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Browsing by Author "Centre for Research into Topical Drug Delivery and Toxicology"
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14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor
Esposito, M.; Anaxagoras, T.; Larner, Joanne; Allinson, N.M.; Wells, K. (2013-01-07)14C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution ... -
3D and 4D Printing in Digital Healthcare
Awad, Atheer; Basit, Abdul W. (Springer Nature, 2023-08-05)Three-dimensional (3D) printing is a digital manufacturing system that is transforming pharmaceutical production by empowering patients to play an active role in the treatment process. Along with its dynamic form, namely, ... -
3D Characterisation of Dry Powder Inhaler Formulations: Developing X-ray Micro Computed Tomography Approaches
Gajjar, P; Styliari, I D; Nguyen, T T H; Carr, J; Chen, X; Elliott, J A; Hammond, R B; Burnett, T L; Roberts, K; Withers, P J; Murnane, D (2020-06)Carrier-based dry powder inhaler (DPI) formulations need to be accurately characterised for their particle size distributions, surface roughnesses, fines contents and flow properties. Understanding the micro-structure of ... -
3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in Pediatric Populations
Carou-Senra, Paola; Rodríguez-Pombo, Lucía; Monteagudo-Vilavedra, Einés; Awad, Atheer; Alvarez-Lorenzo, Carmen; Basit, Abdul W.; Goyanes, Alvaro; Couce, María L. (2023-12-25)The incidence of Inborn Error of Intermediary Metabolism (IEiM) diseases may be low, yet collectively, they impact approximately 6–10% of the global population, primarily affecting children. Precise treatment doses and ... -
3D Printing: Advancements in the Development of Personalised Pharmaceuticals for Older Adults
Awad, Atheer; Januskaite, Patricija; Alkahtani, Manal; Orlu, Mine; Basit, Abdul W. (Springer Nature, 2023-11-11)Three-dimensional (3D) printing is a revolutionary additive manufacturing technology that constructs objects layer-by-layer. This versatile technology encompasses various processes and possesses unique properties. While ... -
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro
Dalton, Christopher H.; Hattersley, Ian J.; Rutter, Stephen J.; Chilcott, Robert (2006-12)The physico-chemical properties of VX make the skin the most likely route of absorption into the human body. The development of effective medical countermeasures against such percutaneous threat agents relies on the use ... -
Acceptability in the Older Population: The Importance of an Appropriate Tablet Size
Vallet, Thibault; Michelon , Hugues; Orlu, Mine; Jani, Yogini Hariprasad; Leglise , Patrick; Laribe-Caget , Sandra; Piccoli, Matthieu; Le Fur , Aurélie; Liu, Fang; Ruiz , Fabrice; Boudy , Vincent (2020-08-08)Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia ... -
Acceptability of oral solid medicines in older adults with and without dysphagia : a nested pilot validation questionnaire based observational study
Liu, Fang; Ghaffur, Ambreen; Bains, Jackreet; Hamdy, Shaheen (2016-10-30)Older patients (aged 65 years and over) are the major consumers of medicines and many barriers affect their ability in taking medicines orally, especially swallowing difficulties. Moreover, the characteristics of differing ... -
Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
Active Targeting
Serrano Lopez, Dolores Remedios; Lalatsa, Lalatsa (Springer Nature, 2013) -
Advances in oral transmucosal drug delivery
Patel, Viralkumar F.; Liu, Fang; Brown, Marc (2011-07-30)The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ... -
Age-mediated changes in the gastrointestinal tract
Merchant, Hamid; Liu, Fang; Orlu Gul, Mine; Basit, Abdul (2016-10-30)Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of ... -
Amphiphilic poly(l-amino acids) : New materials for drug delivery
Lalatsa, Aikaterini; Schaetzlein, Andreas G.; Mazza, Mariarosa; Thi Bich Hang Le, [No Value]; Uchegbu, Ijeoma F. (2012-07-20)The formulation of drug compounds into medicines will increasingly rely on the use of specially tailored molecules, which fundamentally alter the drug's pharmacokinetics to enable its therapeutic activity. This is particularly ... -
Anthracene based compounds and their uses
School of Life and Medical Sciences; Natural Product Chemistry and Drug Design; Centre for Research into Topical Drug Delivery and Toxicology; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Rossiter, Sharon; Kirton, Stewart; Camara, Ramatoulie (2016-11-17) -
Apparatus, buffer and method for pH control
School of Life and Medical Sciences; Department of Clinical and Pharmaceutical Sciences; Centre for Research into Topical Drug Delivery and Toxicology; Pharmaceutics; Pharmaceutical Analysis and Product Characterisation; Bioadhesive Drug Delivery Group; Liu, Fang; Curl, Andrew; Fitzgerald , Dean (2019-04) -
The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
Moss, Gary; Sun, Yi; Wilkinson, Simon C.; Davey, N.; Adams, Roderick; Martin, Gary P.; Prapopopolou, M.; Brown, Marc (2011-11)Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ... -
The application of feature selection to the development of Gaussian process models for percutaneous absorption.
Lam, L.T.; Sun, Yi; Davey, N.; Adams, Roderick; Prapopoulou, M.; Brown, Marc; Moss, Gary (2010)Objectives: The aim was to employ Gaussian processes to assess mathematically the nature of a skin permeability dataset and to employ these methods, particularly feature selection, to determine the key physicochemical ... -
Application of sebomics for the analysis of residual skin surface components to detect potential biomarkers of type-1 diabetes mellitus
Shetage, Satyajit S; Traynor, Matthew J; Brown, Marc B; Galliford, Thomas M; Chilcott, Robert P (2017-08-21)Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate and ... -
Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro
Hoffman, Ewelina A; Gizelska, Katarzyna; Mirowski, Marek; Mielicki, Wojciech (2015-05-13)THE AIM OF THE STUDY: To analyze human breast cancer cell line MCF-7 and human malignant melanoma cell line WM-115 in order to characterize the cellular expression of CP and to evaluate whether ATO may affect this activity, ...