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Browsing University of Hertfordshire by Author "Saxton, Katie"
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Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model
Baines, Simon D.; O'Connor, Rachel; Saxton, Katie; Freeman, Jane; Wilcox, M. H. (2009)Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with ... -
Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model
Baines, Simon D.; O'Connor, Rachael; Saxton, Katie; Freeman, Jane; Wilcox, Mark H. (2008)To compare the efficacy of oritavancin and vancomycin in the treatment of Clostridium difficile infection (CDI) using an in vitro human gut model. -
Effect of metronidazole on growth and toxin production by epidemic Clostridium difficile PCR ribotypes 001 and 027 in a human gut model
Freeman, Jane; Baines, Simon D.; Saxton, Katie; Wilcox, Mark H. (2007)We compared the behaviour of Clostridium difficile PCR ribotypes 001 and 027 in a human gut model, and compared the responses to metronidazole exposure. -
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model
Saxton, Katie; Baines, Simon D.; Freeman, Jane; O'Connor, Rachael; Wilcox, M. H. (2009)The incidence of Clostridium difficile infection is increasing, with reports implicating fluoroquinolone use. A three-stage chemostat gut model was used to study the effects of three fluoroquinolones (ciprofloxacin, ... -
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains
Fawley, Warren N; Underwood, Sarah; Freeman, Jane; Baines, Simon D.; Saxton, Katie; Stephenson, Keith; Owens, Robert C.; Wilcox, M. H. (2007)To compare the effects of hospital cleaning agents and germicides on the survival of epidemic Clostridium difficile strains. -
Mecillinam : a low-risk antimicrobial agent for induction of Clostridium difficile infection in an in vitro human gut model
Baines, Simon D.; O'Connor, Rachael; Huscroft, Grace; Saxton, Katie; Freeman, Jane; Wilcox, Mark H (2009) -
Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model
Baines, Simon D.; Saxton, Katie; Freeman, Jane; Wilcox, Mark H. (2006)Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new ...