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Browsing University of Hertfordshire by Author "Inal, Jameel"
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Animal Models of Human Disease
Lange, Sigrun; Inal, Jameel (2023-10-31)The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled ... -
Cancer cell expulsion of anticancer drugs through shedding of microvesicles: association with drug resistance and tumour survival
Jorfi, Samireh; Inal, Jameel (2012-09-13)Microvesicles (MVs) are small (0.1-≤1 µm in diameter) heterogeneous vesicles released from cells constitutively or upon activation, that mediate intercellular communication. Multi-drug resistance (MDR) has been defined as ... -
Cannabidiol (CBD) is a novel inhibitor for exosome and microvesicle (EMV) release in cancer
Kosgodage, Uchini S; Mould, Rhys; Henley, Aine; Nunn, alistair; Guy, Geoffrey; Thomas, E. Louise; Inal, Jameel; Bell, Jimmy; Lange, Sigrun (2018-08-13)Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with ... -
Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
Kosgodage, Uchini S; Uysal-Onganer, Pinar; MacLatchy, Amy; Mould, Rhys; Nunn, Alistair; Guy, Geoffrey; Kraev, Igor; Chatterton, Nicholas; Inal, Jameel; Thomas, E. Louise; Bell, Jimmy; Lange, Sigrun (2019-03-01)Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key-mediators for cellular communication through transfer ... -
Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles
Kosgodage, Uchini S; Matewele, Paul; Awamaria, Brigitte; Kraev, Igor; Warde, Purva; Mastroianni, Giulia; Nunn, alistair; Guy, Geoffrey; Bell, Jimmy; Inal, Jameel; Lange, Sigrun (2019-09-10)Membrane vesicles (MVs) released from bacteria participate in cell communication and host-pathogen interactions. Roles for MVs in antibiotic resistance are gaining increased attention and in this study we investigated if ... -
Characterisation of microvesicles released from cells constitutively and upon stimulation
Stratton, Dan; Inal, Jameel (2012-09-13)Constitutively released microvesicles (cMVs) are released as a part of normal cell physiology and this is summarised in Fig. 1 (1). However stimulated microvesicles (sMVs) are released as a result of a number of possible ... -
Communication is key : Extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants
Stotz, Henrik U; Brotherton, Dominik; Inal, Jameel (2021-08-27)Extracellular vesicles (EVs) are now understood to be ubiquitous mediators of cellular communication. In this review, we suggest that EVs have evolved into a highly regulated system of communication with complex functions ... -
Complement C2
Dinasarapu, Ashok Dinasarapu; Chandrasekhar, Anjana; Inal, Jameel; Subramaniam, Shankar (2013-12-10)Complement C2 is a single chain serum glycoprotein (110 kDa), which serves as the catalytic subunit of C3 and C5 convertases in the classical and lectin pathways. During complement activation, C2 is cleaved by classical ... -
Coxsackie virus entry and spread in HeLa cells is aided by microvesicle release
Jorfi, Samireh; Inal, Jameel (2012-09-13)Microvesicles(MVs) released from plasma membrane expressing surface phosphatidylserine and ranging from 0.2-≤1 m in diameter are reported to carry various membrane proteins, lipids and cytoplasmic components characteristic ... -
Developing microfluidic devices and techniques for isolation and detection of Extracellular Vesicles (EVs)
Lekkala, Himayasri; Dimov, Nikolay; Johnston, Ian; Inal, Jameel (2020-10-09)The purpose of this research is to develop microfluidic devices and systems for the effective isolation of bacterial Extracellular vesicles (EVs) by applying Tangential Flow Filtration (TFF) operation. The purification and ... -
Human skeletal muscle derived microvesicles induce apoptosis in highly metastatic prostate cancer cells
Inal, Jameel; Kholia, Sharad (2012-09-13)The human skeletal muscle is a highly vascularised tissue that contributes approximately 40% of the total body mass. These two factors make it a prime target for secondary cancer metastases. Surprisingly, malignant cancers ... -
An induced population of Trypanosoma cruzi epimastigotes more resistant to complement lysis promotes a phenotype with greater differentiation, invasiveness, and release of extracellular vesicles
Rossi , Izadora Volpato; Nunes, Maria Alice Ferreira; Sabatke, Bruna; Ribas , Hennrique Taborda; Winnischofer , Sheila Maria Brochado; Ramos, Augusto Savio Peixoto; Ramirez, Marcel Ivan; Inal, Jameel (2022-12-14)Introduction: Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi, which uses blood-feeding triatomine bugs as a vector to finally infect mammalian hosts. Upon entering the host, the parasite needs ... -
Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo
Jorfi, Samireh; Ansa-Addo, Ephraim A.; Kholia, Sharad; Stratton, Dan; Valley, Shaunelle; Lange, Sigrun; Inal, Jameel (2015-08-25)Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could ... -
Isolation of microvesicles and exosomes by microfiltration and estimation of normal reference range in blood plasma.
Grant, Ryan; Inal, Jameel (2012-09-13)Current protocols for the isolation of microvesicles (MVs) and exosomes, which in the main focus on differential centrifugation, vary considerably (1). In an attempt to set a new standard, we describe a filtration protocol ... -
Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance
Stratton, Dan; Lange, Sigrun; Kholia, Sharad; Jorfi, Samireh; Antwi-Baffour, Samuel; Inal, Jameel (2014-10-24)Using a Quartz Crystal Microbalance with dissipation monitoring, QCM-D (label-free system) measuring changes in resonant frequency (Δf) that equate to mass deposited on a sensor, we showed the attachment, over a 60 min ... -
Membrane vesicles of Clostridioides difficile and other Clostridial species
Goh, Shan; Inal, Jameel (Springer Nature, 2024-01-05)Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. Membrane vesicles ... -
Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury
Sisa, Claudia; Kholia, Sharad; Naylor, Jordan; Herrera Sanchez, Maria Beatriz; Bruno, Stefania; Deregibus, Maria Chaiara; Camussi, Giovanni; Inal, Jameel; Lange, Sigrun; Hristova, Mariya (2019-03-19)Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need ... -
Microvesicles and epithelial mesenchymal transition in the development of cancer
Inal, Jameel (2012-09-13)Microvesicles released by tumour cell lines are thought to play an important role in both extracellular matrix (ECM) invasion and evasion of the immune system. We have examined the role of MVs derived from a T cell line ... -
Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9
Stratton, Dan; Moore, Colin; Antwi-Baffour, Samuel; Lange, Sigrun; Inal, Jameel (2015-05-08)We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism and sMVs, ... -
Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro
Evans-Osses, Ingrid; Mojoli, Andres; Monguió-Tortajada, Marta; Marcilla, Antonio; Aran, Veronica; Amorim, Maria; Inal, Jameel; Borràs, Francesc E; Ramirez, Marcel I (2017-03-31)Giardia intestinalis (G.I), is an anaerobic protozoan and the aetiological agent of giardiasis, a diarrhoea present worldwide and associated with poverty. G.I has a simple life cycle alternating between cyst and trophozoite. ...