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Browsing by Author "Pharmaceutical Analysis and Product Characterisation"
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3D Characterisation of Dry Powder Inhaler Formulations: Developing X-ray Micro Computed Tomography Approaches
Gajjar, P; Styliari, I D; Nguyen, T T H; Carr, J; Chen, X; Elliott, J A; Hammond, R B; Burnett, T L; Roberts, K; Withers, P J; Murnane, D (2020-06)Carrier-based dry powder inhaler (DPI) formulations need to be accurately characterised for their particle size distributions, surface roughnesses, fines contents and flow properties. Understanding the micro-structure of ... -
Acceptability in the Older Population: The Importance of an Appropriate Tablet Size
Vallet, Thibault; Michelon , Hugues; Orlu, Mine; Jani, Yogini Hariprasad; Leglise , Patrick; Laribe-Caget , Sandra; Piccoli, Matthieu; Le Fur , Aurélie; Liu, Fang; Ruiz , Fabrice; Boudy , Vincent (2020-08-08)Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia ... -
Acceptability of oral solid medicines in older adults with and without dysphagia : a nested pilot validation questionnaire based observational study
Liu, Fang; Ghaffur, Ambreen; Bains, Jackreet; Hamdy, Shaheen (2016-10-30)Older patients (aged 65 years and over) are the major consumers of medicines and many barriers affect their ability in taking medicines orally, especially swallowing difficulties. Moreover, the characteristics of differing ... -
Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
Advances in oral transmucosal drug delivery
Patel, Viralkumar F.; Liu, Fang; Brown, Marc (2011-07-30)The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ... -
Age-mediated changes in the gastrointestinal tract
Merchant, Hamid; Liu, Fang; Orlu Gul, Mine; Basit, Abdul (2016-10-30)Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of ... -
Apparatus, buffer and method for pH control
School of Life and Medical Sciences; Department of Clinical and Pharmaceutical Sciences; Centre for Research into Topical Drug Delivery and Toxicology; Pharmaceutics; Pharmaceutical Analysis and Product Characterisation; Bioadhesive Drug Delivery Group; Liu, Fang; Curl, Andrew; Fitzgerald , Dean (2019-04) -
The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
Moss, Gary; Sun, Yi; Wilkinson, Simon C.; Davey, N.; Adams, Roderick; Martin, Gary P.; Prapopopolou, M.; Brown, Marc (2011-11)Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ... -
The application of feature selection to the development of Gaussian process models for percutaneous absorption.
Lam, L.T.; Sun, Yi; Davey, N.; Adams, Roderick; Prapopoulou, M.; Brown, Marc; Moss, Gary (2010)Objectives: The aim was to employ Gaussian processes to assess mathematically the nature of a skin permeability dataset and to employ these methods, particularly feature selection, to determine the key physicochemical ... -
Application of sebomics for the analysis of residual skin surface components to detect potential biomarkers of type-1 diabetes mellitus
Shetage, Satyajit S; Traynor, Matthew J; Brown, Marc B; Galliford, Thomas M; Chilcott, Robert P (2017-08-21)Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate and ... -
Assessment of a cyclone-type spacer device for use in dry powder inhalation
Parisini, I.; Cheng, S. J.; Symons, D. D.; Brown, Marc; Kostrzewski, A.; Murnane, D. (2013-08)Dry powder inhalers (DPIs) are used widely in asthma and chronic obstructive pulmonary disease therapies. However, the lung deposition from DPIs is highly variable and patients with poor lung function can struggle to achieve ... -
Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development
Merchant, Hamid A.; McConnell, Emma L.; Liu, Fang; Ramaswamy, Chandrasekaran; Kulkarni, Rucha P.; Basit, Abdul W.; Murdan, Sudaxshina (2011-01-18)Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem ... -
Assessment of swallowability and palatability of oral dosage forms in children : Report from an M-CERSI pediatric formulation workshop
Ternik, Robert; Liu, Fang; Bartlett, Jeremy A; Khong, Yuet Mei; Thiam Tan, David Cheng; Dixit, Trupti; Wang, Siri; Galella, Elizabeth A; Gao, Zhihui; Klein, Sandra (2018-02-05)The acceptability of pediatric pharmaceutical products to patients and their caregivers can have a profound impact on the resulting therapeutic outcome. However, existing methodology and approaches used for acceptability ... -
ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes
McAuley, W. J.; Lad, M. D.; Mader, K. T.; Santos, P.; Tetteh, J.; Kazarian, S. G.; Hadgraft, J.; Lane, M. E. (2010-02)The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. ... -
Branched Copolymer Surfactants as Versatile Templates for Responsive Emulsifiers with Bespoke Temperature‐Triggered Emulsion‐Breaking or Gelation
Rajbanshi, Abhishek; Alves da Silva, Marcelo; Haslett, Niamh; Cranwell, Philippa; Cunningham, Neil; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cecile; Cook, Michael (2023-10-27)It has been found that the thermoresponsive behavior of emulsions stabilized by block copolymer surfactants (BCSs) can induce either gelation or emulsion break‐up with mild temperature changes. A hydrophilic, steric‐stabilizing ... -
Can children swallow tablets? Outcome data from a feasibility study to assess the swallowability and acceptability of different sized placebo tablets in children and young people (Creating Acceptable Tablets - CAT)
Bracken, Louise; McDonough, Emma; Ashleigh, Samantha; Wilson, Fiona; Shakeshaft, Joanne; Ohia, Udeme; Mistry, Punam; Jones, Huw; Kanji, Nazim; Liu, Fang; Peak, Matthew (2020-10-10)Objective Feasibility study to investigate the acceptability of different-sized placebo tablets in children aged 4–12 years. Design and setting Clinical Research Facilities, inpatient wards and outpatient clinics within a ... -
Characterisation of the Interaction of Lactate Dehydrogenase With Tween-20 Using Isothermal Titration Calorimetry, Interfacial Rheometry and Surface Tension Measurements
Mcauley, William J.; Jones, David S.; Kett, Vicky L. (2009-08)In this study the nature of the interaction between Tween-20 and lactate dehydrogenase (LDH) was investigated using isothermal titration calorimetry (ITC). In addition the effects of the protein and surfactant on the ... -
Characterization of latent heat-releasing phase change materials for dermal therapies
Wood, D.G.; Brown, Marc; Jones, S. A.; Murnane, D. (2011-04-28)Phase change materials (PCMs) have been developed as heat storage solutions, particularly for the supply of “green” energy. One interesting use of PCMs is long-term energy storage, in which a phase transition is triggered ... -
Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro
Stewart, C.A.; Turner, Rob B.; Brown, Marc; Traynor, M.J. (Royal Society of Chemistry, 2014-04-14)Any chemical that is applied to the skin has the potential to induce a skin reaction. These reactions are complicated and are difficult to fully replicate in vitro and may exhibit species variations when reproduced in vivo. ... -
Collection and characterisation of residual skin surface components obtained from sebum, sweat and epidermal lipids
Shetage, S.S.; Traynor, M.J.; Brown, Marc; Chilcott, Robert (Royal Society of Chemistry, 2014-04-14)Collection and analysis of skin surface lipids or sebum has been reported in several previous studies where Sebutape™, polyurethane foam, cigarette paper and organic solvents were used to acquire samples, analysis of which ...