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The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076
(1998-08-15)
ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological ...
The processes influencing the distribution of parasitic nematodes among naturally infected lambs
(1998-08)
The impact of mixed, nematode infection upon a group of animals will depend upon the number of nematodes present, how they are distributed among hosts and whether individuals that are heavily parasitized with one species ...
Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep
(1998-08)
Flunixin meglumine (FM, 1.1 mg/kg) and phenylbutazone (PBZ, 4.4 mg/kg) were administered intravenously (i.v.) as a single dose to eight sheep prepared with subcutaneous (s.c.) tissue-cages in which an acute inflammatory ...
Analysis of ribosomal DNA sequences of Polymyxa species and related fungi and the development of genus- and species-specific PCR primers
(1998-08)
A region of about 800 bp of ribosomal DNA has been sequenced in 10 isolates of Polymyxa and one isolate each of Plasmodiophora brassicae and the chytrid Olpidium brassicae. This region consists of about 330 bp at the 3' ...
Speaking of Complexity in Management Theory and Practice
(1998-08)
This paper describes a complexity perspective on organizational life by drawing on three distinctive sources. First, we describe the way different natural scientists talk of their work in simulating complex dynamical ...
Measurement of cyclooxygenase inhibition in vivo : a study of two non-steroidal anti-inflammatory drugs in sheep
(1998-08)
The anti-inflammatory effects of the non-steroidal anti-inflammatory drugs phenylbutazone (PBZ) and flunixin meglumine (FM) and the relationship between the effects and drug concentration in vivo were studied using a ...
Proton capture cross sections of the ruthenium isotopes
(1998-07)
The proton capture cross sections of the stable ruthenium isotopes 96, 98, 99, and 104 have been measured by means of the activation method in the proton energy range between 1.5 and 3 MeV. Thin layers of natural ruthenium ...