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Now showing items 61-80 of 117
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In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig
Chilcott, Robert; Dalton, C. H.; Hill, I.; Davison, C. M.; Blohm, K. L.; Clarkson, E. D.; Hamilton, M. G. (2005-07)The purpose of this study was to characterize the skin absorption and distribution of VX (O-ethyl-S-[2 (diisopropylamino)ethyl] methylphosphonothioate) in the domestic pig in order to evaluate the animal as a potential ... -
Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments
Traynor, M.J.; Brown, Marc; Pannala, A.; Beck, P.; Martin, G. P. (2008)Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the ... -
Influence of surface geometry on the culture of human cell lines: a comparative study using flat, round-bottom and v-shaped 96 well plates
Shafaie, Sara; Hutter, Victoria; Brown, Marc; Cook, Michael; Chau, David (2017-10-30)In vitro cell based models have been invaluable tools for studying cell behaviour and for investigating drug disposition, toxicity and potential adverse effects of administered drugs. Within this drug discovery pipeline, ... -
Inter- and intralaboratory variation of in vitro diffusion cell measurements : An international multicenter study using quasi-standardized methods and materials
Chilcott, Robert; Barai, N; Beezer, A. E.; Brain, S I; Brown, Marc; Bunge, A L; Burgess, S E; Cross, S; Dalton, C H; Dias, M; Farinha, A; Finnin, B C; Gallagher, S J; Green, D M; Gunt, H; Gwyther, R L; Heard, C.M.; Jarvis, C A; Kamiyama, F; Kasting, G B; Ley, E E; Lim, S T; Mcnaughton, G S; Morris, A; Nazemi, M H; Pellett, M A; Du Plessis, J; Quan, Y S; Raghavan, S L; Roberts, M.; Romonchuk, W; Roper, C S; Schenk, D; Simonsen, L; Simpson, A; Traversa, B D; Trottet, L; Watkinson, A; Williams, F.M.; Wilkinson, S C; Yamamoto, A; Hadgraft, J. (2005-03)In vitro measurements of skin absorption are an increasingly important aspect of regulatory studies, product support claims, and formulation screening. However, such measurements are significantly affected by skin variability. ... -
Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation
Muddle, Joanna; Murnane, Darragh; Parisini, Irene; Brown, Marc; Page, Clive; Forbes, Ben (2015-11-01)A variety of capsule-based dry powder inhalers were used to evaluate formulation-device interaction. The in vitro deposition of salbutamol sulphate (SS) was compared directly to published data for salmeterol xinafoate (SX). ... -
Investigation into the functionality of controlled drug denaturing/destruction kits
Traynor, M.J. (2015-03)Context: Throughout the UK a large amount of unwanted, expired or patient returned controlled drugs are disposed of every day, in community and hospital pharmacies, veterinary surgeries, hospices, private hospitals and ... -
An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates
McAuley, W. J.; Jones, S. A.; Traynor, M.J.; Guesné, S.; Murdan, S.; Brown, Marc (2016-05)The treatment of onychomycosis remains problematic even though there are several potent antifungal agents available for patient use. The aim of this investigation was to understand if the structural modifications that arise ... -
Is ivrt alone sufficient to demonstrate 'sameness' of generic products?
Traynor, M.J.; Shetage, Satyajit S.; Wood, Daniel G.; Brown, Marc (Royal Society of Chemistry, 2014-04) -
Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies
Perez-Diaz, Noelia; Hoffman, Ewelina; Clements, Julie; Cruickshank, Rebecca; Doherty, Ann; Ebner, Daniel; Elloway, Joanne; Fu, Jianan; Kelsall, Joanne; Millar, Val; Saib, Ouarda; Scott, Andrew; Woods, Ian; Hutter, Victoria (2023-07-04)Introduction: In vitro approaches are an essential tool in screening for toxicity of new chemicals, products and therapeutics. To increase the reproducibility and human relevance of these in vitro assessments, it is advocated ... -
Managing mass casualties and decontamination
Chilcott, Robert (2014-11)Careful planning and regular exercising of capabilities is the key to implementing an effective response following the release of hazardous materials, although ad hoc changes may be inevitable. Critical actions which require ... -
Mass Casualty Decontamination in the United States : An Online Survey of Current Practice
Power, Sarah; Symons, Charles; Carter, Holly; Jones, Emma; Amlôt, Richard; Larner, Joanne; Matar, Hazem; Chilcott, Robert P (2016-08-01)Mass casualty decontamination is a public health intervention that would be employed by emergency responders following a chemical, biological, or radiological incident. The decontamination of large numbers of casualties ... -
Metabolism of Butoxyethanol in excised human skin in vitro
Traynor, M.J.; Wilkinson, S.C.; Williams, F.M. (2008)Glycol ethers are widely used in industrial and household applications because their chemical and physical properties make them versatile solvents, miscible with both water and organic media. Due to the ease with which the ... -
Modelling the oral cavity : In vitro and in vivo evaluations of buccal drug delivery systems
Patel, Viralkumar; Liu, Fang; Brown, Marc (2012-08)The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety ... -
Modified static diffusion cells for decontamination modelling
Larner, Joanne; Jones, David R.; Price, Shirley C.; Chilcott, Robert (2010-12-30) -
New insights into eutectic cream skin penetration enhancement
Fiala, Sarah; Roman, Marie; Inacio, Ricardo; Mashal, Sumaia; Brown, Marc B; Jones, Stuart A (2016-02-29)The manner in which the eutectic cream EMLA enhances the percutaneous penetration of lidocaine and prilocaine into human skin is still not fully understood. The purpose of this study was to investigate if the modification ... -
Non-invasive quantification of skin injury resulting from exposure to sulphur mustard and Lewisite vapours
Chilcott, Robert; Brown, Roger F. R.; Rice, P (2000-05)The severity and progression of skin lesions resulting from exposure to the chemical warfare agents Lewisite (L) and sulphur mustard (SM) have been investigated using the non-invasive biophysical methods of evaporimetry ... -
Octodrine: New Questions and Challenges in Sport Supplements
Catalani, Valeria; Prilutskaya, Mariya; Al-Imam, Ahmed; Marrinan, Shanna; Elgharably, Yasmine; Zloh, Mire; Martinotti, Giovanni; Chilcott, Robert; Corazza, Ornella (2018-02-20)Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has ... -
Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid
Frosini, Sian Marie; Bond, Ross; Loeffler, Annette; Larner, Joanne (2017-11-21)BACKGROUND: Staphylococcal infection of the canine epidermis and hair follicle is amongst the commonest reasons for antimicrobial prescribing in small animal veterinary practice. Topical therapy with fusidic acid (FA) is ... -
Optimisation of a dosing regime for a topical skin protectant (barrier cream)
Chilcott, Robert; Larner, Joanne; Matar, Hazem; Kansagra, Sneha; Theivendran, Baveetharan; Viegas, Vanessa Ann; Goldman, Virginia Streusand (2015)Context: Topical skin protectants (barrier creams) have the potential to reduce or enhance the severity of dermal lesions following exposure to allergens or irritants. Therefore, it is essential that such products are ... -
Optimisation of mass casualty decontamination procedures in vitro
Jones, David R.; Larner, Joanne; Price, Shirley C.; Chilcott, Robert (2010-12-30)