Browsing Research publications by Author "Pharmacology and Clinical Science Research"
Now showing items 1-20 of 106
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2,3-Butanedione monoxime increases speed of relaxation in single muscle fibres of frog
Sun, Y-B.; Lou, Fang; Edman, K.A.P. (2001-05)The effects of 2,3-butanedione monoxime (BDM) on intracellular Ca2+ transient and cross-bridge function were studied in frog single fibres from the anterior tibialis muscle of Rana temporaria (sarcomere length, 2.2 microm; ... -
Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway
Deng, L.; Hu, S.; Baydoun, A. R.; Chen, J.; Chen, X.; Cong, X. (2009)Background and Objectives: Mesenchymal stem cells (MSC) are multipotent progenitor cells that are have found use in regenerative medicine. We have previously observed that aspirin, a widely used anti-inflammatory drug, ... -
Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation : implications for a clinical test
Kirkby, Nick; Chan, M.V.; Lundberg, M.H.; MacKenzie, Louise; Leadbeater, Phillip D.M.; Milne, Ginger L.; Potter, Claire M.; Al-Yamani, Malak; Adeyemi, Oladipupo; Warner, Tim D.; Mitchell, Jane A. (2013-10)Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin ... -
An association between depressive symptoms and survival in incident dialysis patients
Chilcot, Joseph; Davenport, Andrew; Wellsted, D.; Firth, John; Farrington, Ken (2011)Depression in end-stage renal disease patients is detrimental to quality of life, and is also associated with adverse clinical outcomes. The aim of this study was to examine whether depression symptoms in 'incident dialysis' ... -
Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle
Sun, Y-B.; Lou, Fang; Irving, M. (2009)Each heartbeat is triggered by a pulse of intracellular calcium ions which bind to troponin on the actin-containing thin filaments of heart muscle cells, initiating a change in filament structure that allows myosin to bind ... -
Cell Culture Techniques
Baydoun, A. R.; Wilson, Keith; Walker, John; Health & Human Sciences Research Institute; School of Life and Medical Sciences; Department of Human and Environmental Sciences; Pharmacology and Clinical Science Research; Cardiovascular Pathologies; Diabetic neuropathies; Biochemistry and Bioinformatics (Cambridge University Press, 2010-03)This best-selling undergraduate textbook provides an introduction to key experimental techniques from across the biosciences. It uniquely integrates the theories and practices that drive the fields of biology and medicine, ... -
Changes in force and stiffness induced by fatigue and intracellular acidification in frog muscle fibres
Edman, K.A.P.; Lou, Fang (1990-05)1. Changes in force and stiffness were recorded simultaneously during 1 s isometric (fixed ends) tetani of single fibres isolated from the anterior tibialis muscle of Rana temporaria (temperature 1-3 degrees C; sarcomere ... -
Choosing Not to Take Phosphate Binders : The Role of Dialysis Patients' Medication Beliefs
Wileman, Vari; Chilcot, Joseph; Norton, Sam; Hughes, Lyndsay; Wellsted, D.; Farrington, Ken (2011)Objective: Patients with end-stage renal disease (ESRD) receiving haemodialysis are at risk of cardiovascular disease and bone disorders related to high levels of serum phosphate (PO(4)). Phosphate binders are an important ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (MDPI Multidisciplinary Digital Publishing Institute, 2022-05-01)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role ... -
Co-ordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats
Sack, Michael N.; Harrington, Louise; Jonassen, Anna K.; Mjos, O.D.; Yellon, Derek M. (2000-02)Fuel substrate utilization is highly regulated during cardiac development and with the onset of cardiac hypertrophy. Glucose and lactate are the predominant fuel substrates utilized during cardiac development. Postnatally, ... -
Communication as care at end of life : An emerging issue from an exploratory action research study of renal end-of-life care for ethnic minorities in the UK
Wilkinson, Emma K.; Randhawa, Gurch; Brown, Edwina Anne; Da Silva Gane, Maria; Stoves, John; Warwick, Graham L.; Akhtar, Tahira; Magee, Regina; Sharman, Sue; Farrington, Ken (2014-09)South Asian people have a higher risk of developing kidney disease, are disproportionately represented in the patient population requiring renal replacement therapy and wait longer to receive a kidney transplant, compared ... -
Contraction with shortening during stimulation or during relaxation : how do the energetic costs compare?
Lou, Fang; Curtin, N.A.; Woledge, R.C. (1998-10)White muscle fibres from dogfish were used to compare the energetic costs of shortening by fully active muscle and by relaxing muscle. The muscle preparation was tetanized for 0.6 s and shortened either during stimulation ... -
Contribution of COX1 and COX2 to prostacyclin release by healthy mouse tissues
Kirkby, N.S.; Harrington, Louise; Lundberg, Martina; Hoefer, T.; Warner, Tim D.; Mitchell, Jane A. (2011-06) -
Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function
Bucci, M.; Vellecco, V.; Brancaleone, V.; Roviezzo, F.; Mattace Raso, G.; Ianaro, A.; Meli, R.; Cirino, G.; Harrington, L.; Lungarella, G.; De Palma, R. (2013)Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR and TLR4 in ... -
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Kirkby, N.S.; Lundberg, M.H.; Harrington, L.S.; Leadbeater, P.D.M.; Potter, C.M.F.; Al-Yamani, M.; Adeyemi, O.; Mitchell, J.A.; Warner, T.D.; Milne, G.L. (2012-10-23)Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production ... -
Depression of tetanic force induced by loaded shortening of frog muscle fibres
Edman, K.A.P; Caputo, C.; Lou, Fang (1993-07)1. Single fibres isolated from the anterior tibialis muscle of Rana temporaria were allowed to shorten against a high load during a 2.5-4.0 s fused tetanus (1-3 degrees C) and the maximum force produced at the short length ... -
Dexamethasone selectivity inhibits induction of nitric oxide synthase, but not induction of L-arginine transport, in activated murine macrophage J774 cells
Bogle, R.G.; Baydoun, A. R.; Pearson, J.D.; Mann, G.E. (1994) -
Disease-specific predictive formulas for energy expenditure in the dialysis population
Vilar, Enric; Machado, Ashwini; Garrett, Andrew; Kozarski, Robert; Wellsted, D.; Farrington, Ken (2014-04-28)OBJECTIVE: Metabolic rate is poorly understood in advanced kidney disease because direct measurement is expensive and time-consuming. Predictive equations for resting energy expenditure (REE) are needed based on simple ... -
Distinct Depression Symptom Trajectories over the First Year of Dialysis : Associations with Illness Perceptions
Chilcot, Joseph; Norton, Sam; Wellsted, D.; Davenport, Andrew; Firth, John; Farrington, Ken (2013-02)BACKGROUND: Depression in the dialysis population is common, but trajectories of depression symptoms are unknown. PURPOSE: This study aims to (1) examine whether different patterns of depression symptoms exist over the ... -
Distinguishing Metabolic Heat from Condensation Heat during Muscle Recovery
Lou, Fang; Curtin, N.A.; Woledge, R.C. (1998)When a thermopile is used to measure the heat production of isolated muscle, the muscle is surrounded by gas saturated with water vapour, initially in equilibrium with the muscle. After contraction, the osmolarity of the ...