- UHRA Home
- University of Hertfordshire
- Browsing University of Hertfordshire by Author
Browsing University of Hertfordshire by Author "Hadgraft, J."
Now showing items 1-7 of 7
-
ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes
McAuley, W. J.; Lad, M. D.; Mader, K. T.; Santos, P.; Tetteh, J.; Kazarian, S. G.; Hadgraft, J.; Lane, M. E. (2010-02)The uptake and diffusion of solvents across polymer membranes is important in controlled drug delivery, effects on drug uptake into, for example, infusion bags and containers, as well as transport across. protective clothing. ... -
Determination of the diffusion coefficient of cyanophenol in carbosil membrane using ATR-FTIR spectroscopy
McAuley, L.; Santos, P.; Lane, M. E.; Hadgraft, J.; McAuley, William (2006-09)Model membranes are often used in place of human skin when evaluating dermal drug delivery systems. This is because they offer several advantages compared with human epidermis including their ready availability, uniformity ... -
Inter- and intralaboratory variation of in vitro diffusion cell measurements : An international multicenter study using quasi-standardized methods and materials
Chilcott, Robert; Barai, N; Beezer, A. E.; Brain, S I; Brown, Marc; Bunge, A L; Burgess, S E; Cross, S; Dalton, C H; Dias, M; Farinha, A; Finnin, B C; Gallagher, S J; Green, D M; Gunt, H; Gwyther, R L; Heard, C.M.; Jarvis, C A; Kamiyama, F; Kasting, G B; Ley, E E; Lim, S T; Mcnaughton, G S; Morris, A; Nazemi, M H; Pellett, M A; Du Plessis, J; Quan, Y S; Raghavan, S L; Roberts, M.; Romonchuk, W; Roper, C S; Schenk, D; Simonsen, L; Simpson, A; Traversa, B D; Trottet, L; Watkinson, A; Williams, F.M.; Wilkinson, S C; Yamamoto, A; Hadgraft, J. (2005-03)In vitro measurements of skin absorption are an increasingly important aspect of regulatory studies, product support claims, and formulation screening. However, such measurements are significantly affected by skin variability. ... -
Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
Mader, K. T.; Tetteh, J.; McAuley, W. J.; Lane, M. E.; Hadgraft, J.; Andanson, J. M.; Kazarian, S. G. (2010-10)ATR-FTIR spectroscopic imaging permeation experiments of a model formulation across stratum corneum (SC) were conducted to acquire further understanding of the mechanism of drug permeation. Quantitative iterative target ... -
Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis
Tetteh, J.; Mader, K. T.; Andanson, J. M.; McAuley, W. J.; Lane, M. E.; Hadgraft, J.; Kazarian, S. G.; Mitchell, J. C. (2009-05-29)In the context of trans-dermal drug delivery it is very important to have mechanistic insight into the barrier function of the skin's stratum corneum and the diffusion mechanisms of topically applied drugs. Currently ... -
Opto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivo
Xiao, P.; Zheng, X.; Imhof, R. E.; Hirata, K.; McAuley, W. J.; Mateus, R.; Hadgraft, J.; Lane, M. E. (2011-03-15)This work describes the first application of Opto-Thermal Transient Emission Radiometry (OTTER), an infrared remote sensing technique, to probe the extent to which solvents permeate the human nail in vivo. Decanol, glycerol ... -
Thermodynamic considerations of solvent/enhancer uptake into a model membrane
McAuley, W. J.; Oliveira, G.; Mohammed, D.; Beezer, A. E.; Hadgraft, J.; Lane, M. E. (2010-08-30)The aim of this study was to conduct a thermodynamic analysts of the uptake of solvents into a model membrane as a precursor to skin transport studies. The investigation was designed so that the methodology may be applied ...