. Impaired CSP function leads to neurodegeneration in humans and model organisms as a result of ... -
Physiological and Functional Changes in the Colon of MPTP-Treated Common Marmosets
Coletto, Erika; Tough, Ian; Hikima, Atsuko; Iravani, Mahmoud M.; Chaudhuri, K. Ray; Jenner, Peter; Cox, Helen; Rose, Sarah (2014-05)Objective: To determine changes in colon pathophysiology in MPTP-treated common marmosets. Background: Constipation is a common premotor symptom of Parkinson's disease (PD) and may be the result of changes in colonic ... -
Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice
Bading-Taika, Bayissi; Akinyeke, Tunde; Alcazar Maganad, Armando; Choie, Jaewoo; Ouanesisouk, Michael; Samson Torres, Eileen Ruth; Lione, Lisa; Maier, Claudia S.; Bobe, Gerd; Raber, Jacob; L. Miranda, Cristobal; Stevens, Jan F (2018-09-01)Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal ... -
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation
Sorif Uddin; Augustin Amour; Chris D Edwards; Matthew G Williamson; Simon Hall; Lione, Lisa; Edith M Hessel (2021-12-17)Background: Phosphoinositide-3-kinase-delta (PI3Kδ) inhibition is a promising therapeutic approach for inflammatory conditions due to its role in leucocyte proliferation, migration and activation. However, the effect of ...