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Bupropion perceived as a stimulant by two patients with a previous history of cocaine misuse
(2013-12)
Background and objective. Despite animal studies having shown a generalisation of the bupropion cue to cocaine, this drug has been used in cocaine abuse with mixed results. We here aimed at describing two cases which ...
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
(2013-07-09)
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ...
Assessment of Primary Colorectal Cancer Heterogeneity by Using Whole-Tumor Texture Analysis : Contrast-enhanced CT Texture as a Biomarker of 5-year Survival
(2013)
To determine if computed tomographic (CT) texture features of primary colorectal cancer are related to 5-year overall survival rate
Human skeletal muscle derived microvesicles induce apoptosis in highly metastatic prostate cancer cells
(2012-09-13)
The human skeletal muscle is a highly vascularised tissue that contributes approximately 40% of the total body mass. These two factors make it a prime target for secondary cancer metastases. Surprisingly, malignant cancers ...
Cancer cell expulsion of anticancer drugs through shedding of microvesicles: association with drug resistance and tumour survival
(2012-09-13)
Microvesicles (MVs) are small (0.1-≤1 µm in diameter) heterogeneous vesicles released from cells constitutively or upon activation, that mediate intercellular communication. Multi-drug resistance (MDR) has been defined as ...
Coloured filters enhance the visual perception of social cues in children with autism spectrum disorders
(2012)
Coloured filters have been found to reduce visual distortion of text in children with autism spectrum disorders (ASD). We investigated the effect of the overlays on the "mind in the eye" task in children with ASD and ...
Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses
(2011-06-01)
The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide ...
Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas
(2011-03-10)
Background: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood, though risk factors include human papillomavirus (HPV). Disruption of HER/PTEN/Akt pathway is present in many cancers; however ...
Amplification of a Cytochrome P450 Gene Is Associated with Resistance to Neonicotinoid Insecticides in the Aphid Myzus persicae
(2010-06)
The aphid Myzus persicae is a globally significant crop pest that has evolved high levels of resistance to almost all classes of insecticide. To date, the neonicotinoids, an economically important class of insecticides ...
Metabolism of Butoxyethanol in excised human skin in vitro
(2008)
Glycol ethers are widely used in industrial and household applications because their chemical and physical properties make them versatile solvents, miscible with both water and organic media. Due to the ease with which the ...