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Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1
(2011-11-16)
NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane ...
The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus
(2011-11)
Some isolates of the opportunistic human pathogenic fungus Aspergillus fumigatus are known to be infected with mycoviruses. The dsRNA genomes of two of these mycoviruses, which include a chrysovirus and a partitivirus, ...
Receptive field optimisation and supervision of a fuzzy spiking neural network
(2011-04)
This paper presents a supervised training algorithm that implements fuzzy reasoning on a spiking neural network. Neuron selectivity is facilitated using receptive fields that enable individual neurons to be responsive to ...
Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development
(2011-01-18)
Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem ...
Sustained performance by red and white muscle fibres from the dogfish Scyliorhinus canicula
(2010-06-01)
The mechanical performance of red and white muscle fibres from dogfish was compared during a long series of contractions with sinusoidal movement or under isometric conditions at 12 degrees C (normal in vivo temperature). ...
Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol
(2010-06)
The olive oil polyphenol, hydroxytyrosol (HT), is believed to be capable of exerting protection against oxidative kidney injury. In this study we have investigated the ability of HT and its O-methylated metabolite, ...
Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
(2010-04)
The degeneration of dopaminergic neurons in the substantia nigra has been linked to the formation of the endogenous neurotoxin 5-S-cysteinyl-dopamine. Sulforaphane (SFN), an isothiocyanate derived from the corresponding ...
Wide-field motion integration in fly VS cells : insights from an inverse approach
(2010)
Fly lobula plate tangential cells are known to perform wide-field motion integration. It is assumed that the shape of these neurons, and in particular the shape of the subclass of VS cells, is responsible for this type of ...
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
(2009-04-01)
Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) ...
Systematic mapping between dendritic function and structure
(2009)
For many classes of neurons, the relationship between computational function and dendritic morphology remains unclear. To gain insights into this relationship, we utilize an inverse approach in which we optimize model ...