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Browsing by Author "Vilar, Enric"
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An Association between Residual Renal Function and Depression Symptoms in Haemodialysis Patients
Chilcot, J.; Wellsted, D.; Vilar, Enric; Farrington, Ken (2009)Background: The loss of residual renal function (RRF) and subsequent urine volume among haemodialysis (HD) patients may influence affect. Although RRF has been associated with improved patient outcome, its relationship ... -
Attitudes in Patients with Autosomal Dominant Polycystic Kidney Disease Toward Prenatal Diagnosis and Preimplantation Genetic Diagnosis
Swift, Oscar; Vilar, Enric; Rahman, Belinda; Side, Lucy; Gale, Daniel P (2016-12-01)AIMS: No recommendations currently exist regarding implementation of both prenatal diagnosis and preimplantation genetic diagnosis (PGD) for autosomal dominant polycystic kidney disease (ADPKD). This study evaluated attitudes ... -
Beta-glucans in advanced CKD : role in endotoxaemia and inflammation
Wong, Jonathan; Zhang, Yonglong; Swift, Oscar; Finkelman, Malcolm; Patidar, Ashish; Ramanarayanan, Sivaramakrishnan; Vilar, Enric; Farrington, Ken (2020-04-06)BACKGROUND/AIMS: (1-3)-β-D glucans (BG) are cellular components of yeasts and fungi. Elevated blood levels may be an adjunct in diagnosing invasive fungal infection, though can be high in dialysis patients without fungaemia. ... -
A comparative study of blood endotoxin detection in haemodialysis patients
Wong, Jonathan; Davies, Nathan; Jeraj, Hasan; Vilar, Enric; Viljoen, Adie; Farrington, Kenneth (2016-07-30)BACKGROUND: Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endotoxin ... -
Creatinine reduction ratio : a useful marker to identify medium and high-risk renal transplants
Vilar, Enric; Varagunam, Mira; Yaqoob, Muhammad M; Raftery, Martin; Thuraisingham, Raj (2010-01-15)INTRODUCTION: Delayed graft function (DGF) has a major impact on long-term renal transplant survival. However, it is a diagnosis made retrospectively with little opportunity to modify treatment protocols. A classification ... -
Disease-specific predictive formulas for energy expenditure in the dialysis population
Vilar, Enric; Machado, Ashwini; Garrett, Andrew; Kozarski, Robert; Wellsted, D.; Farrington, Ken (2014-04-28)OBJECTIVE: Metabolic rate is poorly understood in advanced kidney disease because direct measurement is expensive and time-consuming. Predictive equations for resting energy expenditure (REE) are needed based on simple ... -
Emerging importance of residual renal function in end-stage renal failure
Vilar, Enric; Farrington, Ken (2011-10-18)Residual renal function (RRF) is well recognized as an important marker of outcomes in peritoneal dialysis (PD), and contributes vitally to solute clearance. Recently, its importance in hemodialysis (HD) has emerged with ... -
Endotoxemia in end-stage kidney disease
Wong, Jonathan; Vilar, Enric; Farrington, Kenneth (2015-01-08)Chronic unexplained inflammation remains a prevalent and clinically significant problem for patients with end-stage kidney disease (ESKD), especially in the dialysis population. The causes of persistent inflammation are ... -
Endotoxin detection in end-stage kidney disease
Wong, Jonathan; Jeraj, Hassan; Vilar, Enric; Viljoen, Adie; Farrington, Kenneth (2015-01-01)Aims: Endotoxin detection assays are not validated for use in end-stage kidney disease (ESKD). We investigated the accuracy and precision of the kinetic turbidimetric Limulus amoebocyte lysate (LAL) assay to detect endotoxin ... -
Energy expenditure estimates in chronic kidney disease using a novel physical activity questionnaire
Sridharan, Sivakumar; Vilar, Enric; Ramanarayanan, Sivaramakrishnan; Davenport, Andrew; Farrington, Ken (2021-01-08)BACKGROUND: Physical activity (PA) levels are low in patients with advanced chronic kidney disease (CKD), and associate with increased morbidity and mortality. Reliable tools to assess PA in CKD are scarce. We aimed to ... -
Energy metabolism, body composition, and urea generation rate in hemodialysis patients
Sridharan, Sivakumar; Vilar, Enric; Berdeprado, Jocelyn; Farrington, Ken (2013-10-01)Hemodialysis (HD) adequacy is currently assessed using normalized urea clearance (Kt/V), although scaling based on Watson volume (V) may disadvantage women and men with low body weight. Alternative scaling factors such as ... -
Impact of incremental initiation of haemodialysis on mortality: a systematic review and meta-analysis
Caton, Emma; Sharma, Shivani; Vilar, Enric; Farrington, Kenneth (2023-02-28)Background Incremental haemodialysis initiation entails lower sessional duration and/or frequency than the standard 4 h thrice-weekly approach. Dialysis dose is increased as residual kidney function (RKF) declines. This ... -
Impact of incremental versus conventional initiation of haemodialysis on residual kidney function : study protocol for a multicentre feasibility randomised controlled trial
Kaja Kamal, Raja Mohammed; Farrington, Ken; Wellsted, David; Sridharan, Sivakumar; Alchi, Bassam; Burton, James; Davenport, Andrew; Vilar, Enric (2020-08-13)INTRODUCTION: Preserving residual kidney function (RKF) may be beneficial to patients on haemodialysis (HD) and it has been proposed that commencing dialysis incrementally rather than three times a week may preserve RKF. ... -
Incremental haemodialysis
Wong, Jonathan; Vilar, Enric; Davenport, Andrew; Farrington, Kenneth (2015-06-01)Thrice-weekly haemodialysis schedules have become the standard default haemodialysis prescription worldwide. Whereas the measurement of residual renal function is accepted practice for peritoneal dialysis patients and the ... -
Indexing Dialysis Dose for Gender, Body size and Physical Activity: Impact on Survival
Sridharan, Sivakumar; Wellsted, David; Vilar, Enric; Davenport, Andrew; Ashman, Neil; K Almond, Michael; Banerjee, Anindya; Roberts, Justin; Farrington, Kenneth (2018-07-25)Background Current practice basing dialysis dose on urea distribution volume (V), has been questioned. We explored the impact on survival of scaling dialysis dose (Kt) to parameters reflective of metabolic activity. ... -
Initiating haemodialysis twice-weekly as part of an incremental programme may protect residual kidney function
Kaja Kamal, Raja Mohammed; Farrington, Ken; Busby, Amanda D; Wellsted, David; Chandna, Humza; Mawer, Laura J; Sridharan, Sivakumar; Vilar, Enric (2018-10-23)Background: Initiating twice-weekly haemodialysis (2×HD) in patients who retain significant residual kidney function (RKF) may have benefits. We aimed to determine differences between patients initiated on twice- and ... -
Is Endotoxemia in Stable Hemodialysis Patients an Artefact? : Limitations of the Limulus Amebocyte Lysate Assay and Role of (1→3)-β-D Glucan
Wong, Jonathan; Zhang, Yonglong; Patidar, Ashish; Vilar, Enric; Finkelman, Malcolm; Farrington, Kenneth (2016-10-20)BACKGROUND: Elevated blood endotoxin levels are frequently reported in the dialysis population and are strongly linked with inflammation, a major predictor of mortality. Virtually all studies have employed the Limulus ... -
Long-Term Outcomes in Online Hemodiafiltration and High-Flux Hemodialysis : A Comparative Analysis
Vilar, Enric; Fry, A.C.; Wellsted, D.; Tattersall, J.E.; Greenwood, R.N.; Farrington, Ken (2009)Background and objectives: Theoretical advantages exist of online hemodiafiltration (HDF) over high-flux hemodialysis (HD), but outcome data are scarce. Our objective was to compare outcomes between these modalities. Design, ... -
Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection
Wong, Jonathan; Kaja Kamal, Raja Mohammed; Vilar, Enric; Farrington, Kenneth (2017-01-02)Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and ... -
A multicenter feasibility randomized controlled trial to assess the impact of incremental versus conventional initiation of hemodialysis on residual kidney function
Vilar, Enric; Kaja Kamal, Raja M; Fotheringham, James; Busby, Amanda; Berdeprado, Jocelyn; Kislowska, Ewa; Wellsted, David; Alchi, Bassam; Burton, James O; Davenport, Andrew; Farrington, Ken (2021-08-19)Twice-weekly hemodialysis, as part of incremental initiation, has reported benefits including preservation of residual kidney function (RKF). To explore this, we initiated a randomized controlled feasibility trial examining ...