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Browsing by Author "McAuley, W. J."
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ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes
McAuley, W. J.; Lad, M. D.; Mader, K. T.; Santos, P.; Tetteh, J.; Kazarian, S. G.; Hadgraft, J.; Lane, M. E. (2010-02)The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. ... -
Human Nail Plate Modifications Induced by Onychomycosis : Implications for Topical Therapy
Baraldi, A.; Jones, S. A.; Guesné, S.; Traynor, M.J.; McAuley, W. J.; Brown, Marc; Murdan, S. (2015-05-01)Conclusions: Onchomycotic nails presented a thicker but more porous barrier, and its eroded intracellular matrix rendered the tissue more permeable to topically applied chemicals when an aqueous vehicle was used.Purpose: ... -
An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates
McAuley, W. J.; Jones, S. A.; Traynor, M.J.; Guesné, S.; Murdan, S.; Brown, Marc (2016-05)The treatment of onychomycosis remains problematic even though there are several potent antifungal agents available for patient use. The aim of this investigation was to understand if the structural modifications that arise ... -
Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
Mader, K. T.; Tetteh, J.; McAuley, W. J.; Lane, M. E.; Hadgraft, J.; Andanson, J. M.; Kazarian, S. G. (2010-10)ATR-FTIR spectroscopic imaging permeation experiments of a model formulation across stratum corneum (SC) were conducted to acquire further understanding of the mechanism of drug permeation. Quantitative iterative target ... -
Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis
Tetteh, J.; Mader, K. T.; Andanson, J. M.; McAuley, W. J.; Lane, M. E.; Hadgraft, J.; Kazarian, S. G.; Mitchell, J. C. (2009-05-29)In the context of trans-dermal drug delivery it is very important to have mechanistic insight into the barrier function of the skin's stratum corneum and the diffusion mechanisms of topically applied drugs. Currently ... -
Opto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivo
Xiao, P.; Zheng, X.; Imhof, R. E.; Hirata, K.; McAuley, W. J.; Mateus, R.; Hadgraft, J.; Lane, M. E. (2011-03-15)This work describes the first application of Opto-Thermal Transient Emission Radiometry (OTTER), an infrared remote sensing technique, to probe the extent to which solvents permeate the human nail in vivo. Decanol, glycerol ... -
Reduced skin permeation and penetration of clobetasol propionate when Dermovate cream is applied at short time intervals with emollients
Beebeejaun, M. T.; Brown, M. B.; Hutter, V.; Kravitz, L.; McAuley, W. J. (2023-07-02)Background: Dermovate cream containing 0.05% clobetasol propionate is a very potent topical corticosteroid (TCS) used in the treatment of severe inflammatory dermatoses. Regular emollient therapy should continue alongside ... -
Thermodynamic considerations of solvent/enhancer uptake into a model membrane
McAuley, W. J.; Oliveira, G.; Mohammed, D.; Beezer, A. E.; Hadgraft, J.; Lane, M. E. (2010-08-30)The aim of this study was to conduct a thermodynamic analysts of the uptake of solvents into a model membrane as a precursor to skin transport studies. The investigation was designed so that the methodology may be applied ...