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Browsing University of Hertfordshire by Author "Qi, Sheng"
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Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles
Codoni, Doroty; Cowan, Jonathan; Bradley, Jenna; McAuley, William J; O'Connell, Maria A; Qi, Sheng (2015-12-30)Disc-shaped nanoparticles with high aspect ratios have been reported to show preferential cellular uptake in vitro by mammalian cells. However, engineering and producing such disc-shaped nanoparticles are often complex. ... -
Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery : kinetic modelling and practical implications
Qi, Sheng; Belton, Peter; McAuley, William James; Codoni, Dorothy; Darji, Neerav (2013-04)Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, ... -
Physical stabilization of low-molecular-weight amorphous drugs in the solid state : a material science approach
Qi, Sheng; McAuley, William J.; Yang, Ziyi; Tipduangta, Pratchaya (2014-07)Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much ... -
Rationalising polymer selection for supersaturated film forming systems produced by an aerosol spray for the transdermal delivery of methylphenidate
Edwards, Andrew; Qi, Sheng; Liu, Fang; Brown, Marc; McAuley, William (2017-05-01)Film forming systems offer a number of advantages for topical and transdermal drug delivery, in particular enabling production of a supersaturated state which can greatly improve drug absorption and bioavailability. However ... -
Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films
Ng, Yuen Chuen; Yang, Ziyi; McAuley, William James; Qi, Sheng (2013-08)In this study, the stabilization effects of three polymers on four model drugs (felodipine, fenofibrate, carbamazepine, and celecoxib) under saturated humidity were investigated. Three different types of thin films (solid ... -
The use of polymer blends to improve stability and performance of electrospun solid dispersions: The role of miscibility and phase separation
Tipduangta, Pratchaya; Belton, Peter; McAuley, William; Qi, Sheng (2021-06-01)Solid dispersion-based nanofiber formulations of poorly soluble drugs prepared by electrospinning (ES) with a water-soluble polymer, can offer significant improvements in drug dissolution for oral drug administration. ...