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Browsing by Author "Blyuss, Oleg"
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Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the UK Age RCT
Duffy, Stephen; Vulkan, Daniel; Cuckle, Howard; Parmar, Dharmishta; Sheikh, Shama; Smith, Robert; Evans, Andrew; Blyuss, Oleg; Johns, Louise; Ellis, Ian; Sasieni, Peter; Wale, Chris; Myles, Jonathan; Moss, Sue (2020-11-01)BACKGROUND: There remains disagreement on the long-term effect of mammographic screening in women aged 40-49 years.OBJECTIVES: The long-term follow-up of a randomised controlled trial that offered annual mammography to ... -
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer : A case-control study
Debernardi, Silvana; O'Brien, Harrison; Algahmdi, Asma S; Malats, Nuria; Stewart, Grant D; Plješa-Ercegovac, Marija; Costello, Eithne; Greenhalf, William; Saad, Amina; Roberts, Rhiannon; Ney, Alexander; Pereira, Stephen P; Kocher, Hemant M; Duffy, Stephen; Blyuss, Oleg; Crnogorac-Jurcevic, Tatjana (2020-12-10)BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally ... -
Comparative performance of MRI-derived PRECISE scores and delta-radiomics models for the prediction of prostate cancer progression in patients on active surveillance
Sushentsev, Nikita; Rundo, Leonardo; Blyuss, Oleg; Nazarenko, Tatiana; Suvorov, Aleksandr; Gnanapragasam, Vincent J.; Sala, Evis; Barrett, Tristan (2021-07-13)Objectives: To compare the performance of the PRECISE scoring system against several MRI-derived delta-radiomics models for predicting histopathological prostate cancer (PCa) progression in patients on active surveillance ... -
Concurrent participation in screening for cervical, breast, and bowel cancer in England
Rebolj, Matejka; Parmar, Dharmishta; Maroni, Roberta; Blyuss, Oleg; Duffy, Stephen W (2019-09-16)Objectives: To determine how many women participate in all three recommended cancer screening programmes (breast, cervical, and bowel). During their early 60s, English women receive an invitation from all the three programmes. ... -
Development of PancRISK, a urine biomarker-based risk score for stratified screening of pancreatic cancer patients
Blyuss, Oleg; Zaikin, Alexey; Cherepanova, Valeriia; Munblit, Daniel; Kiseleva, Elena M; Prytomanova, Olga M; Duffy, Stephen W; Crnogorac-Jurcevic, Tatjana (2019-12-20)BACKGROUND: An accurate and simple risk prediction model that would facilitate earlier detection of pancreatic adenocarcinoma (PDAC) is not available at present. In this study, we compare different algorithms of risk ... -
Effect of mammographic screening from age 40 years on breast cancer mortality (UK Age trial) : final results of a randomised, controlled trial
Duffy, Stephen W; Vulkan, Daniel; Cuckle, Howard; Parmar, Dharmishta; Sheikh, Shama; Smith, Robert A; Evans, Andrew; Blyuss, Oleg; Johns, Louise; Ellis, Ian O; Myles, Jonathan; Sasieni, Peter D; Moss, Sue M (2020-08-12)BACKGROUND: The appropriate age range for breast cancer screening remains a matter of debate. We aimed to estimate the effect of mammographic screening at ages 40-48 years on breast cancer mortality. METHODS: We did a ... -
Ensemble of correlation, parenclitic and synolitic graphs as a tool to detect universal changes in complex biological systems: Comment on "Dynamic and thermodynamic models of adaptation" by A.N. Gorban et al
Nazarenko, Tatiana; Blyuss, Oleg; Whitwell, Harry; Zaikin, Alexey (2021-09-01) -
Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes: A feasibility study
Pantelidou, Maria; Caglic, Iztok; George, Anne; Blyuss, Oleg; Gnanapragasam, Vincent J.; Barrett, Tristan (2022-09-09)Purpose: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. Methods: Single-centre prospective study of patients undergoing ... -
Excessive Media Consumption About COVID-19 is Associated With Increased State Anxiety : Outcomes of a Large Online Survey in Russia
Nekliudov, Nikita A.; Blyuss, Oleg; Cheung, Ka Yan; Petrou, Loukia; Genuneit, Jon; Sushentsev, Nikita; Levadnaya, Anna; Comberiati, Pasquale; Warner, John O.; Tudor-Williams, Gareth; Teufel, Martin; Greenhawt, Matthew; DunnGalvin, Audrey; Munblit, Daniel (2020-09-11)BACKGROUND: The COVID-19 pandemic has potentially had a negative impact on the mental health and well-being of individuals and families. Anxiety levels and risk factors within particular populations are poorly described. ... -
Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis
Korsunskiy, Ilya; Blyuss, Oleg; Gordukova, Maria; Davydova, Nataliia; Zaikin, Alexey; Zinovieva, Nataliia; Zimin, Sergey; Molchanov, Robert; Salpagarova, Aminat; Filipenko, Maxim; Eremeeva, Alina; Prodeus, Andrey; Korsunskiy, Anatoliy; Hsu, Peter; Munblit, Daniel (2020-03-03)Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early ... -
Faecal immunochemical testing in bowel cancer screening: Estimating outcomes for different diagnostic policies
Li, Shuping J.; Sharples, Linda D.; Benton, Sally C.; Blyuss, Oleg; Mathews, Christopher; Sasieni, Peter; Duffy, Stephen W. (2020-12-20)Objectives: The National Health Service Bowel Cancer Screening Programme (NHS BCSP) in England has replaced guaiac faecal occult blood testing by faecal immunochemical testing (FIT). There is interest in fully exploiting ... -
The Human Body as a Super Network : Digital Methods to Analyze the Propagation of Aging
Whitwell, Harry J.; Bacalini, Maria Giulia; Blyuss, Oleg; Chen, Shangbin; Garagnani, Paolo; Gordleeva, Susan Yu; Jalan, Sarika; Ivanchenko, Mikhail; Kanakov, Oleg; Kustikova, Valentina; Mariño, Ines P.; Meyerov, Iosif; Ullner, Ekkehard; Franceschi, Claudio; Zaikin, Alexey (2020-05-25)Biological aging is a complex process involving multiple biological processes. These can be understood theoretically though considering them as individual networks—e.g., epigenetic networks, cell-cell networks (such as ... -
Implementation of Multigene Germline and Parallel Somatic Genetic Testing in Epithelial Ovarian Cancer: SIGNPOST Study
Chandrasekaran, Dhivya; Sobocan, Monika; Blyuss, Oleg; Miller, Rowan E.; Evans, Olivia; Crusz, Shanthini M.; Mills-Baldock, Tina; Sun, Li; Hammond, Rory F. L.; Gaba, Faiza; Jenkins, Lucy A.; Ahmed, Munaza; Kumar, Ajith; Jeyarajah, Arjun; Lawrence, Alexandra C.; Brockbank, Elly; Phadnis, Saurabh; Quigley, Mary; El Khouly, Fatima; Wuntakal, Rekha; Faruqi, Asma; Trevisan, Giorgia; Casey, Laura; Burghel, George J.; Schlecht, Helene; Bulman, Michael; Smith, Philip; Bowers, Naomi L.; Legood, Rosa; Lockley, Michelle; Wallace, Andrew; Singh, Naveena; Evans, D. Gareth; Manchanda, Ranjit (2021-08-27)We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway of unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with ... -
Improved early detection of ovarian cancer using longitudinal multimarker models
Whitwell, Harry J.; Worthington, Jenny; Blyuss, Oleg; Gentry-Maharaj, Aleksandra; Ryan, Andy; Gunu, Richard; Kalsi, Jatinderpal; Menon, Usha; Jacobs, Ian; Zaikin, Alexey; Timms, John F. (2020-03-17)Background: Ovarian cancer has a poor survival rate due to late diagnosis and improved methods are needed for its early detection. Our primary objective was to identify and incorporate additional biomarkers into longitudinal ... -
Media Influence on Anxiety, Health Utility, and Health Beliefs Early in the SARS-CoV-2 Pandemic-a Survey Study
Greenhawt, Matthew; Kimball, Spencer; DunnGalvin, Audrey; Abrams, Elissa M; Shaker, Marcus S; Mosnaim, Giselle; Comberiati, Pasquale; Nekliudov, Nikita A; Blyuss, Oleg; Teufel, Martin; Munblit, Daniel (2021-02-24)Background: The psychological effects from the COVID-19 pandemic and response are poorly understood. Objective: To understand the effects of the pandemic and response on anxiety and health utility in a nationally representative ... -
MRI-derived radiomics model for baseline prediction of prostate cancer progression on active surveillance
Sushentsev, Nikita; Rundo, Leonardo; Blyuss, Oleg; Gnanapragasam, Vincent J; Sala, Evis; Barrett, Tristan (2021-06-21)Nearly half of patients with prostate cancer (PCa) harbour low- or intermediate-risk disease considered suitable for active surveillance (AS). However, up to 44% of patients discontinue AS within the first five years, ... -
Multi-marker longitudinal algorithms incorporating HE4 and CA125 in ovarian cancer screening of postmenopausal women
Gentry-Maharaj, Aleksandra; Blyuss, Oleg; Ryan, Andy; Burnell, Matthew; Karpinskyj, Chloe; Gunu, Richard; Kalsi, Jatinderpal K.; Dawnay, Anne; Marino, Ines P.; Manchanda, Ranjit; Lu, Karen; Yang, Wei Lei; Timms, John F.; Parmar, Max; Skates, Steven J.; Bast, Robert C.; Jacobs, Ian J.; Zaikin, Alexey; Menon, Usha (2020-07)Longitudinal CA125 algorithms are the current basis of ovarian cancer screening. We report on longitudinal algorithms incorporating multiple markers. In the multimodal arm of United Kingdom Collaborative Trial of Ovarian ... -
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential
Di Blasi, Roberto; Blyuss, Oleg; Timms, John F; Conole, Daniel; Ceroni, Francesca; Whitwell, Harry J (2021-02-19)Protein methylation is a key post-translational modification whose effects on gene expression have been intensively studied over the last two decades. Recently, renewed interest in non-histone protein methylation has gained ... -
Parenclitic and Synolytic Networks Revisited
Nazarenko, Tatiana; Whitwell, Harry J.; Blyuss, Oleg; Zaikin, Alexey (2021-10-20)Parenclitic networks provide a powerful and relatively new way to coerce multidimensional data into a graph form, enabling the application of graph theory to evaluate features. Different algorithms have been published for ... -
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention
Gaba, Faiza; Blyuss, Oleg; Liu, Xinting; Goyal, Shivam; Lahoti, Nishant; Chandrasekaran, Dhivya; Kurzer, Margarida; Kalsi, Jatinderpal; Sanderson, Saskia; Lanceley, Anne; Ahmed, Munaza; Side, Lucy; Gentry-Maharaj, Aleksandra; Wallis, Yvonne; Wallace, Andrew; Waller, Jo; Luccarini, Craig; Yang, Xin; Dennis, Joe; Dunning, Alison; Lee, Andrew; Antoniou, Antonis C; Legood, Rosa; Menon, Usha; Jacobs, Ian; Manchanda, Ranjit (2020-05-15)Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification ...