Browsing by Author "Murdock, P."

Now showing items 1-4 of 4

    • Characterization of the human HCN1 subunit and its inhibition by capsazepine 

      Gill, C.H.; Bates, S.A.; Owen, D.; Larkman, P.; Cairns, W.; Yusuf, S.; Murdock, P.; Strijbos, P.; Powell, A.; Benham, C.D.; Davies, C.H. (2004)
      The human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. ...

    • Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1 

      Hayes, P.; Meadows, H.J.; Gunthorpe, M.J.; Harries, M.; Duckworth, M.; Cairns, W.; Harrison, D. C.; Ellington, K.; Prinjha, R.; Barton, A.; Medhurst, A.D.; Smith, G.D.; Topp, S.; Sanger, G.; Jenkins, O.; Benham, C.D.; Gloger, I.; Clarke, C. E.; Murdock, P.; Terrett, J.; Randall, A. D.; Gloger, I. S.; Davis, J. B. (2000-11-01)
      Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we ...

    • Cloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channel 

      Meadows, H.J.; Benham, C.D.; Cairns, W.; Gloger, I.; Jennings, C.; Medhurst, A.D.; Murdock, P.; Chapman, C.G. (2000)
      We have cloned human TREK-1, one of the newly emerging mammalian family of 2-P domain potassium channels. The channel has 411 amino acids with a 41-amino-acid extension at the C-terminus when compared with the cloned mouse ...

    • Tissue distribution profiles of the human TRPM cation channel family 

      Fonfria, E.; Murdock, P.; Cusdin, F.S.; Benham, C.D.; Kelsell, R.E.; McNulty, S. (2006)