Now showing items 51-60 of 7172
Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
The nerve growth factor (NGF) receptor, trkA, the tumour suppressor p53 and the phosphatase SHP-1 are critical in cell proliferation and differentiation. SHP-1 is a trkA phosphatase that dephosphorylates trkA at tyrosines ...
Diversity, Culture and Gender
GALICS II : The [ α/Fe]-mass relation in elliptical galaxies
Aims. We test whether the mass-and σ-[α/Fe] relations in the stellar populations of early-type galaxies can be reproduced by a cosmologically motivated assembly history for spheroids.Methods. We implement a detailed treatment ...
Large-scale analysis of Influenza A virus sequences reveals potential drug-target sites of non-structural proteins
The non-structural protein 1 (NS1) of the influenza A virus and the NS2 protein, which is also known as nuclear export protein, play important roles in the infectious life cycle of the virus. The objective of this study ...
In this progress report we review recent work which has investigated the process of glaciohydraulic supercooling and its significance for a range of glaciological and geological phenomena. Since our last report (Knight and ...
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ...
Observer Variation in Interpreting 18F-FDG PET/CT Findings for Lymphoma Staging
Many studies demonstrate a high accuracy for PET in staging lymphoma, but few assess observer variation. This study quantified agreement for staging lymphoma with PET/CT. Methods: The PET/CT images of 100 patients with ...
High-accuracy U-233(n, f) cross-section measurement at the white-neutron source n_TOF from near-thermal to 1 MeV neutron energy
The U-233(n, f) cross section has been measured at the white neutron source n_TOF in a wide energy range with a dedicated fission ionization chamber. We report here the results from similar to 30 meV to 1 MeV neutron energy. ...
An AzTEC 1.1 mm survey of the GOODS-N field - II : Multiwavelength identifications and redshift distribution
We present results from a multiwavelength study of 29 sources (false detection probabilities