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14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor
Esposito, M.; Anaxagoras, T.; Larner, Joanne; Allinson, N.M.; Wells, K. (2013-01-07)14C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution ... -
2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol) : A preliminary review
Corkery, John; Schifano, Fabrizio; Ghodse, A. Hamid; Elliott, S.; Corazza, Ornella (2012)2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol) are psychoactive substances, sold primarily over the Internet and in 'head' shops ... -
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections
Tasdemir, Deniz; Sanabria, David; Lauinger, Ina L; Tarun, Alice; Herman, Rob; Perozzo, Remo; Zloh, Mire; Kappe, Stefan H.; Brun, Reto; Carballeira, Néstor M (2010)Acetylenic fatty acids are known to display several biological activities, but their antimalarial activity has remained unexplored. In this study, we synthesized the 2-, 5-, 6-, and 9-hexadecynoic acids (HDAs) and evaluated ... -
2β-Acetoxyferruginol - A new antibacterial abietane diterpene from the bark of Prumnopitys andina
Smith, E.C.J.; Gibbons, S.; Wareham, N.; Zloh, Mire (2008-04-15)As part of an on-going project to isolate antibacterial compounds from rare conifer species, a new abietane diterpene, 2β-acetoxyferruginol was isolated from the stem bark of Prumnopitys andina. Molecular modelling studies ... -
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
5.08 Drug Delivery across the Blood-brain barrier
Lalatsa, Aikaterini (Elsevier, 2011) -
Accelerated metabolite identification by "Extraction-NMR"
Gerhard, U.; Thomas, S.; Mortishire-Smith, R. (2003-07-14)Examples of the use of extraction-NMR, an efficient and rapid method to obtain structural information on metabolites without prior separation, are described. Crude ethyl acetate extracts of in vitro microsomal incubations ... -
Acid unfolding of beta-2-microglobulin by repulsion of + charges
Bray, P.; Vucic, M.; Zloh, Mire; Vucelic, D. (1988-07) -
Aconityl-derived polymers for biomedical applications : Modeling study of cis-trans isomerisation
Zloh, Mire; Dinand, E.; Brocchini, S. (2003-05-01)Soluble polymers have been prepared that are designed to undergo enhanced rates of hydrolysis at pH values less than that observed in blood circulation. The degradable element in the polymer mainchain is derived from ... -
Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
Active Targeting
Serrano Lopez, Dolores Remedios; Lalatsa, Lalatsa (Springer Nature, 2013) -
Acyclovir-valaciclovir equilibrium between peritoneal fluid and plasma
Stathoulopoulou, F.; Dhillon, S.; Stathakis, C.; Stamatiadis, D. (2001) -
Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells
Errington, Rachel J.; Ameer-Beg, S. M.; Vojnovic, B.; Patterson, Laurence H.; Zloh, Mire; Smith, P. J. (2005)Many anticancer drugs require interaction with DNA or chromatin components of tumor cells to achieve therapeutic activity. Quantification and exploration of drug targeting dynamics can be highly informative in the rational ... -
Advances in oral transmucosal drug delivery
Patel, Viralkumar F.; Liu, Fang; Brown, Marc (2011-07-30)The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ... -
Adverse Drug Reactions in Children - International Surveillance and Evaluation (ADVISE) : A Multicentre Cohort Study
Rashed, Asia N.; Wong, Ian C. K.; Cranswick, Noel; Hefele, Barbara; Tomlin, Stephen; Jackman, John; Lee, Kenneth; Hon, Kam-Lun E.; Ong, Jeffrey; Ghaleb, Maisoon; Chua, Slew Siang; Hui, Tea Ming; Rascher, Wolfgang; Neubert, Antje (2012)Background: A previous meta-analysis reported that 9.5% of hospitalized children suffered from an adverse drug reaction (ADR); however, reported incidences among studies varied. Objective: To enhance the knowledge of ADRs ... -
An Alternative Method for Providing an Inter-professional Educational (IPE) Experience to Overseas Pharmacists Assessment Programme (OSPAP) Students
Mason, Susanna; Cowan, Louise (2013-09)Can a video-recorded role-play session benefit OSPAP students in providing patient-centred care within the interprofessional team? -
An Alternative Method for Providing an Inter-professional Educational (IPE) Experience to Overseas Pharmacists Assessment Programme (OSPAP) Students
Mason, Susanna; Cowan, Louise (2013) -
Amanicadol, a pimarane-type diterpene from Phlomis amanica Vierch
Yalçin, F.N.; Ersöz, T.; Çaliş, I.; Bedir, E.; Dönmez, A.A.; Stavri, M.; Gibbons, S.; Zloh, Mire (2006-11-01)Fractionation of the methanol extract of Phlomis amanica resulted in the isolation of a new pimarane type diterpene, amanicadol (1), together with the known glycosides lamiide, verbascoside (= acteoside), syringaresinol-4-O-β- ... -
Amphiphilic poly(l-amino acids) : New materials for drug delivery
Lalatsa, Aikaterini; Schaetzlein, Andreas G.; Mazza, Mariarosa; Thi Bich Hang Le, [No Value]; Uchegbu, Ijeoma F. (2012-07-20)The formulation of drug compounds into medicines will increasingly rely on the use of specially tailored molecules, which fundamentally alter the drug's pharmacokinetics to enable its therapeutic activity. This is particularly ... -
Analisi dei report online relativi al potenziale uso errato della benzidamina
Schifano, Fabrizio; Corazza, Ornella; Marchi, Alessandro; di Melchiorre, Giuditta; Sferrazza, Elias; Enea, Aurora; Davey, Z.; Blaszko, Ursula; Deluca, Paolo (2013)Benzydamine/Tantum Rosa is a drug for external use. It is typically available in Europe, without the need of a medical prescription, for the treatment of vaginal inflammatory processes. Between December 2009 and January ...