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Browsing by Author "Moss, G.P."
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Design, synthesis and characterisation of captopril prodrugs for enhanced percutaneous absorption
Moss, G.P.; Gullick, D.R.; Alexander, C.; Ingram, M.J.; Smart, J.D.; Pugh, W.J. (2006)Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for transdermal delivery. We were therefore interested in designing ... -
Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers
Pugh, W.J.; Wong, R.; Falson, F.; Michniak, B.B.; Moss, G.P. (2005)Structure-activity relationships were sought for 73 enhancers of hydrocortisone permeation from propylene glycol across hairless mouse skin. Enhancers had chain lengths (CC) from 0 to 16 carbon atoms, 1 to 8 H-bonding atoms ... -
Effect of occlusion on the percutaneous penetration of linoleic acid and glycerol
Taylor, L.J.; Lee, R.S.; Long, M.; Rawlings, A.V.; Tubek, J.; Whitehead, L.; Moss, G.P. (2002)The effect of occlusion on the in vitro percutaneous absorption of linoleic acid was investigated. A greater skin concentration of linoleic acid from an ethanolic vehicle was observed in non-occluded experiments compared ... -
In vitro transdermal delivery of caffeine, theobromine, theophylline and catechin from extract of Guarana, Paullinia Cupana
Heard, C.M.; Johnson, S.; Moss, G.P.; Thomas, C.P. (2006) -
Mechanical characterisation and drug permeation properties of tetracaine-loaded bioadhesive films for percutaneous local anaesthesia
Moss, G.P.; Woolfson, A.D.; Gullick, D.R.; McCafferty, D.F. (2006)In the development of bioadhesive patch devices for percutaneous local anesthesia, the tensile properties of the films produced after the casting of the gel intermediates is of key importance to the clinical compliance of ... -
Metabolism of captopril carboxyl ester derivatives for percutaneous absorption
Gullick, D.R.; Ingram, M.J.; Pugh, W.J.; Cox, P.A.; Gard, P.; Smart, J.D.; Moss, G.P. (2009)To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare ... -
Pharmacy student perceptions of educational media tools
Ingram, M.J.; Sagoe, L.A.; Sosabowski, M.H.; Moss, G.P.; Long, A.J. (2007) -
A potential anti-implantation and spermicidal strategy : Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity
Ingram, M.J.; Zeller, E.; Moss, G.P.; Hall, C.E. (2006)We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to ... -
Predicting drug absorption rates through human skin
Sun, Yi.; Lam, L.Y.; Moss, G.P.; Prapopoulou, M.; Adams, R.G.; Davey, N.; Gray, David; Brown, Marc (Institute of Electrical and Electronics Engineers (IEEE), 2010)Predicting the rate at which a substance will pass through human skin and into the bloodstream is a problem of current interest. We use Gaussian Process modeling to train a set of predictors using every combination of six ... -
A Raman spectroscopic investigation of bioadhesive tetracaine local anaesthetic formulations
Dennis, A.C.; McGarvey, J.J.; Woolfson, A.D.; McCafferty, D.F.; Moss, G.P. (2004)