Browsing by Author "Qi, Sheng"

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Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery : kinetic modelling and practical implications

Qi, Sheng; Belton, Peter; McAuley, William James; Codoni, Dorothy; Darji, Neerav (2013-04)

Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, ...
Physical stabilization of low-molecular-weight amorphous drugs in the solid state : a material science approach

Qi, Sheng; McAuley, William J.; Yang, Ziyi; Tipduangta, Pratchaya (2014-07)

Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much ...
Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films

Ng, Yuen Chuen; Yang, Ziyi; McAuley, William James; Qi, Sheng (2013-08)

In this study, the stabilization effects of three polymers on four model drugs (felodipine, fenofibrate, carbamazepine, and celecoxib) under saturated humidity were investigated. Three different types of thin films (solid ...