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Browsing by Author "Reddy, Tummala Rama Krishna"
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Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin A2
Li, Chan; Reddy, Tummala Rama Krishna; Fischer, Peter M.; Dekker, Lodewijk V. (2010)Protein–protein interactions are increasingly of interest as targets in small-molecule drug discovery. The interaction between the Ca2+- and phospholipid-binding protein Annexin A2 and its binding partner S100A10 has been ... -
Design, Synthesis and SAR Exploration of Tri-substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction
Reddy, Tummala Rama Krishna; Li, Chan; Guo, Xiaoxia; Fischer, Peter; Dekker, Lodewijk (2014-10-01)Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain ... -
Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
Anagani, Bhavani; Singh, Jagbir; Bassin, Jatinder; Besra, Gurdyal; Benham, Christopher; Reddy, Tummala Rama Krishna; Cox, Jonathan; Goyal, Madhu (2020-05-18)Objectives: The search for new TB drugs has become one of the great challenges for modern medicinal chemistry. An improvement in the outcomes of TB chemotherapy can be achieved by the development of new, shorter, cheap, ... -
Library Design, Synthesis and Screening : Pyridine Dicarbonitriles as Potential Prion Disease Therapeutics
Reddy, Tummala Rama Krishna; Mutter, Roger; Heal, William; Guo, Kai; Gillet, Valerie J.; Pratt , Steven; Chen, Beining (2006)Transmissible spongiform encephalopathies (TSEs) or prion diseases are a family of invariably fatal neurodegenerative disorders, and there are no effective therapeutics currently available. In this paper, we report on the ... -
Mechanistic studies leading to a new procedure for rapid microwave assisted generation of pyridine-3,5-dicarbonitrile libraries
Guo, Kai; Thompson, Mark J.; Reddy, Tummala Rama Krishna; Mutter , Roger; Chen, Beining (2007-06-11)Mechanistic investigations into the multi-component synthesis of pyridine-3,5-dicarbonitriles have established a defined reaction pathway, particularly clarifying the role of aerobic oxidation in conversion of the intermediate ... -
Patent: Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for the treatment of cancer and other diseases
Department of Pharmacy; School of Life and Medical Sciences; Health & Human Sciences Research Institute; Medicinal and Analytical Chemistry; Reddy, Tummala Rama Krishna; Li, Chan; Fischer, Peter M.; Dekker, Lodewijk V. (2011-08-04)This invention relates to compounds that are inhibitors of S100 protein binding interactions, such as, for example, the annexin A2-S100A10 protein binding interaction. More specifically, this invention concerns certain ... -
Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction : Potential anti-angiogenesis therapeutics
Reddy, Tummala Rama Krishna; Li, Chan; Guo, Xiaoxia; Fischer, Peter; Dekker, Lodewijk (2010)